Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma.

Abstract:

BACKGROUND AND OBJECTIVES:We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients. METHODS:One hundred and forty one cases of NPC and 25 normal tissues of nasopharynx were collected. The expression of MIF and interleukin 8 (IL-8) was evaluated in tissues microarray by immunostaining. Intratumoral microvessel density (IMD) in relation to immunostainings and clinicopathological factors were analyzed statistically as well as the follow-up data of patients. RESULTS:High-expression of both MIF (69.5%) and IL-8 (56.0%) were significantly associated with increased microvessels and lymph node metastasis. High-expression of MIF, IL-8 and higher level of IMD were correlated with either patients' overall survival or disease-specific survival in univariate analysis, but only angiogenesis and lymph node status exhibited in relation to survival of patients as independent prognostic factor of NPC by multivariate analysis. In addition, high-expression of MIF and higher level of IMD were closely associated with locoregional failure of NPC patients. CONCLUSIONS:MIF may contribute to lymph node metastasis in NPC by inducing angiogenesis through the way of upregulation of IL-8 expression in an autocrine EBV-independent pathway.

journal_name

J Surg Oncol

authors

Liao B,Zhong BL,Li Z,Tian XY,Li Y,Li B

doi

10.1002/jso.21728

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

844-51

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

102

pub_type

杂志文章
  • Preoperative chemoradiation and flap reconstruction provide high local control and low wound complication rates for patients undergoing limb salvage surgery for upper extremity tumors.

    abstract:BACKGROUND AND OBJECTIVES:Neoadjuvant protocols in the management of upper extremity sarcoma have improved local control rates but have been associated with high complication rates. We present a refinement of the Eilber protocol using judicious preoperative chemoradiation, limb salvage surgery, and flap coverage to ach...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20629

    authors: Temple CL,Ross DC,Magi E,DiFrancesco LM,Kurien E,Temple WJ

    更新日期:2007-02-01 00:00:00

  • Malignancy and differentiation of neoplastic epithelial cells of thymoma.

    abstract::Fifteen fetal thymuses and 100 thymomas were examined concerning the degree of differentiation of thymic epithelial cells by light and electron microscopy. The following results were obtained. The embryologic process of the fetal thymus was categorized into four stages (8, 12, 15, and 17 weeks or more of gestation) ba...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930310212

    authors: Monden Y,Tanioka T,Maeda M,Masaoka A,Nakahara K,Kawashima Y,Kitamura H

    更新日期:1986-02-01 00:00:00

  • Serum copper in carcinoma of cervix uteri as an indicator of successful radiotherapy.

    abstract::Serum copper levels (SCL) have been done in 106 patients of squamous cell carcinoma of the cervix and in 15 cases of local recurrences. The mean SCL has been significantly elevated in them in comparison to controls (P less than 0.001). The SCL falls to near normal range following successful therapy. There is a trend t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220313

    authors: Birdi A,Gupta S,Gambhir SS

    更新日期:1983-03-01 00:00:00

  • Methods of esophagogastric anastomoses following esophagectomy for cancer: A systematic review.

    abstract::Anastomotic complications are responsible for significant morbidity and mortality following esophagectomy for cancer. Conflicting reports exist regarding the superiority of hand-sewn versus stapled techniques. This systematic review identified eight randomized clinical trials examining this issue. None of the studies ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21510

    authors: Kim RH,Takabe K

    更新日期:2010-05-01 00:00:00

  • The prognostic significance of the insulin-like growth factor-1 ligand and receptor expression in breast cancer tissue.

