Abstract：
BACKGROUND:Invasive pituitary adenomas often recurred after postoperative radiotherapy and are difficult to treat. Temozolomide (TMZ) is an alkylating cytostaticum and has been reported to reduce pituitary tumor size and hormone hypersecretion, However, this is far from enough. Pituitary adenomas have relatively high expression of vascular endothelial growth factor. Therefore, antiangiogenic agent has been used in a small number of aggressive or malignant pituitary tumors after recurrence. Apatinib (YN968D1) is a small-molecule antiangiogenic agent that selectively inhibits VEGFR-2 and also mildly inhibits c-Kit and c-Src tyrosine kinases, abundant in invasive pituitary adenomas. CASE PRESENTATION:present a 41-year-old female with a growth hormone (GH)-secreting invasive pituitary adenoma causing menstrual disorder and headache symptoms. Over three years, she underwent four surgeries and a stereotactic radiosurgery, but the results were poor. Two months after the fourth operation, she started treatment with temozolomide (200mg/m2, d1-5, 28d, orally) and apatinib (0.425g, daily, orally). Her GH level dropped to normal with a >90% decrease in tumor size, after 1-year treatment. There was no evidence of recurrence by imaging or by serum GH levels over 31.5 months of follow-up. CONCLUSION:we successfully treated this patient with recurrent invasive pituitary adenoma with temozolomide and apatinib for 31.5 months without recurrence. Angiogenesis is an active process in the cases of invasive pituitary adenomas that cannot be controlled by conventional therapy.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Wang Y,He Q,Meng X,Zhou S,Zhu Y,Xu J,Tao Rdoi
10.1016/j.wneu.2018.12.174subject
Has Abstractpub_date
2019-01-10 00:00:00eissn
1878-8750issn
1878-8769pii
S1878-8750(19)30044-0pub_type
杂志文章abstract：BACKGROUND:Asymptomatic or minor symptom meningiomas (AMSMs) in the elderly are incidental findings, with no consensus reached on the optimal management strategy. In the present study, we aimed to determine the surgical risk factors for elderly patients with AMSMs using a nationwide registry database in Japan. METHODS...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2021.01.001
更新日期：2021-01-11 00:00:00
abstract：OBJECTIVE:This study was designed to assess the impact of public health policy in Australia in response to the coronavirus disease identified in 2019 (COVID-19) pandemic on the delivery of neurosurgical services. Being essential services, we postulated that there would not be a decrease in elective and emergency neuros...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2020.05.136
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Cerebral vasospasm is an important cause of morbidity after subarachnoid hemorrhage, but can also occur after resection of acoustic neuroma. This study aimed to identify factors associated with postoperative cerebral vasospasm in patients with acoustic neuroma. METHODS:This was a retrospective analysis of p...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.07.016
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the microsurgical anatomy of the fiber tract connections of the supplementary motor area (SMA) and pre-SMA, and examine its potential functional role with reference to clinical trials in the literature. METHODS:Ten postmortem formalin-fixed human brains (20 sides) and 1 cadaveric head were prepar...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.07.072
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:Intradural spinal arachnoid cysts (SACs) are among many etiologies for syringomyelia. Consequentially, neurologic symptoms arise such as pain, gait disturbance, and bladder dysfunction. Identification of SAC on magnetic resonance imaging (MRI) can be challenging, as SACs can be fenestrated or in the form o...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.11.004
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented challenge. Different models of reorganization have been described aiming to preserve resources and ensure optimal medical care. Limited clinical neurosurgical experience with patients with COVID-19 has been reported. We share organizational...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.08.168
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Intracranial hemorrhage can be a devastating complication of endovascular thrombectomy (ET) after acute ischemic stroke increasing disability and mortality. Patients with low platelet count were excluded from major ET trials. This study explores the association between platelet count and intracranial hemorrh...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.036
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To investigate potential health care discrepancies in patients with ruptured cerebral aneurysms undergoing microsurgical intervention. METHODS:We retrospectively reviewed patients with ruptured intracranial aneurysms treated at our tertiary referral university hospital (UH) and safety net county hospital (CH...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.03.087
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Affective symptoms are frequent in patients with brain tumors. The origin of such symptoms is unknown; either focal brain injury or reactive emotional distress may be responsible. This cross-sectional pilot study linked depressive symptoms and anxiety to white matter integrity. The objective was to test the ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.05.031
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:To compare the treatment results between 1-level vertebral column decancellation (VCD) and pedicle subtraction osteotomy (PSO) for correcting severe kyphotic deformity in ankylosing spondylitis (AS). VCD and PSO have been used to correct AS-related kyphotic deformity, but the differences on correcting results...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.011
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess nasal morbidity of endoscopic transsphenoidal approaches (ETAs) for treatment of sellar and parasellar diseases through evaluation of quality of life (QoL) and nasal function. The impact of different ETAs, according to extent and reconstruction technique, was also studied. ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.11.212
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Intradiploic epidermoid cyst (IEC) concurrent with chronic epidural hematoma (CEDH) has never been reported in the literature. We report a unique case of IEC concurrent with anatomically close associated CEDH. CASE DESCRIPTION:A 54-year-old man presented with a 1-week history of headache, confusion, and dro...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.030
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Seizure is the second-most common presentation in patients with arteriovenous malformations (AVMs) and superimposes a significant burden on pediatric patients. Postoperative seizure risk in unruptured AVMs is underreported in the pediatric AVM literature. We aimed to characterize and identify predictive fact...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.031
更新日期：2017-09-01 00:00:00
abstract：:Military explorations of the practical role of simulators have served as a driving force for much of the virtual reality technology that we have today. The evolution of 3-dimensional and virtual environments from the early flight simulators used during World War II to the sophisticated training simulators in the moder...
