Abstract:
:Information regarding cellular anti-senescence attributes of probiotic bacteria vis-à-vis modulation of senescence-associated secretory phenotype (SASP) and mTOR signaling is very limited. The present study assessed anti-senescence potential of secretory metabolites of probiotic Lactobacillus fermentum (Lact. fermentum) using H2O2-induced model of senescence in 3T3-L1 preadipocytes. Application of H2O2-induced cellular senescence characterized by increased cell size and SA-β-gal activity, activation of SASP and reactive oxygen species (ROS), DNA damage response and induction of cell cycle inhibitors (p53/p21WAF1/p16INK4a). Further, a robust stimulation of the PI3K/Akt/mTOR pathway and AMPK signaling was also observed in H2O2-treated cells. However, exposure of cells to cell-free supernatant of Lact. fermentum significantly attenuated phosphorylation of PI3K/Akt/mTOR pathway and alleviated senescence markers p53, p21WAF1, SA-β-gal, p38MAPK, iNOS, cox-2, ROS, NF-κB, and DNA damage response. These results provide evidence that secretory metabolites of Lact. fermentum can mitigate the development as well as severity of stress-induced senescence thereby indicating its utility for use as anti-aging or age-delaying agent.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Kumar R,Sharma A,Gupta M,Padwad Y,Sharma Rdoi
10.1007/s12602-019-09576-zsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
563-576issue
2eissn
1867-1306issn
1867-1314pii
10.1007/s12602-019-09576-zjournal_volume
12pub_type
杂志文章abstract::IL-17A is a cytokine which is produced by several immune and non-immune cells. The cytokine plays dual roles from protection from microbes and protection from pro-inflammatory based diseases to induction of the pro-inflammatory based diseases. The main mechanisms which lead to the controversial roles of IL-17A are yet...
journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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journal_title:Probiotics and antimicrobial proteins
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