The burden of cancer attributable to modifiable risk factors in Canada: Methods overview.

Abstract:

:Up-to-date estimates of current and projected future cancer burden attributable to various exposures are essential for planning and implementing cancer prevention initiatives. The Canadian Population Attributable Risk of Cancer (ComPARe) study was conducted to: i) estimate the number and proportion of cancers diagnosed among adults in Canada in 2015 that are attributable to modifiable risk factors and ii) project the future avoidable cancers by 2042 under various intervention targets. We estimated the population attributable risk (with 95% confidence intervals) and the potential impact fraction of cancers associated with selected lifestyle, environmental, and infectious factors. Exposure-specific sensitivity analyses were also completed where appropriate. Several exposures of interest included active and passive smoking, obesity and abdominal adiposity, leisure-time physical inactivity, sedentary behaviour, alcohol consumption, insufficient fruit and vegetable intake, red and processed meat consumption, air pollution (PM2.5, NO2), indoor radon gas, ultraviolet radiation (UVR), hepatitis B and C virus, Helicobacter pylori, Epstein-Barr virus, human papillomavirus, human herpesvirus type 8 and human T-cell lymphotropic virus type 1. We used the 2015 cancer incidence data for 35 cancer sites from the Canadian Cancer Registry and projected cancer incidence to 2042 using historical data from 1983 to 2012. Here, we provide an overview of the data sources and methods used in estimating the current and future cancer burden in Canada. Specific methodologic details for each exposure are included in the individual articles included as part of this special issue.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Brenner DR,Friedenreich CM,Ruan Y,Poirier AE,Walter SD,King WD,Franco EL,Demers PA,Villeneuve PJ,Grevers X,Nuttall R,Smith LM,Volesky KD,O'Sullivan DE,De P,ComPARe Study Team.

doi

10.1016/j.ypmed.2019.03.007

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

3-8

eissn

0091-7435

issn

1096-0260

pii

S0091-7435(19)30080-5

journal_volume

122

pub_type

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