The role of adjuvant chemotherapy in stage II and III mucinous colon cancer.

Abstract:

INTRODUCTION:Mucinous adenocarcinoma is a subtype of colonic adenocarcinoma associated with worse survival compared to nonmucinous adenocarcinoma. Prior studies on the effect of chemotherapy on survival in mucinous adenocarcinoma have shown mixed results. The aim of this study is to evaluate the effect of chemotherapy on the survival of patients with stage II and III mucinous adenocarcinoma. METHODS:The National Cancer Database was used to identify patients diagnosed with stage II or III nonmucinous adenocarcinoma or mucinous adenocarcinoma between 2004 and 2016. The primary outcome was overall survival. RESULTS:Fourteen thousand and three hundred patients with stage II mucinous colon adenocarcinoma and 16 741 patients with stage III mucinous colon adenocarcinoma were identified. There was no significant difference in survival between nonmucinous adenocarcinoma and mucinous adenocarcinoma patients in adjusted analysis for stage II disease (HR:1.00, 95%CI:0.98-1.02, P = .99), but there was a significant difference for stage III disease (HR:1.05, 95%CI:1.03-1.07, P < .001). In propensity-matched cohorts of patients with mucinous adenocarcinoma, chemotherapy was significantly associated with survival in stage II (HR:0.79, 95%CI:0.69-0.90, P < .001) and stage III disease (HR:0.56, 95%CI:0.52-0.60, P < .001). CONCLUSIONS:Patients with stage II or stage III mucinous adenocarcinoma of the colon who are given adjuvant chemotherapy have significantly improved survival compared to patients not given chemotherapy.

journal_name

J Surg Oncol

authors

Fields AC,Lu P,Goldberg J,Irani J,Bleday R,Melnitchouk N

doi

10.1002/jso.25705

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1190-1200

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

120

pub_type

杂志文章
  • Preoperative chemotherapy followed by mastectomy for locally advanced breast cancer.

    abstract::Six patients with advanced local-regional breast cancer were reviewed. Five out of the six patients previously had had radiation therapy as part of the initial therapy. All patients had preoperative cycles of combination chemotherapy, either CMF or CAF. The two stage III patients had greater than 75% reduction in meas...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220415

    authors: Schick P,Goodstein J,Moor J,Butler J,Senter KL

    更新日期:1983-04-01 00:00:00

  • Surgical management of GIST and intra-abdominal visceral leiomyosarcomas.

    abstract::Intra-abdominal visceral sarcomas are a rare group of mesenchymal tumors that require the use of distinct surgical principles and a multidisciplinary approach in order to optimize treatment. Surgery remains the only potentially curative treatment. Management and outcomes vary for the different sarcomas arising from vi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23803

    authors: Fairweather M,Raut CP

    更新日期:2015-04-01 00:00:00

  • MR lymphangiography in the treatment of lymphedema.

    abstract::Lymphedema is a common condition frequently seen in cancer patients who have had lymph node dissection +/- radiation treatment. Traditional management is mainly non-surgical and unsatisfactory. Surgical treatment has relied on excisional techniques in the past. Physiologic operations have more recently been devised to...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.24337

    authors: Neligan PC,Kung TA,Maki JH

    更新日期:2017-01-01 00:00:00

  • Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs).

    abstract:BACKGROUND:The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease-free survival after curative resection of the primary tumor without adjuvant systemic therapy. METHODS:Paraffin-embedded tumor secti...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21905

    authors: Kern A,Görgens H,Dittert DD,Krüger S,Richter KK,Schackert HK,Saeger HD,Baretton G,Pistorius S

    更新日期:2011-07-01 00:00:00

  • Is gastrectomy mandatory for all residual or recurrent gastric cancer following endoscopic resection? A large-scale Korean multi-center study.

    abstract:BACKGROUND AND OBJECTIVES:To clarify optimal treatment guidelines for residual or local recurrence after endoscopic resection (ER). METHODS:Eighty-six patients underwent gastrectomy due to incomplete ER and local recurrence after ER. The pathological findings of ER and gastrectomy specimens were analyzed. RESULTS:The...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/jso.21074

    authors: Song KY,Hyung WJ,Kim HH,Han SU,Cho GS,Ryu SW,Lee HJ,Kim MC,Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) Group.

