Abstract：
:Proteomics involves large-scale comprehensive study of specific proteomes which have been widely used in the field of biomarker discovery, drug development, disease diagnosis and therapy. Comprehensive proteomics involve two or more proteomics approaches that are confirmatory, complementary, and/or synergistic. Obstructive sleep apnea (OSA) is a sleep disorder which causes respiratory cessation (due to upper airway collapse). Here we describe a comprehensive MS based label-free quantitative proteomic analysis of the OSA induced rat atria homogenates and matched controls by using 1 dimensional SDS PAGE (1-D PAGE) and 2 dimensional SDS PAGE (2-D PAGE) separation of the proteins, enzymatic digestion and analysis by nanoliquid chromatography tandem-mass spectrometry (LC-MS/MS). The outcomes from the 1D-PAGE and 2D-PAGE studies not only identified dysregulated proteins due to OSA, but also confirmed and complemented each other.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Channaveerappa D,Panama BK,Darie CCdoi
10.1007/978-3-030-15950-4_32subject
Has Abstractpub_date
2019-01-01 00:00:00pages
541-561eissn
0065-2598issn
2214-8019journal_volume
1140pub_type
杂志文章abstract：:Laser diffraction and photomicrography have been used to monitor sarcomere length changes in single muscle fibres of the frog, at long sarcomere lengths, during fixed end tetani. In the central 90% of all fibres, changes in sarcomere length were consistently less than 0.25 micron. Sarcomere length showed an initial ra...
journal_title：Advances in experimental medicine and biology
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abstract：:Exposure to sunlight is a major source of vitamin D for most people. Yet public health advice has focused overwhelmingly on avoiding exposure of unprotected skin because of the risks of erythema and skin cancer. Given that there are also health risks associated with low vitamin D status, we explore the possibilities o...
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journal_title：Advances in experimental medicine and biology
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更新日期：2012-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2002-01-01 00:00:00
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更新日期：2015-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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更新日期：1998-01-01 00:00:00
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更新日期：1998-01-01 00:00:00
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doi：10.1007/978-1-4419-9533-9_3
更新日期：2011-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4899-0405-8_6
更新日期：1987-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/978-1-4615-5347-2_10
更新日期：1998-01-01 00:00:00
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-1-4615-2946-0_38
更新日期：1993-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2017-01-01 00:00:00
abstract：:It is now well established that oxytocin is present in the mammalian testis and there is growing evidence that the peptide plays a role in the male reproductive tract by both assisting sperm transport and modulating steroidogenesis. In the testis, oxytocin has been shown not only to modulate testosterone production bu...
journal_title：Advances in experimental medicine and biology
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doi：
更新日期：1995-01-01 00:00:00
abstract：:Studies of ambient noise south of Australia show higher levels at low frequencies in the deep water off the continental shelf compared with locations on the shelf. The difference arises because of differences in transmission loss. Marine animals would experience significantly different noise levels and directionality ...
journal_title：Advances in experimental medicine and biology
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更新日期：2016-01-01 00:00:00
abstract：:In this chapter, we intend to review gene therapy concepts applied to the potential treatment of tyrosinemia for parents and pediatricians. Therefore, our main objective is to give general informations in a comprehensible manner. Considering the nature of tyrosinemia and the current state of technology, a particular f...
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更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-5766-7_41
更新日期：1990-01-01 00:00:00
abstract：:Fluorodeoxyuridylate (FdUMP) and thymidylate synthase (TS) are one of the better understood systems of drug-target interaction in cancer chemotherapy. Isolation and characterization of TS (initially from Lactobacillus casei and later from a variety of other sources), cloning and sequencing of the gene, determination o...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4684-5607-3_1
更新日期：1988-01-01 00:00:00
abstract：:Previous modeling efforts suggest that myoglobin-facilitated diffusion contributes very little to oxygen transport in a Krebs-Henseleit perfused isolated heart when literature-derived values for the diffusion coefficient of myoglobin (DMb) were used. Simulations have strongly suggested that the contractile mechanisms ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-4863-8_61
更新日期：1998-01-01 00:00:00
abstract：:During 1980 to 1983, 40 patients with advanced or locally recurrent breast cancer were treated with the thermo-radiotherapy. Ten of these were primary cases and 30 recurrent. In 23 patients who had 2 to 3 lesions. Altogether there were 64 lesions treated. Combined thermo-radiotherapy was applied to the bigger lesions ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-5766-7_56
更新日期：1990-01-01 00:00:00
