Abstract：
:Probiotics have always been considered as a supplementary therapy for many diseases especially gut disorders. The absorption and barrier function of the gut play a vital role in the maintenance of body homeostasis. This study was to investigate the protective effects of Bacillus amyloliquefaciens SC06 (Ba) on H2O2-induced oxidative stress on intestinal porcine epithelial cells (IPEC-1) based on the level of gene expression. We demonstrated that Ba was a safe probiotic strain in the first place. Results showed that treatment with H2O2 significantly increased the mRNA expression of absorptive transporters glucose transporter 2 (GLUT2), Ala/Ser/Cys/Thr transporter 1 (ASCT1), and ASCT2 compared with the control group. Meanwhile, oxidative stress induced a significant improvement in the mRNA expression of occludin (OCLN) and caspase-3, and remarkably inhibited the expression of L-type amino acid transporter 1 (LAT1) or B cell lymphoma-2 (Bcl-2), respectively. Pretreatment with Ba dramatically reversed the disturbance induced by oxidative stress on the mRNA expression of ASCT1, ASCT2, and OCLN, which also significantly prevented H2O2-inhibited LAT1 and Bcl-2 mRNA expression. However, Ba failed to exert any significant protective effect on GLUT2 and caspase-3 mRNA expression. We concluded that pretreatment with Ba could alleviate the damage caused by oxidative stress to a certain extent and conferred a protective effect to the intestine.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Wu Y,Xu H,Cao X,Liu R,Tang L,Zeng Z,Li Wdoi
10.1007/s12602-019-09538-5subject
Has Abstractpub_date
2020-06-01 00:00:00pages
649-656issue
2eissn
1867-1306issn
1867-1314pii
10.1007/s12602-019-09538-5journal_volume
12pub_type
杂志文章abstract：:Dental diseases are among the common health issues experienced around the world. Dental caries is one of the most predominant oral diseases worldwide. Major factors associated with caries development include poor oral hygiene, the content of specific carbohydrates in the diet, dental biofilm formation, the cariogenic ...
journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章,评审
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journal_title：Probiotics and antimicrobial proteins
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更新日期：2012-06-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
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pub_type： 杂志文章
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-020-09740-w
更新日期：2021-01-17 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-009-9024-9
更新日期：2010-03-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-019-09557-2
更新日期：2020-06-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
abstract：:The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below. ...
journal_title：Probiotics and antimicrobial proteins
pub_type： 已发布勘误
doi：10.1007/s12602-018-9412-0
更新日期：2019-06-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2020-06-30 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-019-09556-3
更新日期：2020-06-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-019-09597-8
更新日期：2020-09-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-018-9462-3
更新日期：2019-09-01 00:00:00
abstract：:In the present study, the ability of bovine lactoferrin hydrolysate (LfH) to disrupt the cytoplasmic membrane of Escherichia coli O157:H7 was investigated. Lactoferrin and LfH antimicrobial activities were compared against E. coli O157:H7 and E. coli O157:H7 spheroplasts. The effect of LfH on the cytoplasmic membrane ...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-010-9039-2
更新日期：2010-06-01 00:00:00