    更新日期:2008-07-01 00:00:00

  • Appraisal of disease-specific benefits of minimally invasiveness in surgery of breast cancer liver metastases.

    abstract:BACKGROUND:The primary endpoint of this study is to analyze short term benefit of laparoscopic approach (minimally invasive liver surgery [MILS]) over the open techniques in patients submitted to surgery for breast cancer liver metastases (BCLM) within a disease-specific perspective. MATERIAL AND METHODS:A group of 30...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25702

    authors: Ratti F,Serenari M,Zanello M,Prosperi E,Cipriani F,Ercolani G,Jovine E,Cescon M,Aldrighetti L

    更新日期:2019-12-01 00:00:00

  • Perspectives on lymphangiogenesis and angiogenesis in cancer.

    abstract::Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are al...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21808

    authors: Holopainen T,Bry M,Alitalo K,Saaristo A

    更新日期:2011-05-01 00:00:00

  • Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients. METHODS:One hundred and forty one cases of NPC and 25 normal tissues...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21728

    authors: Liao B,Zhong BL,Li Z,Tian XY,Li Y,Li B

    更新日期:2010-12-01 00:00:00

  • Immunohistochemically demonstrated expression of HLA-DR antigen in colorectal adenocarcinomas and its relation to clinicopathological features.

    abstract::We studied 148 colorectal adenocarcinomas to clarify any correlation between HLA-DR antigen expression on tumor cells and histopathological features. Paraffin sections of formalin-fixed tissues were stained with HLA-DR antigen using the indirect immunoperoxidase technique. All the tumor tissues were divided into two g...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930590407

    authors: Morita M,Tanaka K,Kawanishi H,Tsuji M,Ookusa T,Takada H,Okamura A,Hioki K

    更新日期:1995-08-01 00:00:00

  • Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms.

    abstract:BACKGROUND:Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy. Despite its efficacy, recurrences remain a common problem. METHODS:Patients with peritoneal dissemination from appendic...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21084

    authors: Bijelic L,Yan TD,Sugarbaker PH

    更新日期:2008-09-15 00:00:00

  • Development and validation of a risk stratification model for immediate microvascular breast reconstruction.

    abstract:BACKGROUND:Immediate breast reconstruction has many advantages but is associated with higher complication rates than delayed reconstruction. Complications can delay the delivery of adjuvant cancer treatments. This study aimed to develop and validate a risk stratification model for the prediction of perioperative compli...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25714

    authors: Roy M,Sebastiampillai S,Haykal S,Zhong T,Hofer SOP,O'Neill AC

    更新日期:2019-12-01 00:00:00

  • Increasing incidence and survival of a rare skin cancer in the Netherlands. A population-based study of 2,220 cases of skin adnexal carcinoma.

    abstract:BACKGROUNDS AND OBJECTIVES:The aim of this study was to describe the epidemiology and treatment of skin adnexal carcinoma (SAC) in the Netherlands and to identify prognostic factors for survival in patients with SAC. METHODS:We used population-based nationwide data from the Netherlands Cancer Registry with cases diagn...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23331

    authors: Stam H,Lohuis PJ,Zupan-Kajcovski B,Wouters MW,van der Hage JA,Visser O

    更新日期:2013-06-01 00:00:00

  • Sequential treatment for recurrent localized prostate cancer.

