Abstract:
:Here we evaluate Bhattacharya et al.'s (2018) recent paper "Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia" published in Genome Research. In this short report, we examine the hypothesis that the so-called "Atacama skeleton" has skeletal abnormalities indicative of dysplasia, critique the validity of the interpretations of disease based on genomic analyses, and comment on the ethics of research on this partially mummified human foetus. The current paper acts as a case study of the importance of using an anthropological approach for aDNA research on human remains. A critical evaluation of the ethically controversial paper by Bhattacharya et al. highlights how an understanding of skeletal biological processes, including normal and abnormal growth and development, taphonomic processes, environmental context, and close attention to ethical issues of dealing with human remains, is vital to scientific interpretations. To this end, close collaboration with palaeopathologists and local archaeologists through appropriate peer-reviewed journals will add to the rigour of scientific interpretation and circumvent misinterpretation.
journal_name
Int J Paleopatholjournal_title
International journal of paleopathologyauthors
Halcrow SE,Killgrove K,Robbins Schug G,Knapp M,Huffer D,Arriaza B,Jungers W,Gunter Jdoi
10.1016/j.ijpp.2018.06.007subject
Has Abstractpub_date
2018-09-01 00:00:00pages
97-100eissn
1879-9817issn
1879-9825pii
S1879-9817(18)30054-8journal_volume
22pub_type
评论,杂志文章abstract:OBJECTIVE:This paper reviews paleo- and archaeoparasitology publications to date, from Iran. The primary focus is the importance of differential diagnosis and the crucial role of interdisciplinary collaborations among parasitologists and other specialists. METHODS:All relevant articles and theses published in Iran thr...
journal_title:International journal of paleopathology
pub_type: 杂志文章,评审
doi:10.1016/j.ijpp.2020.11.005
更新日期:2020-12-19 00:00:00
abstract::Over recent decades histology has increasingly been used as a diagnostic tool in human dry bone palaeopathology. Still, the use of histology in human dry bone is associated with various problems, including a lack of pathognomonic histomorphology and a need for more experimental data. Consequently, the value of histolo...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.03.004
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Paleopathological evidence of cancer from past populations is rare, especially outside of Europe and North Africa. This study expands upon the current temporal and spatial distribution of cancer by presenting a probable case of multiple myeloma from Bronze Age China. MATERIAL:The human skeletal remains of an...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.10.003
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:This case study describes a perimortem hip fracture in a documented individual from the Robert J. Terry Skeletal Collection. The purpose of this paper is to comprehend how co-occurring conditions contributed to fracture risk and to understand the effect of the injury on this individual. MATERIALS AND METHODS...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.03.004
更新日期:2020-09-01 00:00:00
abstract::This paper discusses the differential diagnosis of an unusual calcified mass found in the pelvic cavity of 45+-year-old female excavated from 15th-18th century Lisbon (Portugal). The mass is relatively large, irregularly shaped, and exhibits a concave base with malformed teeth embedded within its inner surface. Consid...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.05.001
更新日期:2017-09-01 00:00:00
abstract::Investigating injury recidivism and individuals with multiple injuries is an area of growing interest in bioarchaeology. Differentiating between whether an individual sustained multiple injuries, represented by antemortem healed fractures, in one incident or in multiple incidents over the life course, is a major chall...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.08.003
更新日期:2019-03-01 00:00:00
abstract::This report describes two adjacent, longitudinally-fused anterior cervical vertebrae from a basal archosauromorph. The specimen was collected from the Denwa Formation, Satpura Gondwana Basin, India. The differential diagnosis of the fusion includes genetic or environmentally-mediated congenital malformations, nonspeci...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.10.010
更新日期:2018-03-01 00:00:00
abstract::Survival of an adult male (M9) with juvenile-onset quadriplegia in Neolithic Vietnam indicates provision of continuous care from his community, and adds to the growing literature documenting survival of disabled individuals in prehistory. Although the role of care-giving in achieving survival is occasionally acknowled...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.02.003
