Abstract：
:Recent approval of unprecedented gene therapies has signaled the beginning of a new era in modern medicine. This rapidly changing landscape underscores the importance of neurosurgeons developing a fundamental understanding of gene therapy, because many neurologic disorders are caused by derangements in gene expression. Gene therapy, the transfer of genetic material to alter endogenous gene expression or introduce exogenous genes, has emerged as a novel therapeutic approach to treat a wide range of diseases. There are several methods to transfer genetic material to the nervous system through viral transduction. Here, we synthesize the latest developments in gene therapy for neurologic disorders and the neurosurgical approaches to treat them.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Hitti FL,Gonzalez-Alegre P,Lucas THdoi
10.1016/j.wneu.2018.09.097subject
Has Abstractpub_date
2019-01-01 00:00:00pages
261-273eissn
1878-8750issn
1878-8769pii
S1878-8750(18)32143-0journal_volume
121pub_type
杂志文章,评审abstract：OBJECTIVE:Ultrasound volume navigation (UVN) has been widely used for accurate guidance and decreased radiation exposure. However, few studies have focused on the clinical significance of UVN in guiding percutaneous puncture in percutaneous transforaminal endoscopic discectomy (PTED). We evaluated UVN to guide percutan...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.07.185
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Patients with single brain metastasis (SBM) have better outcomes after stereotactic radiosurgery (SRS). We analyzed our SRS database to evaluate possible prognostic factors in patients with SBM. METHODS:A total of 584 patients with SBM were treated with SRS at our institution (2000-2012). Study end points w...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.04.156
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:Previous studies have suggested that postoperative hypopituitarism in patients with nonsellar intracranial tumors is caused by traumatic surgery. However, with development of minimally invasive and precise neurosurgical techniques, the degree of injury to brain tissue has been reduced significantly, especiall...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.03.116
更新日期：2017-09-01 00:00:00
abstract：INTRODUCTION:Vertebral compression fractures are a common clinical occurrence in elderly individuals with osteoporosis. No current evidence exists on risk factors and clinical impact of discharge to inpatient (IP) care facility after vertebral augmentation procedures. MATERIALS AND METHODS:The 2012-2014 American Colle...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2018.06.221
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Endoscopic surgery for lumbar stenosis is gaining acceptance because of the minimal muscle damage, short recovery times, reduced blood loss, and good clinical results. We report a novel technique of decompressing contralateral traversing and exiting nerve roots through a single interlaminar window, avoiding ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.111
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Anatomical barriers (e.g., pedicles, narrow foramina) can hinder direct access to, and removal of, disc fragments that have migrated far downward. Using transforaminal full-endoscopic lumbar discectomy (FELD), we devised a modified technique, the suprapedicular retrocorporeal approach, for herniations in whic...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.08.038
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:To investigate the extent of spinal cord compression and cerebrospinal fluid (CSF) space after T9 paddle lead spinal cord stimulation (SCS) using three-dimensional myelographic computed tomography scans. METHODS:Preoperative and postoperative three-dimensional myelographic computed tomography scans were per...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.186
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Work hour restrictions and current quality, financial, and legal concerns have reduced resident operative volume and autonomy. Although laboratory (cadaveric or animal) dissection has a rich history in neurosurgery, its current role in resident training is unclear. Recent literature suggests educators have lo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.05.028
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:Two main types of embolic protection devices have been used during carotid artery stenting (CAS): distal protection devices (DPDs) and proximal protection devices (PPDs). We compared the complications, clinical outcomes, and new ischemic lesions on diffusion-weighted magnetic resonance imaging (DWI) studies b...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.12.121
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:The prognosis for patients with glioblastoma depends particularly on the degree of tumor resection. Patients with tumor remnants in postsurgical magnetic resonance imaging (<72 hours) may benefit from early reoperation. We present our results concerning the impact on overall survival (OS) and progression-fre...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.04.072
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:The true incidence of perioperative coronavirus disease 2019 (COVID-19) has not been well elucidated in neurosurgical studies. We reviewed the effects of the pandemic on the neurosurgical case volume to study the incidence of COVID-19 in patients undergoing these procedures during the perioperative period and...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.08.015
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Orbital arteriovenous fistula (AVF) is a rare entity with only 17 cases reported so far. An arteriovenous hemangioma is a distinct entity of an angioma that most frequently affects the skin. However, to our knowledge, there has not been a case arising in the orbit. CASE DESCRIPTION:A previously healthy, 73-...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.11.003
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:In his 1938 monograph, Cushing tabulated 313 meningioma cases treated throughout his career at the Johns Hopkins and the Peter Bent Brigham Hospitals. Of these, 18 patients were treated at the Johns Hopkins Hospital. Cushing provided basic demographic, perioperative, and outcomes data in his tables, but the ...
