Abstract：
BACKGROUND:Giant cell tumors (GCTs) are benign tumors with a predilection for the epimetaphyseal region of the long bones. GCTs involving the skull base are rare, and only a few available cases have been reported. Surgical gross total resection is the recommended method of treatment for GCTs. In the case of skull base tumors, it is very difficult to achieve such a result by direct surgical resection alone without any morbidities. Denosumab is a fully humanized monoclonal anti-receptor activator of nuclear factor-κB ligand antibody that has been recently approved by the Food and Drug Administration for the treatment of GCTs that are surgically unresectable, metastatic, and have a high risk of progression and recurrence. Denosumab has been used in many cases involving the long bones. However, in cases of skull base GCTs, only a limited number of cases have been reported. In addition, in such cases, it was used as postoperative chemotherapy owing to subtotal resection. CASE DESCRIPTION:For the present patient, we adopted a unique approach in which denosumab was administered as neoadjuvant chemotherapy to reduce the size of the tumor to a resectable level. Subsequently, surgical resection was performed with good functional and histopathological outcomes. CONCLUSIONS:Our findings emphasize the use of denosumab as a neoadjuvant treatment routinely for all cases of skull base GCTs to achieve safe and complete excision of the tumor.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Sekar A,Rudrappa S,Gopal S,Ghosal N,Gupta V,Ts Ldoi
10.1016/j.wneu.2018.07.207subject
Has Abstractpub_date
2018-11-01 00:00:00pages
97-102eissn
1878-8750issn
1878-8769pii
S1878-8750(18)31687-5journal_volume
119pub_type
杂志文章abstract：BACKGROUND:Osteosarcoma is the second most common primary tumor of the skeletal system and the most common primary bone tumor. Usually occurring at the metaphysis of long bones, osteosarcomas are highly aggressive lesions that comprise osteoid-producing spindle cells. Craniofacial osteosarcomas comprise <8% and are bel...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
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abstract：:The authors discuss the implications of the COVID-19 pandemic on the use of telehealth in the United States. ...
journal_title：World neurosurgery
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journal_title：World neurosurgery
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doi：10.1016/j.wneu.2016.01.023
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abstract：BACKGROUND:Primary central nervous system neuroblastoma (PCNSN) is a rare disease, and its incidence, treatment modalities, and survival remain poorly understood. METHODS:The SEER (Surveillance Epidemiology and End Results) database was used to identify patients diagnosed with PCNSN from 1973 to 2013. The incidence an...
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doi：10.1016/j.wneu.2018.03.138
更新日期：2018-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.075
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:De novo aneurysm formation has been reported as a rare complication of superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery. CASE DESCRIPTION:The first patient with intracerebral hemorrhage had a ruptured de novo aneurysm arising from the recipient MCA at 6 years after undergoing...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2016.05.075
更新日期：2016-08-01 00:00:00
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journal_title：World neurosurgery
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doi：10.1016/j.wneu.2020.05.180
更新日期：2020-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.09.237
更新日期：2019-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.12.109
更新日期：2018-03-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.06.044
更新日期：2020-09-01 00:00:00
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更新日期：2015-05-01 00:00:00
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doi：10.1016/j.wneu.2017.09.079
更新日期：2017-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.077
更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.029
更新日期：2018-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.01.176
更新日期：2019-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.024
更新日期：2016-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.143
更新日期：2017-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.072
更新日期：2018-04-01 00:00:00
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更新日期：2012-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.11.017
更新日期：2018-02-01 00:00:00
