当前位置： SCI文献检索 > SURGERY期刊下所有文献 > Over expression of DNA damage and cell cycle dependent proteins are associated with poor survival in patients with adrenocortical carcinoma.

Over expression of DNA damage and cell cycle dependent proteins are associated with poor survival in patients with adrenocortical carcinoma.

Abstract：

BACKGROUND:Adrenocortical carcinoma is a rare and aggressive malignancy with poor survival. With limited treatment options and high risk of relapse, identifying improved targets and therapies for adrenocortical carcinoma is important. We hypothesized that analysis of the database of The Cancer Genome Atlas could identify important novel biomarkers for improved therapeutic targeting of adrenocortical carcinoma. METHODS:We utilized the University of Alabama interactive web resource to identify novel biomarkers observed in 79 adrenocortical carcinoma patients. Identified biomarkers were then examined for prognostic correlations using the cBioPortal and analyzed for statistical significance using STATA 13.0. RESULTS:The Cancer Genome Atlas data mining in the University of Alabama interactive web resource for pathways associated with poor survival of patients with adrenocortical carcinoma revealed significant upregulation of genes involved in DNA damage and regulation of cell-cycle pathways, such as AURKA, AURKB, CDK1, CDK4, CDK6, PLK1, CHEK1, CHEK2, CDC7, BUB3, and MCM3 (P < .001-.05). On outcome correlation, greater expression levels of all the genes except CDK4 were associated with worse survival compared with medium or low levels of gene expression (P < .001 all) irrespective of age orsex. Consistent with our University of Alabama interactive web resource findings, data mining in the cBioPortal also revealed upregulation of genes regulating DNA-damage and cell cycle-related genes in 82% of patients (z score = 1.5). CONCLUSION:Large data mining from the The Cancer Genome Atlas and cBioPortal databases identified overexpression of genes involved in DNA damage and those regulating pathways of the cell cycle, which correlated with poorer overall survival in adrenocortical carcinoma patients.

journal_name

Surgery

journal_title

Surgery

authors

Subramanian C,Cohen MS

doi

10.1016/j.surg.2018.04.080

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

202-210

issue

1

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(18)30580-4

journal_volume

165

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Laparoscopic splenectomy: outcomes and lessons learned from over 200 cases.

    abstract：BACKGROUND:In this study of laparoscopic splenectomy (LS), we evaluate prospectively gathered perioperative patient data and review lessons learned in the evolution of this procedure. METHODS:At 2 university medical centers between November 1993 and March 2000, there were 203 patients (122 female patients and 81 male ...

    journal_title：Surgery

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1067/msy.2000.109065

    authors： Park AE,Birgisson G,Mastrangelo MJ,Marcaccio MJ,Witzke DB

    更新日期：2000-10-01 00:00:00

  • Intrahepatic biliary cystadenoma: role of cyst fluid analysis and surgical management in the laparoscopic era.

    abstract：BACKGROUND:Recent interest in cyst fluid analysis (CFA) for carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA), and the introduction of laparoscopic surgery (LS) in the management of hepatic cysts have resulted in sporadic reports of elevated CA 19-9 and CEA levels in intrahepatic biliary cystadenom...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2004.06.031

    authors： Koffron A,Rao S,Ferrario M,Abecassis M

    更新日期：2004-10-01 00:00:00

  • Depression of myocardial ATPase activity by plasma obtained during positive end-expiratory pressure.

    abstract：:Dogs treated with 15 cm H2O positive end-expiratory pressure (PEEP) invariably show a decrease in cardiac output (CO). Plasma that is obtained from PEEP-treated dogs and applied to an isometrically contracting rat papillary muscle results in a significant depression of the peak developed tension. The present study eva...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Utsunomiya T,Krausz MM,Dunham B,Shepro D,Hechtman HB

    更新日期：1982-03-01 00:00:00

  • Consequences of preoperative cholangitis and its treatment on the outcome of operation for choledocholithiasis.

    abstract：:During a 30-month period 73 patients underwent operation for choledocholithiasis. Thirty-three of these patients (45%) had cholangitis preoperatively. When compared to patients with common duct stones who had no preoperative cholangitis, patients with cholangitis were older (P less than 0.001), more likely to present ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Pitt HA,Postier RG,Cameron JL

    更新日期：1983-09-01 00:00:00

  • Compliance and biodegradation of vascular grafts stimulate the regeneration of elastic laminae in neoarterial tissue: an experimental study in rats.

