Magnetic Resonance Imaging-Apparent Diffusion Coefficient Assessment of Vestibular Schwannomas: Systematic Approach, Methodology, and Pitfalls.

Abstract:

OBJECTIVE:To investigate the validity of various approaches to extract quantitative measurements of diffusion imaging (i.e., apparent diffusion coefficient [ADC]) to investigate tumors of the central nervous system. In current studies, the region of interest (ROI) for the quantitative measurements are placed arbitrarily according to morphology. Our aim is to investigate how placement patterns influence the ADC estimation in intracranial tumors. METHODS:Twenty consecutive patients affected by vestibular schwannoma were studied using diffusion imaging. ADC values were obtained using different ROI placement methods: segmentation ADC values of the entire volume (vADC), random ADC values were obtained in 10 different ROI points, and a single ROI in the ADC of the internal auditory canal portion of the tumor. RESULTS:ADC of the internal auditory canal portion of the tumor and vADC differed significantly (P < 0.01). vADC was different between cystic and microcystic schwannomas (P = 0.009) and between cystic and solid schwannomas (P = 0.006). CONCLUSIONS:The positioning of ROI in these measurements is pivotal. Although "whole tumor volume" measurements represent the largest amount of information, multiple seed points can be used as well. However, there must be multiple seeds and their placement must be reported. ADC can be used as a versatile tool for tumor assessment but must be used judiciously and structured to yield comparable results.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Giordano M,Samii A,Samii M,Nabavi A

doi

10.1016/j.wneu.2019.01.176

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

e820-e823

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(19)30287-6

journal_volume

125

pub_type

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