    abstract::To compare toxicity and efficacy of both salvage prostatectomy and salvage radiotherapy for prostate cancer a retrospective analysis was conducted. Thirty-two and 41 patients were treated with external beam radiotherapy or prostatectomy for cT1c-T2 prostate cancer later requiring salvage surgery or radiotherapy. Salva...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20967

    authors: Van Der Poel HG,Moonen L,Horenblas S

    更新日期:2008-04-01 00:00:00

  • Non-neurogenic soft tissue tumours of the axilla: prospective review of 16 cases.

    abstract::Sixteen consecutive patients entered in a prospective study of non-neurogenic soft tissue tumours had lesions in the axilla. Delayed diagnosis and inappropriate biopsy prior to referral to a surgical oncologist were frequent findings. Sarcoma and fibromatosis were diagnosed in 14 cases, and the approaches used for the...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930420203

    authors: Bell RS,Ready J,Hudson A,O'Sullivan B,Mahoney J,Richards R,Davis A,Fornasier VL

    更新日期:1989-10-01 00:00:00

  • Adjuvant Corynebacterium parvum immunotherapy for squamous cell epitheliomas of the oral cavity, pharynx, and larynx.

    abstract::Patients with primary squamous cell epitheliomas of the oral cavity, pharynx, and larynx were stratified according to stage and site and randomized to receive either intratumoral immunotherapy with Corynebacterium parvum followed 2 weeks later by surgery and postoperative C parvum for 2 years or surgery alone. There w...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jso.2930280215

    authors: Neifeld JP,Terz JJ,Kaplan AM,Lawrence W Jr

    更新日期:1985-02-01 00:00:00

  • Killing lung cancer cells at cell-cycle phase by a new indium-111-bleomycin complex.

    abstract::The efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2-M phase of the cell-cycle by a new 111In-bleomycin complex (111In-BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the ma...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930400203

    authors: Hou DY,Ordonez JV,Cross RJ,Ross DD,Maruyama Y

    更新日期:1989-02-01 00:00:00

  • Does age influence disease-specific survival in patients with squamous cell carcinomas of the head and neck?

    abstract:BACKGROUND AND OBJECTIVES:The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. METHODS:We performed a retrospective study of 5469 pati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25895

    authors: Lop J,Valero C,García J,Quer M,Ganly I,Shah JP,Patel SG,León X

    更新日期:2020-06-01 00:00:00

  • Creatine kinase isoenzyme (CK-BB) by RIA as a follow-up marker in stage D cancer of the prostate: comparison with PAP RIA.

    abstract::Fifty-nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK-BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK-BB as a follow-up marker com...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930280319

    authors: El-Shribiny A,Bharvaga A,Fitzpatrick J,Murphy GP

    更新日期:1985-03-01 00:00:00

  • Bacterial adherence to bladder tumors in the mouse.

    abstract::Mice with intravesical urothelial tumors (MBT-2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumor-bearing bladders than in normal non-tumor-bearing mice. The tumor-bearing portion of the bladder contai...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930230405

    authors: Bagley DH,Velanovich V,Jones KW,Heggers JP

    更新日期:1983-08-01 00:00:00

  • The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers.

    abstract:BACKGROUND AND OBJECTIVES:Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20426

    authors: Mimori K,Nagahara H,Sudo T,Ishii H,Yamashita K,Barnard GF,Mori M

    更新日期:2006-01-01 00:00:00

  • Malignant arterial tumor embolization.

    abstract::Malignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arterioscleroti...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930520317

    authors: Chandler C

    更新日期:1993-03-01 00:00:00

  • Preliminary report on surgical technique in hepatic parenchymal transection for liver tumors in the elderly: a lesson learned from living-related liver transplantation.

    abstract:BACKGROUND AND OBJECTIVES:Availability of hi-tech surgical devices has elaborated the technique of parenchymal transection during hepatectomy from classic crushing clamp technique 1,2 to a combination of an ultrasonic dissection with special type of cautery 3,4. We have developed a new technique to resect hepatic paren...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20154

    authors: Gruttadauria S,Doria C,Vitale CH,Cintorino D,Foglieni CS,Fung JJ,Marino IR