    abstract：:Microporous vascular grafts that are compliant and biodegradable can function as scaffolds for the regeneration of the arterial wall in small-caliber arteries. The purpose of this study was to determine the specific influence of both compliance and biodegradation of microporous vascular grafts on this regeneration, es...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： van der Lei B,Wildevuur CR,Nieuwenhuis P

    更新日期：1986-01-01 00:00:00

  • New insights into the pathophysiology of postoperative hemorrhage in thyroid surgery: An experimental study in a porcine model.

    abstract：BACKGROUND:Postoperative cervical hemorrhage is a rare but life-threatening complication that can cause severe morbidity. Different mechanisms leading to asphyxia have been described based only on clinical observation. METHODS:We performed a series of in vivo animal studies simulating post-thyroidectomy hemorrhage and...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2018.05.022

    authors： Schopf S,von Ahnen T,von Ahnen M,Schardey HM,Wirth U

    更新日期：2018-09-01 00:00:00

  • Continued experience with intraoperative angioscopy for monitoring infrainguinal bypass grafting.

    abstract：:Intraoperative angioscopy provides direct, in vivo, three-dimensional visualization of the interior of the blood vessels and grafts. We have shown previously that with the application of the basic principles of irrigation and with a dedicated irrigation pump that routine intraoperative angioscopy can be performed with...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Miller A,Stonebridge PA,Jepsen SJ,Tsoukas A,Gibbons GW,Pomposelli FB Jr,Freeman DV,Campbell DR,LoGerfo FW

    更新日期：1991-03-01 00:00:00

  • Quantitative photoplethysmography in chronic venous insufficiency: a new method of noninvasive estimation of ambulatory venous pressure.

    abstract：:We estimated ambulatory venous pressure (AVP) noninvasively with a new technique of quantitative photoplethysmography (PPG). Postural changes of hydrostatic pressure permitted in vivo calibration of the PPG. We recorded quantitative PPG and AVP in 14 normal subjects and 14 patients with postthrombotic chronic venous i...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Norris CS,Beyrau A,Barnes RW

    更新日期：1983-11-01 00:00:00

  • Less is more: cost-effectiveness analysis of surveillance strategies for small, nonfunctional, radiographically benign adrenal incidentalomas.

    abstract：BACKGROUND:Guidelines for management of small adrenal incidentalomas are mutually inconsistent. No cost-effectiveness analysis has been performed to evaluate rigorously the relative merits of these strategies. METHODS:We constructed a decision-analytic model to evaluate surveillance strategies for <4cm, nonfunctional,...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2017.07.030

    authors： Chomsky-Higgins K,Seib C,Rochefort H,Gosnell J,Shen WT,Kahn JG,Duh QY,Suh I

    更新日期：2018-01-01 00:00:00

  • The prognostic significance of the positive circumferential resection margin in pathologic T3 squamous cell carcinoma of the esophagus with or without neoadjuvant chemotherapy.

    abstract：BACKGROUND:To improve the therapeutic strategy for esophageal squamous cell carcinoma (ESCC), combined neoadjuvant chemotherapy (NAC) followed by operative surgical resection has been applied recently to patients at clinical stages II/III. Our study aimed to elucidate the impact of the circumferential resection margin ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2015.06.044

    authors： Okada N,Fujii S,Fujita T,Kanamori J,Kojima T,Hayashi R,Daiko H

    更新日期：2016-02-01 00:00:00

  • Reoperative parathyroid surgery for persistent hyperparathyroidism.

    abstract：:In a 2-year period 30 patients with persistent hyperparathyroidism following 59 prior unsuccessful procedures underwent reoperation. Preoperative arteriography was useful in planning the surgical approach in 56%, and retrospectively was correct in 63%. Selective venous catheterization gave localizing information in 83...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Brennan MF,Doppman JL,Marx SJ,Spiegel AM,Brown EM,Aurbach GD

    更新日期：1978-06-01 00:00:00

  • Role of myofibroblasts in pseudointima formation.

    abstract：:Twenty Dacron grafts (10 crimped and 10 noncrimped) were studied with light microscopy, scanning electron microscopy, and transmission electron microscopy (TEM) 1 to 10 months after insertion into the canine thoracoabdominal aorta. Fibroblast-derived pseudointima maintained a smooth luminal lining that approximated th...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Sottiurai VS,Batson RC

    更新日期：1983-11-01 00:00:00

  • Highly selective vagotomy in the treatment of duodenal ulcer in a teaching hospital. A one-to-three year follow-up relating results to the number of operating surgeons, their surgical experience, and training conditions.