journal_title：World neurosurgery
pub_type： 历史文章,杂志文章
doi：10.1016/j.wneu.2012.06.014
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:X-linked hypophosphatemia (XLH) is the most common inherited form of renal phosphate wasting and inherited rickets. Patients have hyperplasia of fibrochondrocytes in tendons and ligaments, causing the structures to thicken and calcify. Thickening of the lamina, hypertrophy of facet joints, and calcification ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.07.076
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Brain abscesses are well-known to neurologic surgeons with well-recognized presentations, which include seizures, neurologic deficit, and headache. Rare symptoms may lead to a delay in diagnosis, which can be life threatening in the setting of a brain abscess. CASE DESCRIPTION:We present the case of a 46-ye...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.139
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:We aimed to identify the factors that can predict the risk of occipital lobe damage preoperatively when resecting tumors located at the tentorial or pineal regions with the occipital-transtentorial approach (Poppen approach). METHODS:In 27 consecutive patients who underwent tumor resection with the Poppen ap...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.08.013
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Anterior lumbar interbody fusion (ALIF) is a surgical technique used to treat patients with a variety of lumbar pathologies. Identification of risk factors leading to complication following ALIF surgery may allow surgeons to better judge candidacy and optimize care for high-risk patients. METHODS:A retrospe...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.056
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Hiccups are a well-known short-term phenomenon in daily life. If they persist or become intractable, they may be a primary symptom of a disease. Recent studies identified the medulla oblongata as the neuroanatomic center of the hiccup reflex arc. In previous cases, an isolated lesion at the dorsal side of th...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.06.013
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:Although a number of studies have implicated ischemia and hypoxia in the pathogenesis of cervical spondylosis, quantification remains difficult and the role of ischemia and hypoxia on disease progression and disease severity in human cervical spondylosis remains largely unknown. Therefore, the objective of t...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.253
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To explore influence of reduction of slippage on radiologic parameters, clinical outcomes, and perioperative complications in treatment of grade II/III lumbar isthmic spondylolisthesis. METHODS:We divided 156 patients with grade II/III spondylolisthesis into 2 groups with preoperative balanced or unbalanced ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.217
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:Patients with neurofibromatosis type 2 (NF2) are prone to develop multiple intracranial neoplasms, such as schwannomas of the cranial nerves and meningiomas. The aim of our study was to investigate 1) the median growth rate per year, 2) the growth-free interval, and 3) the growth patterns of NF2-associated in...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.10.060
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:Several studies have looked for an association between radiologic findings and neurologic outcome after cervical trauma. In the current literature, there is a paucity of evidence proving the prognostic role of soft tissue damage or bony integrity. Our objective is to determine radiologic findings related to n...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.02.034
更新日期：2017-05-01 00:00:00
abstract：:Exercise, diet, and personal fitness programs are essentially lacking in modern graduate medical education. In the context of long hours and alternating shift and sleep cycles, the lack of exercise and poor dietary choices may have negative consequences on physician physical and mental health. This opinion piece aims ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.024
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Brain aneurysms (BAs) are the most common intracranial vascular condition, with an overall incidence of 1%-2%. Among the common causes of their initial formation and growth, the role of radiation therapy (RT) has been reported in some studies. The aim of the present study is to report the most relevant featu...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2019.09.157
更新日期：2020-03-01 00:00:00
abstract：:Recent approval of unprecedented gene therapies has signaled the beginning of a new era in modern medicine. This rapidly changing landscape underscores the importance of neurosurgeons developing a fundamental understanding of gene therapy, because many neurologic disorders are caused by derangements in gene expression...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.09.097
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:We performed a rigorous statistical analysis of the complications and outcomes of patients with ruptured or unruptured intracranial aneurysms. Our emphasis was on the potential predictive factors when both surgical and endovascular management are offered by a team with balanced microsurgical and endovascular...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.10.094
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:Preoperative embolization may facilitate skull base meningioma resection, but its safety and efficacy in the Onyx era have not been investigated. In this retrospective cohort study, we evaluated the outcomes of preoperative embolization of skull base meningiomas using Onyx as the primary embolysate. METHODS:...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.208
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:In children, decompressive craniectomy is commonly performed in cases of increased intracranial pressure that is not medically managed. Currently, it is standard practice to perform cranioplasty after decompressive craniectomy, although optimal timing for the procedure remains controversial. To date, few stu...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.085
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Transforaminal endoscopic lumbar discectomy (TELD), a minimally invasive spinal technique, has advantages over open discectomy. Unilateral TELD for disc herniation causing bilateral symptoms is challenging. In this study, we describe a percutaneous endoscopic herniotomy technique by using a unilateral approa...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.06.191
更新日期：2017-10-01 00:00:00