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The aim of this paper was to analyse the dental remains of an adult male with three impacted canines from the Roman period cemetery in Osijek, Croatia. MATERIALS:The dental remains of an adult male aged 35-45 years at the time of death were analysed. METHODS:Macroscopic analysis of dental remains was accomp...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.10.004
更新日期:2019-03-01 00:00:00
abstract::The analysis of 16th century graves from Zagreb, Croatia, revealed a case of frontal sinus osteoma in a middle-aged female. This lesion was discovered during visual examination, due to postmortem breakage of the frontal bone. The significance of this finding is based on the fact that frontal sinus osteomas are very ra...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.02.002
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:The aim of this paper is to provide new insights into growth patterns and health of Mousterian hunter-gatherers dated to ca. 90-100 kyrs B.P. from the Qafzeh site. MATERIALS:An almost complete skeleton, including the mandible from the Qafzeh site (Qafzeh 9). METHODS:Micro-CT and medical imaging techniques a...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2019.06.002
更新日期:2019-09-01 00:00:00
abstract::Clinical reports for Eleonora of Toledo (1522-1562), the wife of Cosimo I de' Medici, imply that during her 28th year she developed pulmonary tuberculosis, which was complicated by an attack of pernicious malaria, killing her at age 40. Eleonora's autopsy indicated that she had severe lung lesions consistent with chro...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.11.002
更新日期:2012-12-01 00:00:00
abstract::During recent years, the presence of linear ridges or islands of bone ('buttresses') on the anterior aspect of sheep metatarsals has assumed increased visibility in zooarchaeological studies. Although a number of causes have been suggested, the etiology and pathogenesis of this condition has remained unresolved. In th...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.02.006
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:This study was undertaken to identify pathological conditions within the population living at Atalla (1000-500 BCE), an important early village site and ritual center located in Huancavelica, Peru. MATERIALS:Articulated burials (N = 3) and commingled human remains excavated during the 2015 and 2016 field sea...
journal_title:International journal of paleopathology
pub_type:
doi:10.1016/j.ijpp.2019.11.004
更新日期:2020-03-01 00:00:00
abstract::A description of the late mediaeval skeleton (AD 1150-1539) of a young child with probable signs of tuberculosis is presented. This individual was recovered along with one hundred and ninety skeletons from the cemetery of the priory of SS Peter and Paul, Taunton, Somerset. Aged between three and five years old at deat...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.04.001
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To present for the first time in the north-western Spanish osteological record prevalence data on Stafne's bone defect, to compare the results with those reported by other studies, and to increase the dataset for future inter-population comparisons. MATERIAL:In all, 143 complete adult mandibles recovered fro...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.08.001
更新日期:2020-12-01 00:00:00
abstract::Human and animal ectoparasites are often recovered from archaeological contexts being examined for preserved insect remains. Records of human lice, fleas and bedbugs are used to reconstruct past sanitary conditions and practices, as well as their geographic distribution and that of the pathogens for which they may be ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.07.004
更新日期:2013-09-01 00:00:00
abstract::Only relatively few cases of dental abnormalities in wild ruminants have thus far been described in the paleopathological literature. This study reports a case of cementoblastoma, a benign odontogenic tumor of ectomesenchymal origin, in a red deer (Cervus elaphus) from the Late Pleistocene of Rochedane, a prehistoric ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2014.09.004
更新日期:2015-03-01 00:00:00
abstract::A case of potentially dedifferentiated parosteal osteosarcoma was found in the proximal humerus of an adult female buried in the late Anglo-Saxon cemetery of Cherry Hinton, Cambridgeshire, UK. Key features include a large, dense, lobulated mass attached to the medial metaphysis of the proximal humerus by a broad-based...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2016.12.001