    abstract:BACKGROUND AND OBJECTIVES:Previous in vitro studies have suggested that IGF-1 stimulation can lead a more aggressive breast cancers and subsequent poor prognosis in breast cancer patients. We aim to how IGF-1 and IGF-1R mRNA levels in breast cancer are associated with disease-free survival (DFS) and other clinicopathol...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21916

    authors: Chong KY,Subramanian A,Mokbel K,Sharma AK

    更新日期:2011-09-01 00:00:00

  • The peak-standardized uptake value (P-SUV) by preoperative positron emission tomography-computed tomography (PET-CT) is a useful indicator of lymph node metastasis in gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:Little data is currently available on the usefulness of peak-standardized uptake value (P-SUV) by positron emission tomography-computed tomography (PET-CT) in gastric cancer. The purpose of the present study was to evaluate the value of PET-CT for the preoperative evaluation of patients with g...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21985

    authors: Oh HH,Lee SE,Choi IS,Choi WJ,Yoon DS,Min HS,Ra YM,Moon JI,Kang YH

    更新日期:2011-10-01 00:00:00

  • Outcomes in operative management of pancreatic cancer.

    abstract::Pancreatic cancer is a highly lethal malignancy that often presents at an advanced stage. Surgical resection can prolong survival and offers the only potential for cure. However, pancreatectomy is associated with significant morbidity and mortality. This article reviews perioperative outcomes, post-resection long-term...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23744

    authors: Bliss LA,Witkowski ER,Yang CJ,Tseng JF

    更新日期:2014-10-01 00:00:00

  • DNA ploidy and PCNA index in pancreatic lesions producing hyperinsulinemic hypoglycemia.

    abstract::DNA nuclear content and PCNA index (proportion of PCNA reactive cells) have been studied by flow cytometry in eight pancreatic lesions producing hyperinsulinemic hypoglycemia to assess DNA ploidy and tumoral growth fraction. Adult nesidioblastosis had a diploid DNA index, two adenomas were near diploid, and four of th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930590105

    authors: Losada J,Sarria R,Fernandez Val JF,Lopez Ariztegui MA

    更新日期:1995-05-01 00:00:00

  • Treatment of metastatic melanoma with electrochemotherapy.

    abstract::Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low‐toxicity anticancer drug, can be a valuable trea...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23512

    authors: Campana LG,Testori A,Mozzillo N,Rossi CR

    更新日期:2014-03-01 00:00:00

  • Application of the immunoperoxidase method for rapid intraoperative pathological diagnosis of pancreatic cancer.

    abstract::Intrapancreatic extension of pancreatic duct cell carcinoma in 19 resectable cases was evaluated by both hematoxylin and eosin (H&E) staining and quick immunostaining using antibodies against cancer-associated antigens--e.g., CA19-9, DUPAN 2, and CEA--on the intraoperative frozen-section biopsy during the course of la...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930400105

    authors: Ichihara T,Nakao A,Sakamoto J,Nonami T,Harada A,Watanabe T,Takagi H,Nagura H

    更新日期:1989-01-01 00:00:00

  • Extrahepatic metastasectomy for hepatocellular carcinoma: Predictors of long-term survival.

    abstract:INTRODUCTION:We report our institutional experience with extrahepatic metastasectomy (EM) in a cohort of hepatocellular carcinoma (HCC) patients with focus on predictors of survival. METHODS:All patients diagnosed with metastatic HCC from 2001 to 2014 were retrospectively reviewed to identify those who underwent EM wi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24340

    authors: Berger Y,Spivack JH,Heskel M,Aycart SN,Labow DM,Sarpel U

    更新日期:2016-09-01 00:00:00

  • Phase II study of a modified combination of etoposide, doxorubicin, and cisplatin for patients with advanced gastric cancer.

    abstract:BACKGROUND:Based on the promising results of EAP (etoposide, doxorubicin, and cisplatin) combination, a phase II study of modified EAP combination was performed in patients with advanced gastric cancer to evaluate the response, toxicity, and survival. METHOD:Fifty-two consecutive patients with measurable or evaluable ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1096-9098(199704)64:4<318::aid-jso13

    authors: Içli F,Karaoguz H,Akbulut H,Dinçol D,Demirkazik A,Cay F

    更新日期:1997-04-01 00:00:00

  • Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma.