    更新日期:2004-12-15 00:00:00

  • Proton radiation therapy for head and neck cancer.

    abstract::Due to the close spatial relationship of head and neck and skull base tumors to numerous normal anatomical structures, conventional photon radiation therapy can be associated with significant acute and long-term treatment-related toxicities. Superior dose localization properties of proton radiation therapy allow small...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21013

    authors: Chan AW,Liebsch NJ

    更新日期:2008-06-15 00:00:00

  • Testicular cancer in young Norwegians.

    abstract::The clinical experience is reviewed in 597 Norwegian testicular cancer patients (age range: 15-45 years) treated from 1979 to 1986. During this period, computer tomography, determination of serum AFP/HCG, and cisplatin-based chemotherapy represented the modern diagnostic and therapeutic modalities. Before orchiectomy ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930390110

    authors: Fosså SD,Aass N,Kaalhus O

    更新日期:1988-09-01 00:00:00

  • Hepatic arterial cannulation using the side holed catheter.

    abstract:BACKGROUND:Hepatic arterial infusion chemotherapy (HAIC) has been recognized as one of the effective treatments for patients with hepatic metastatic tumor. However it is difficult to perform HAIC in the long term without complications. This report describes the laparotomic approach using the side holed catheter, which ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20283

    authors: Watanabe M,Takita W,Tsuchiya M,Otsuka Y,Tamura A,Kaneko H,Kobayashi K

    更新日期:2005-08-01 00:00:00

  • Lymphatic-venous anastomosis in a rat model: A novel exercise for microsurgical training.

    abstract:BACKGROUND AND OBJECTIVES:Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system. Lymphaticovenular anastomoses (LVA) and multiple lymphatic-venous anastomoses (MLVAs) have been recognized as efficient methods to treat chronic lymphedema. Because few models f...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25234

    authors: Leuzzi S,Maruccia M,Elia R,Annoscia P,Vestita M,Nacchiero E,Giudice G

    更新日期:2018-11-01 00:00:00

  • A novel preoperative risk score to predict lymph node positivity for rectal neuroendocrine tumors: An NCDB analysis to guide operative technique.

    abstract:BACKGROUND/OBJECTIVE:Staging and type of resection for rectal neuroendocrine tumors (R-NETS) relies on preoperative identification of lymph node (LN) involvement. Study objective was to develop a Preoperative Rectal Stratification Score (PReSS) for LN-positivity and to assess the association of PReSS with overall survi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25679

    authors: Gamboa AC,Liu Y,Lee RM,Zaidi MY,Staley CA,Russell MC,Cardona K,Sullivan PS,Maithel SK

    更新日期:2019-11-01 00:00:00

  • Predictors of costs associated with radical cystectomy for bladder cancer: A population-based retrospective cohort study in the province of Quebec, Canada.

    abstract:BACKGROUND AND OBJECTIVES:There is paucity of studies on the predictors of bladder cancer (BC) management costs. We aimed to determine predictors of costs associated with radical cystectomy (RC) for BC. METHODS:We conducted a retrospective analysis in a cohort of 2,759 patients who underwent RC for BC between 2000 and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24132

    authors: Santos F,Dragomir A,Zakaria AS,Kassouf W,Aprikian A

    更新日期:2016-02-01 00:00:00

  • Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses.

    abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930520415

    authors: Wile AG,Dileo SK,Gossett DA,Lao XY

    更新日期:1993-04-01 00:00:00

  • Outcome after reconstruction of proximal femoral tumors: A systematic review.

    abstract::Tumor resection followed by reconstruction with a proximal femoral endoprosthesis or an allograft-prosthesis composite are the two main alternatives for treatment of proximal femoral malignancies. This review describes the revision rate, implant survival, limb salvage rate, and function. Overall revision rates are hig...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1002/jso.25297

    authors: Janssen SJ,Langerhuizen DWG,Schwab JH,Bramer JAM

    更新日期:2019-01-01 00:00:00