    abstract：:In the present series, highly selective vagotomy (HSV) was used in the treatment of duodenal ulcer and the patients were followed up 1 to 3 years after operation. Three months after operation, 57% of the patients had positive insulin tests (early and late positive). Ulcer recurrence rate was approximately 6.5%, wherea...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Solhaug JH,Bjerkeset T,Halvorsen JF

    更新日期：1977-08-01 00:00:00

  • Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome.

    abstract：BACKGROUND:The development of liver failure significantly influences prognosis during the course of major septic complications. Although the underlying cause for septic liver failure is still unclear, research using animal models has demonstrated that an increased nitric oxide (NO) synthesis compromises detoxification ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2006.08.011

    authors： Novotny AR,Emmanuel K,Maier S,Westerholt A,Weighardt H,Stadler J,Bartels H,Schwaiger M,Siewert JR,Holzmann B,Heidecke CD

    更新日期：2007-03-01 00:00:00

  • Immunomodulators in the treatment of peritonitis in burned and malnourished animals.

    abstract：:Deficiencies in the immune system that lead to increased morbidity and mortality from infectious complications have been well documented in patients suffering from trauma, malnutrition, sepsis, and thermal injuries. We investigated the potential benefit of immune stimulation for preventing infection in such conditions...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Waymack JP,Miskell P,Gonce SJ,Alexander JW

    更新日期：1984-08-01 00:00:00

  • Hypoglycemia after resection of pheochromocytoma.

    abstract：BACKGROUND:Hypoglycemia after resection of pheochromocytoma is a rare and poorly understood complication thought to be secondary to rebound hyperinsulinemia and increased peripheral glucose uptake. We examined the incidence of this complication and aimed to identify predisposing risk factors. METHODS:Patients who unde...

    journal_title：Surgery

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.surg.2014.08.020

    authors： Chen Y,Hodin RA,Pandolfi C,Ruan DT,McKenzie TJ

    更新日期：2014-12-01 00:00:00

  • Treatment of toxic solitary thyroid nodules: surgery versus radioactive iodine.

    abstract：BACKGROUND:Because of controversy about the correct treatment of toxic solitary thyroid nodules, we reviewed our experience. METHODS:We retrospectively studied 32 patients (24 women and 8 men) with solitary toxic thyroid nodules who were treated at our institution (1970 to 1985). RESULTS:Median values were as follows...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： O'Brien T,Gharib H,Suman VJ,van Heerden JA

    更新日期：1992-12-01 00:00:00

  • Necrotizing enterocolitis totalis: High mortality in the absence of an aggressive surgical approach.

    abstract：BACKGROUND:Necrotizing enterocolitis is the leading case of gastrointestinal-related morbidity in premature infants. Necrotizing enterocolitis totalis is an aggressive form of necrotizing enterocolitis, which has traditionally been managed with comfort care. Recent advances in management of short bowel syndrome have re...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2019.03.005

    authors： Dukleska K,Devin CL,Martin AE,Miller JM,Sullivan KM,Levy C,Prestowitz S,Flathers K,Vinocur CD,Berman L

    更新日期：2019-06-01 00:00:00

  • Hemoductal pancreatitis.

    abstract：:Gastrointestinal tract hemorrhage from rupture of the splenic artery into the pancreatic duct is unusual. This obscure cause of intermittent gastrointestinal tract bleeding should be suspected when the more common causes of bleeding have been ruled out. Duodenoscopy carried out during active hemorrhage may reveal bloo...

    journal_title：Surgery

    pub_type： 杂志文章,评审

    doi：

    authors： Camishion RC,Pello MJ,Spence RK,Alexander JB,Atabek UM,Kuroda K

    更新日期：1992-01-01 00:00:00

  • Indicators of prognosis after hepatic resection for colorectal secondaries.

    abstract：:From 1960 to 1988, 266 patients underwent resection of colorectal secondaries to the liver with curative intent. All patients were followed until April 1, 1990, or death, with a median follow-up time of 52 months. Nine patients with minimal macroscopic residual disease and 38 patients with all gross tumor removed but ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Scheele J,Stangl R,Altendorf-Hofmann A,Gall FP

    更新日期：1991-07-01 00:00:00

  • Effects of tumor removal and body weight loss on insulin resistance in patients with cancer.

    abstract：BACKGROUND:This study was conducted to evaluate the effects of tumor removal and body weight loss on insulin resistance. METHODS:Insulin sensitivity was examined in 12 patients with cancer and stable weight and five patients with cancer and weight loss before operation, six patients after complete tumor removal, and t...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Yoshikawa T,Noguchi Y,Matsumoto A

    更新日期：1994-07-01 00:00:00

  • Chronic steroid use as an independent risk factor for perioperative complications.

