Abstract:
OBJECTIVE:Paleopathological evidence of cancer from past populations is rare, especially outside of Europe and North Africa. This study expands upon the current temporal and spatial distribution of cancer by presenting a probable case of multiple myeloma from Bronze Age China. MATERIAL:The human skeletal remains of an adult male from the Qijia culture horizon (1750-1400 BCE) of the Bronze Age cemetery of Mogou (), located in Gansu Province, Northwest China. METHODS:The human skeletal remains were assessed macroscopically and radiographically using plain x-rays. RESULTS:Multiple ovoid-shaped osteolytic lesions with sharply demarcated margins were observed. The axial skeletal had the greatest involvement, specifically the vertebrae, ribs, and sternum. Radiographic imaging revealed more extensive destruction of cancellous than cortical bone, indicating that the marrow was the focal point of the disease. CONCLUSION:Based on the nature, distribution, and radiographic appearance of the lesions, the most likely diagnosis is multiple myeloma. SIGNIFICANCE:This is one of the only cases of cancer identified in archaeological human skeletal remains from East Asia and is the first published case of a hematopoietic malignancy from mainland China. The analysis and publication of examples of neoplasia from areas that expand upon the current known temporal and spatial distribution is necessary in order to better reconstruct the history and evolution of cancer. LIMITATIONS:Poor skeletal preservation prevented the full extent of osteolytic lesions to be observed. SUGGESTIONS FOR FUTURE RESEARCH:By placing case studies such as this into a temporal and spatial framework, it is possible for future research to begin to interrogate possible underlying causes of cancer in ancient populations within the context of changing environmental conditions and subsistence strategies.
journal_name
Int J Paleopatholjournal_title
International journal of paleopathologyauthors
Dittmar JM,Berger ES,Mao R,Wang H,Yeh HYdoi
10.1016/j.ijpp.2020.10.003subject
Has Abstractpub_date
2020-12-01 00:00:00pages
64-70eissn
1879-9817issn
1879-9825pii
S1879-9817(20)30049-8journal_volume
31pub_type
杂志文章abstract::This paper discusses the differential diagnosis of an unusual calcified mass found in the pelvic cavity of 45+-year-old female excavated from 15th-18th century Lisbon (Portugal). The mass is relatively large, irregularly shaped, and exhibits a concave base with malformed teeth embedded within its inner surface. Consid...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.05.001
更新日期:2017-09-01 00:00:00
abstract::This article serves as an introduction to the International Journal of Paleopathology's special issue, Paleo-oncology: Taking Stock and Moving Forward. Reflecting the goals of the special issue, this paper has been designed to provide an overview of the current state of paleo-oncology, to introduce new and innovative ...
journal_title:International journal of paleopathology
pub_type: 历史文章
doi:10.1016/j.ijpp.2018.02.001
更新日期:2018-06-01 00:00:00
abstract::A description of the late mediaeval skeleton (AD 1150-1539) of a young child with probable signs of tuberculosis is presented. This individual was recovered along with one hundred and ninety skeletons from the cemetery of the priory of SS Peter and Paul, Taunton, Somerset. Aged between three and five years old at deat...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.04.001
更新日期:2012-03-01 00:00:00
abstract::Saranda Kolones (Forty Columns) at Paphos in Cyprus was a mediaeval concentric castle built after King Richard I of England captured the island in 1191AD, during the Third Crusade. The aim of this research is to determine whether the garrison of the castle was infected by intestinal parasitic helminths (endoparasites)...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.04.003
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:Skeletons sampled for ancient human DNA analysis are sometimes complete enough to provide information about the lives of the people they represent. We focus on three Later Stone Age skeletons, ca. 2000 B.P., from coastal KwaZulu-Natal, South Africa, whose ancient genomes have been sequenced (Schlebusch et al., ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2018.10.008
更新日期:2019-03-01 00:00:00
abstract::Archaeozoology provides bones, which quite regularly present traces of fractures. These fractures are more or less at an advanced level of healing and bear witness to traumas or pathologies. These cases of palaeopathology are not always the subject of publications, which further restricts our knowledge about them. Thi...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.07.004
更新日期:2018-09-01 00:00:00
abstract::Survival of an adult male (M9) with juvenile-onset quadriplegia in Neolithic Vietnam indicates provision of continuous care from his community, and adds to the growing literature documenting survival of disabled individuals in prehistory. Although the role of care-giving in achieving survival is occasionally acknowled...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.02.003
更新日期:2011-03-01 00:00:00
abstract::This is the first systematic large-scale palaeopathological study of adult vitamin D deficiency osteomalacia. One thousand one hundred and eighty-one skeletons from multiple urban contexts in post-mediaeval England (c. AD 1700-1855) were analysed. Twelve adults with evidence of osteomalacia were identified. When added...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2014.06.004
更新日期:2014-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.10.004
更新日期:2019-03-01 00:00:00
abstract::The Neolithic colonisation of the Pacific islands was one of the most challenging migration events in human history. The regions east of the Solomon Islands were colonised relatively recently by a people known as the Lapita. The Lapita brought with them a 'transported landscape' of domesticated plants and animals that...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2014.03.001
更新日期:2014-06-01 00:00:00
abstract::Analytically sophisticated paleoepidemiology is a relatively new development in the characterization of past life experiences. It is based on sound paleopathological observations, accurate age-at-death estimates, an explicit engagement with the nature of mortality samples, and analytical procedures that owe much to ep...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2017.03.007
更新日期:2017-06-01 00:00:00
abstract::The objective of the present study is to test our general knowledge of sex-specific survival differences in past northern France societies by implementing the tooth cementum annulations method of age estimation (i.e., cementochronology) to bio-archaeological series. 1255 individual estimated ages at death covering a m...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2015.05.001
更新日期:2016-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2015.11.004
更新日期:2016-03-01 00:00:00
abstract::Dental root fractures are rarely documented in past human populations, but when they are observed, diagnosing ante-mortem events as causal factors can be difficult due to postmortem alteration. Can high resolution X-ray computed tomography (CT) improve our ability to diagnose if a dental fracture was caused ante- or p...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.10.004
更新日期:2018-09-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.10.010
更新日期:2018-03-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2016.01.004
更新日期:2016-06-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.08.001
更新日期:2020-12-01 00:00:00
abstract::The custom of burying deceased members of the elite beneath church floors was common in 17th-18th-century Finland. This practice is responsible for the mummification of the remains of an early 17th-century vicar of Kemi parish, Nikolaus Rungius. Computed tomography performed on his remains revealed a possible tubercul...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2016.05.009
更新日期:2016-09-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2019.07.003
更新日期:2019-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.09.015
更新日期:2012-01-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.04.002
更新日期:2020-09-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2016.12.003
更新日期:2017-03-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.08.003
更新日期:2019-03-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章,评审
doi:10.1016/j.ijpp.2020.11.005
更新日期:2020-12-19 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2015.05.003
更新日期:2015-09-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.10.003
更新日期:2011-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.10.011
更新日期:2018-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.ijpp.2019.09.003
更新日期:2019-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.11.002
更新日期:2012-12-01 00:00:00
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journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2016.12.001
更新日期:2018-06-01 00:00:00