更新日期:2018-06-01 00:00:00
abstract::A Neolithic Belgian mandible from Bois Madame rockshelter in Arbre presents an asymmetrical morphology resulting from a secondary, or false, articulation of the right mandibular condyle. The pathological articulation produced enlarged masseter, medial pterygoid and mylohyoid musculature on the right side as well as a ...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2016.12.003
更新日期:2017-03-01 00:00:00
abstract::Osteochondritis Dissecans (OD) is a pathological condition of the subchondral bone and surrounding cartilage of synovial joints, associated with strenuous activity and/or trauma. Reports of OD in archaeological skeletal remains are few and the majority demonstrate low OD prevalence (<1%). A predominantly 19th century ...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.09.005
更新日期:2017-12-01 00:00:00
abstract::During the 2011 excavation of the site of St. Michael's Litten, in Chichester, England, a female skeleton, dating to the post-Medieval period (1550-1850), with a large, unidentified pelvic mass was uncovered. The mass measured 16.4H×19.0W×24.3L and was 66cm in its greatest circumference; it weighed 3.32kg. The skeleto...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2015.05.003
更新日期:2015-09-01 00:00:00
abstract::The soft tissue preservation system (STPS) is emerging as a method of expressing the degree of soft tissue present on an ancient human body (mummy). In this system the intact body is divided into five anatomic segments (head, thorax, pelvis, arms and legs). Each of these segments is assigned a maximal potential number...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.10.003
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:This study examines the evidence of three skeletal markers of childhood health that leave permanent observable changes in the adult skeleton during two climate events, the Medieval Warm Period (MWP) and the Little Ice Age (LIA) that occurred in the medieval period (1050-1536 CE). MATERIAL:A total of 241 adul...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.ijpp.2019.09.003
更新日期:2019-12-01 00:00:00
abstract::The identification of violence and trauma in an archaeological context requires a nuanced and detailed analysis of material culture and human remains. This paper focuses on sharp-force trauma data from individual skeletal elements for the Ancestral Pueblo site Peñasco Blanco (n=1301) and the epiclassic site La Quemada...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.09.015
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate lesions on a cranium from the Iberian Peninsula and assess its medico-historical and paleopathological significance. MATERIALS:The skeletal remains of a juvenile individual found in a Medieval Islamic grave (10th -16th century) in Eastern Spain. METHODS:Macroscopic examination of the left and ri...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.10.009
更新日期:2020-11-21 00:00:00
abstract:OBJECTIVE AND MATERIALS:This research evaluates the presence and chronology of tuberculosis (TB) in the northeastern highlands of Peru (CE 800-1535) through the analysis of osseous lesions from Pre-Contact Kuelap, Chachapoyas. METHODS:We examined macroscopic lesion morphology and distribution from the skeletal series ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.04.002
更新日期:2020-09-01 00:00:00
abstract::Alcohol Related Birth Defects (ARBD) are yet undocumented among past communities, although alcohol is the leading cause of non-heritable birth defects in the US today. We evaluate potential ARBD at Newton Plantation, Barbados (ca. 1660-1820), where earlier studies suggest frequent, community-wide consumption of lead-t...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.08.005
更新日期:2013-12-01 00:00:00
abstract::A skeleton excavated from the Blossom Mound (CA-SJO-68), a Late Holocene (4350-2980 BP) site located in the northern San Joaquin Valley of California, exhibits evidence of unusual craniofacial and postcranial features consistent with endocrine disease. Burial 37, an adult male approximately 30-40 years of age, shows p...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.11.003
更新日期:2014-03-01 00:00:00
abstract::This is the first systematic large-scale palaeopathological study of adult vitamin D deficiency osteomalacia. One thousand one hundred and eighty-one skeletons from multiple urban contexts in post-mediaeval England (c. AD 1700-1855) were analysed. Twelve adults with evidence of osteomalacia were identified. When added...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2014.06.004
更新日期:2014-12-01 00:00:00