Abstract：
:Establishing a quantitative connection between the population growth rate and the generation times of single cells is a prerequisite for understanding evolutionary dynamics of microbes. However, existing theories fail to account for the experimentally observed correlations between mother-daughter generation times that are unavoidable when cell size is controlled for, which is essentially always the case. Here, we study population-level growth in the presence of cell size control and corroborate our theory using experimental measurements of single-cell growth rates. We derive a closed formula for the population growth rate and demonstrate that it only depends on the single-cell growth rate variability, not other sources of stochasticity. Our work provides an evolutionary rationale for the narrow growth rate distributions often observed in nature: when single-cell growth rates are less variable but have a fixed mean, the population will exhibit an enhanced population growth rate as long as the correlations between the mother and daughter cells' growth rates are not too strong.
journal_name
Cell Systjournal_title
Cell systemsauthors
Lin J,Amir Adoi
10.1016/j.cels.2017.08.015subject
Has Abstractpub_date
2017-10-25 00:00:00pages
358-367.e4issue
4eissn
2405-4712issn
2405-4720pii
S2405-4712(17)30387-3journal_volume
5pub_type
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