    abstract：BACKGROUND:Corticosteroid use continues to rise nationally. Studies have evaluated the impact of chronic steroid use on surgical outcomes in smaller populations. This study investigated the impact of chronic steroid use on perioperative surgical outcomes in a surgical cohort of more than 5 million surgical patients, us...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2018.12.016

    authors： Chouairi F,Torabi SJ,Mercier MR,Gabrick KS,Alperovich M

    更新日期：2019-05-01 00:00:00

  • Effect of pentoxifylline on hepatic ischemia and reperfusion injury.

    abstract：BACKGROUND:Although pentoxifylline has been shown to improve tissue oxygenation and restore hepatocellular function after hemorrhagic shock, its effect on hepatic ischemia and reperfusion injury has not been fully clarified. The purpose of this study was to determine whether pentoxifylline exerted beneficial effects on...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/s0039-6060(97)90106-9

    authors： Fabia R,Travis DL,Levy MF,Husberg BS,Goldstein RM,Klintmalm GB

    更新日期：1997-05-01 00:00:00

  • A comparative study of serum ultrafiltrable, ionized, and total calcium in the diagnosis of primary hyperparathyroidism in patients with intermittent or no elevation in total calcium.

    abstract：:Measurement of serum ionized calcium has been shown to be more sensitive a method of diagnosing primary hyperparathyroidism than total calcium in patients with subtle or intermittent elevations of total calcium. The measurement of ionized calcium, however, is technically difficult. The measurement of serum ultrafiltra...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Forster J,Monchik JM,Martin HF

    更新日期：1988-12-01 00:00:00

  • Predicting burn patient mortality with electronic medical records.

    abstract：BACKGROUND:Although there exists robust literature on mortality-associated factors in burn patients, it is not known how electronic medical records affect outcomes. Using burn injury as a surgical care model of information and communication, we hypothesized that functionality and interoperability of the electronic medi...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2018.07.010

    authors： Cheung M,Cobb AN,Kuo PC

    更新日期：2018-10-01 00:00:00

  • Older veterans undergoing inpatient surgery: What is the compliance with best practice guidelines?

    abstract：BACKGROUND:The United States population is aging, and the number of older adults requiring operative care is increasing at a rapid rate. In order to address this issue, the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society created best practice guidelines sur...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2020.08.033

    authors： Dworsky JQ,Shenoy R,Childers CP,Russell MM

    更新日期：2021-02-01 00:00:00

  • Females have fewer complications and lower mortality following trauma than similarly injured males: a risk adjusted analysis of adults in the National Trauma Data Bank.

    abstract：BACKGROUND:Studies of sexual dimorphism in trauma outcomes suggest that women have a survival advantage compared to equivalently injured men. It is unknown if this gender disparity is mediated by potentially life-threatening complications. OBJECTIVE:To determine (1) if there is a sex-based differences in the odds of d...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2009.05.006

    authors： Haider AH,Crompton JG,Oyetunji T,Stevens KA,Efron DT,Kieninger AN,Chang DC,Cornwell EE 3rd,Haut ER

    更新日期：2009-08-01 00:00:00

  • Learning sentinel node biopsy: results of a prospective randomized trial of two techniques.

    abstract：BACKGROUND:Evidence indicates that sentinel node (SN) biopsy can accurately predict axillary nodal status. Debate exists as to the optimal method of SN identification. METHODS:Patients with clinical T1 or T2 tumors and negative axillae were randomized to SN localization with blue dye (B) alone (n = 50) or blue dye plu...

    journal_title：Surgery

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Morrow M,Rademaker AW,Bethke KP,Talamonti MS,Dawes LG,Clauson J,Hansen N

    更新日期：1999-10-01 00:00:00

  • The surgical treatment of superficial thrombophlebitis.

    abstract：:Of 3,941 patients who underwent varicose vein surgery from 1968 through 1978, 163 had superficial thrombophlebitis, a common complication of varicose veins. Superficial thrombophlebitis was more frequently found in the older age groups. The incidence of occurrence (three women to one man) was identical to that of the ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Lofgren EP,Lofgren KA

    更新日期：1981-07-01 00:00:00

  • Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome.

    abstract：BACKGROUND:Glucagon-like peptide-2 induces small intestine mucosal epithelial cell proliferation and may have benefit for patients who suffer from short bowel syndrome. However, glucagon-like peptide-2 is inactivated rapidly in vivo by dipeptidyl peptidase IV. Therefore, we hypothesized that selectively inhibiting dipe...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2011.05.013

    authors： Okawada M,Holst JJ,Teitelbaum DH

    更新日期：2011-08-01 00:00:00