Abstract：
:The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability.
journal_name
Cell Systjournal_title
Cell systemsauthors
Keenan AB,Jenkins SL,Jagodnik KM,Koplev S,He E,Torre D,Wang Z,Dohlman AB,Silverstein MC,Lachmann A,Kuleshov MV,Ma'ayan A,Stathias V,Terryn R,Cooper D,Forlin M,Koleti A,Vidovic D,Chung C,Schürer SC,Vasiliauskas J,doi
10.1016/j.cels.2017.11.001subject
Has Abstractpub_date
2018-01-24 00:00:00pages
13-24issue
1eissn
2405-4712issn
2405-4720pii
S2405-4712(17)30490-8journal_volume
6pub_type
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