journal_title：World neurosurgery
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.wneu.2011.08.021
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Cone beam computed tomography (CBCT) imaging is used commonly in neurointerventional surgery for rapid intraprocedural assessment and planning of intracranial interventions. Our goal was to evaluate the ability of immediate postprocedural CBCT scan in assessing potential complications in pediatric patients. ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.12.003
更新日期：2020-03-01 00:00:00
abstract：:Pituicytomas are rare low-grade glial lesions of neurohypophysis or adenohypophysis. They are often misdiagnosed as adenomas due to their similar morphology. Previous reports have underlined their nonspecific aspect. In our experience, presence of flow voids on magnetic resonance, which usually indicate hypervasculari...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.10.036
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Cavernous hemangiomas account for 5%-13% of central nervous system vascular lesions. They are usually found intra-axially but rarely involve extra-axial structures, most commonly the middle cranial fossa. A cavernous hemangioma manifesting as a clinoid meningioma is extremely rare. CASE DESCRIPTION:A 36-yea...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.02.029
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Metastatic meningiomas (MMs) are rare (0.1 of 100 cases). Their treatment requires a multimodal approach, with surgery, radiotherapy, chemotherapy, and radiosurgery, which allows a long-term local control (LC) and an extension of free survival. In this study, the authors performed a review of the literature ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.05.058
更新日期：2019-08-01 00:00:00
abstract：INTRODUCTION:Evidence regarding whether the polyaxial pedicle screws at the upper instrumented vertebrae (UIV) are superior to monoaxial pedicle screws in prevention of proximal junctional kyphosis (PJK) is not clear. The aim of this study was therefore to explore the influence of different types of pedicle screws at U...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.02.013
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:Spine trauma management in children varies from one team to another, and to date, no clear consensus has been reached. The goal of this study was to describe the epidemiology of spine trauma in children and evaluate the timing and techniques of surgery when it was required. METHODS:A retrospective review of ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.134
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:For many years, the microsurgical transoral approach has been accepted as the gold standard for anterior decompressions of the craniovertebral junction (CVJ). The introduction of the endoscopic endonasal approach (EEA) has gained wide recognition and overwhelming support in recent years, including for disease...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.01.099
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Staphylococcus lugdunensis is a coagulase-negative staphylococcus with aggressive and rapidly progressive infectious behavior. This organism has emerged as an important pathogen implicated in both community-acquired and nosocomial infections, including meningitis, brain abscess, catheter-related bacteremia, ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2013.01.046
更新日期：2013-12-01 00:00:00
abstract：:An elderly woman was transferred for biopsy of a pontine lesion. Her condition, including gait disturbances, truncal ataxia, and dysarthria-presumed to be due to severe alcohol abuse-had deteriorated during treatment of ambulatory-acquired pneumonia. No electrolyte abnormalities were noted during hospitalization. Howe...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.05.061
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Lumbar arthrodesis is a surgical option for treatment of lumbar pathologies. Stability of the spinal construct partly depends on load-bearing support from back muscles. Despite the role of the psoas muscle in upright spinal stabilization, data describing its clinical significance are scarce. We evaluated the...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.11.022
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:Because of the balance between achieving complete seizure freedom and minimizing the postoperative neurologic deficits, surgery for refractory epilepsy originating from the primary motor cortex is difficult. Here, we report the outcomes of surgery for magnetic resonance imaging-negative refractory epilepsy or...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.02.090
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:Several studies have looked for an association between radiologic findings and neurologic outcome after cervical trauma. In the current literature, there is a paucity of evidence proving the prognostic role of soft tissue damage or bony integrity. Our objective is to determine radiologic findings related to n...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.02.034
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:Brain tumors are rare in infants who are younger than six months of age. These tumors can be challenging to treat surgically. We analyzed a modern series of patients treated by a multidisciplinary team at a tertiary care center and performed a literature review of this unique population. METHODS:Retrospectiv...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2011.09.012
更新日期：2012-07-01 00:00:00
abstract：:Traumatic brain injury (TBI) represents a major public health concern worldwide, with no significant change in its epidemiology over the last 30 years. After TBI, the primary injury induces irreversible brain damage, which is untreatable. The subsequent secondary injury plays a critical role in the clinical prognosis ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.07.082
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:There is accumulating evidence of a potential beneficial effect of early surgical intervention after acute cervical spinal cord injury (SCI). However, around one third of all SCIs affect the thoracic spine. This cohort has not been extensively investigated, mainly because of less sensitive clinical readout m...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.11.015
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:Transmission of knowledge to neurosurgical trainees in any environment is challenging, more so, in the developing world. Online education has the potential to maximize the cooperation within the international neurosurgical community. Our objective is to describe a model of online education that is sustainable...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.02.041
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:To investigate the incidence, distribution characteristics, and radiographic features of the ossification of the posterior longitudinal ligament (OPLL) combined with ossification of the nuchal ligament (ONL) and to analyze the correlation between the location of ONL and degree of ossification in patients with...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.130
更新日期：2018-08-01 00:00:00
