Abstract：
:Medically induced loss of consciousness (mLOC) during anesthesia is associated with a macroscale breakdown of brain connectivity, yet the neural microcircuit correlates of mLOC remain unknown. To explore this, we applied different analytical approaches (t-SNE/watershed segmentation, affinity propagation clustering, PCA, and LZW complexity) to two-photon calcium imaging of neocortical and hippocampal microcircuit activity and local field potential (LFP) measurements across different anesthetic depths in mice, and to micro-electrode array recordings in human subjects. We find that in both cases, mLOC disrupts population activity patterns by generating (1) fewer discriminable network microstates and (2) fewer neuronal ensembles. Our results indicate that local neuronal ensemble dynamics could causally contribute to the emergence of conscious states.
journal_name
Cell Systjournal_title
Cell systemsauthors
Wenzel M,Han S,Smith EH,Hoel E,Greger B,House PA,Yuste Rdoi
10.1016/j.cels.2019.03.007subject
Has Abstractpub_date
2019-05-22 00:00:00pages
467-474.e4issue
5eissn
2405-4712issn
2405-4720pii
S2405-4712(19)30077-8journal_volume
8pub_type
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