Abstract：
OBJECTIVE:Patients with neurofibromatosis type 2 (NF2) are prone to develop multiple intracranial neoplasms, such as schwannomas of the cranial nerves and meningiomas. The aim of our study was to investigate 1) the median growth rate per year, 2) the growth-free interval, and 3) the growth patterns of NF2-associated intracranial tumors. METHODS:All available magnetic resonance (MR) images of patients from the regional neurofibromatosis center were collected. The depicted tumors' volumes were then calculated if the tumors met the following inclusion criteria: contrast enhanced T1-weighted MRI datasets had to be available from at least two investigations and tumors had to be measurable on at least two slices. RESULTS:One-hundred and eighty-eight tumors from 52 patients (20 male, 32 female) met the inclusion criteria for volumetric analysis. Overall, the median follow-up time was 76.5 months per patient (range 13-199 months). After 5 years, the median tumor size was 196% ± 338% for vestibular schwannomas (VS), 204% ± 702% meningiomas (M), 128% ± 64.9% for non-vestibular schwannomas (NVS) and 139% ± 270% for pre-operated tumors of the cerebellopontine angle (TX), respectively. The median time to 20% tumor progression was 21 months for VS, NVS and TX, and 17 months for M. Overall, saltatory growth was the most common growth pattern (46.9%). CONCLUSIONS:Most NF2-associated tumors display a saltatory growth pattern. Meningiomas and untreated vestibular schwannomas grow rapidly and overall at similar rates. Tumors of the CPA that have been operated on and non-vestibular schwannomas show less relative growth per year.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Lawson McLean AC,Rosahl SKdoi
10.1016/j.wneu.2016.10.060subject
Has Abstractpub_date
2017-02-01 00:00:00pages
152-161eissn
1878-8750issn
1878-8769pii
S1878-8750(16)31049-Xjournal_volume
98pub_type
杂志文章abstract：BACKGROUND:One of the main challenges during skull base tumor surgery is identifying the relationships between the lesion and the principal intracranial vessels. To this end, neuronavigation systems based on preoperative imaging lack accuracy because of brain shift and brain deformation. Intraoperative navigated B-mode...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.07.025
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abstract：BACKGROUND:Burst fractures account for more than half of all thoracolumbar fractures and are frequently associated with spine instability and neurological deficit. The anterior approach is favored when decompression of the spinal canal is necessary. We compare two commonly available struts used for anterior approach af...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2010.09.018
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journal_title：World neurosurgery
pub_type： 临床试验,杂志文章
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更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Although targeted by radiotherapy, recurrence in glioblastoma occurs mainly periresectionally owing to tumor infiltration. An increase in the apparent diffusion coefficient (ADC) has been shown in the large high-T2 area on magnetic resonance imaging posttreatment; however, until now ADC has not been investig...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.129
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abstract：BACKGROUND:Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes. This ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2011.07.014
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abstract：BACKGROUND:Parasagittal meningioma (PSM) has a high incidence of peritumoral edema and unclear pathogenesis. The venous compression theory has been proposed as a pathomechanism; however, this is controversial, and the various edema patterns have not been recognized. OBJECTIVE:We sought to establish the relationship be...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.092
更新日期：2018-07-01 00:00:00
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journal_title：World neurosurgery
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doi：10.1016/j.wneu.2020.06.041
更新日期：2020-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.06.022
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:Hemangioblastomas remain a surgical challenge because of their arteriovenous malformation-like character. Recently, indocyanine green (ICG) videoangiography has been applied to neurosurgical vascular surgery. The aim of this study was to evaluate the usefulness of tumor blood flow imaging by intraoperative IC...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2013.02.009
更新日期：2014-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.052
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Lumbar puncture is a common procedure that can be safely performed in most patients. Certain populations may have increased risk for complications following lumbar puncture, but the significance of basilar invagination is often underappreciated. CASE DESCRIPTION:A 45-year-old woman with basilar invagination...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.02.040
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:A Direct Aspiration First Pass Technique is one of the most widely used techniques in mechanical thrombectomy. Aspiration catheter size plays a major role in the success of this technique. The AXS Vecta (Stryker Neurovascular, Fremont, California, USA) aspiration catheter is the first approved 0.071-inch c...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.055
更新日期：2019-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.02.107
更新日期：2020-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.04.114
更新日期：2018-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.235
更新日期：2019-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.01.023
更新日期：2016-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.07.019
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:Fluorescence guidance has a demonstrated potential in maximizing the extent of high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5-aminolevulinic acid (5-ALA) and fluorescein, have been examined with the use of several imaging techniques. Our goal was to review the state ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2013.06.014
更新日期：2014-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.05.004
更新日期：2019-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.09.031
更新日期：2020-12-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.195
更新日期：2018-12-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.06.159
更新日期：2019-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2018.02.183
更新日期：2018-06-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2021-01-11 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.162
更新日期：2017-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2015.06.005
更新日期：2015-10-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.12.150
更新日期：2021-01-05 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2019.03.237
更新日期：2019-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.12.036
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:To assess efficacy of immersive virtual reality (VR) surgical simulator training for pedicle screw placement (PSP) in surgical graduate students. METHODS:Sixteen inexperienced surgical graduate students were equally randomly assigned to an experimental group (VR group) and a control group (non-VR group). Stude...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.090
更新日期：2018-12-28 00:00:00