    abstract:INTRODUCTION:Isolated limb infusion (ILI) is a minimally invasive alternative to isolated limb perfusion (ILP) for delivering high-dose regional chemotherapy to treat locally advanced limb melanoma. The current study aimed to evaluate the applicability of ILI in four Australian tertiary referral centers outside of its ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.23590

    authors: Coventry BJ,Kroon HM,Giles MH,Henderson M,Speakman D,Wall M,Barbour A,Serpell J,Paddle P,Coventry AG,Sullivan T,Smithers BM

    更新日期:2014-06-01 00:00:00

  • Breast implant-associated anaplastic large cell lymphoma, a systematic review and in-depth evaluation of the current understanding.

    abstract::Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a T-cell neoplasm that arises in the capsule around breast implants. While an association with implants has been proposed, no causal link has been identified and the pathophysiology and natural history of BIA-ALCL remain unknown. A literature revie...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25626

    authors: Ebner PJ,Liu A,Gould DJ,Patel KM

    更新日期:2019-09-01 00:00:00

  • Whole liver intraoperative irradiation after partial hepatectomy produces minimal functional and pathologic lesions.

    abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930500205

    authors: Bellantone R,Bossola M,Merrick HW,Doglietto GB,Ratto C,Minimo C,Crucitti A,Valentini V,Morganti A,Cellini N

    更新日期:1992-06-01 00:00:00

  • Growth index, assessed with Ki-67 and ssDNA labeling; a significant prognosticator for patients undergoing curative resection for hepatocellular carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20309

    authors: Morinaga S,Ishiwa N,Noguchi Y,Yamamoto Y,Rino Y,Imada T,Takanashi Y,Akaike M,Sugimasa Y,Takemiya S

    更新日期:2005-12-15 00:00:00

  • Significant prolongation of segmental pancreatic allograft survival in two species.

    abstract::A study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL 1 in combination with CSA in baboons. Total pancreatectomy in the dog and primate provided a reliable diabetic model, induced a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930380217

    authors: Du Toit DF,Heydenrych JJ

    更新日期:1988-06-01 00:00:00

  • Comparative analysis of imaging modalities in the preoperative assessment of nodal metastasis in esophageal cancer.

    abstract::Preoperative radiological findings of nodal status in 74 patients, using endoscopic ultrasonography (EUS), computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI), were compared to histopathology reports following transthoracic total esophagectomy with radical lymphadenectomy (TTE), involv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10

    authors: Chandawarkar RY,Kakegawa T,Fujita H,Yamana H,Hayabuthi N

    更新日期:1996-03-01 00:00:00

  • Verrucous carcinoma of the foot.

    abstract::A 50-year-old man presented with verrucous carcinoma on the sole of the foot. This unusual tumor, also called an epithelioma cuniculatum plantare, was successfully treated employing wide surgical excision. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930140407

    authors: Schwartz RA,Burgess GH

    更新日期:1980-01-01 00:00:00

  • Preoperative positivity of serum tumor markers is a strong predictor of hematogenous recurrence of gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:Preoperative positivity of serum tumor markers has been reported to be a prognostic factor in several neoplasms. The aim of this longitudinal study was to evaluate the correlation between CEA, CA 19-9, and CA 72-4 preoperative serum levels and the site of recurrence after curative surgery for ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1163

    authors: Marrelli D,Pinto E,De Stefano A,de Manzoni G,Farnetani M,Garosi L,Roviello F

    更新日期:2001-12-01 00:00:00

  • Cryoablation and cryolocalization in the management of breast disease.

    abstract::Cryotechnology is currently used for both treatment and diagnosis of breast disease. Due to the natural analgesic effect of cold, cryoablation is potentially more patient-friendly than other technologies which raise tissue temperature. Freezing produces a predictable volume of necrosis and is easily observed and contr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.20201

    authors: Whitworth PW,Rewcastle JC

    更新日期:2005-04-01 00:00:00

  • Surgery promotes implantation of disseminated tumor cells, but does not increase growth of tumor cell clusters.

    abstract:INTRODUCTION:Local recurrence and peritoneal dissemination is common after intentionally curative resection of colorectal carcinoma. It is not yet clear which mechanisms stimulate post-operative intra-abdominal tumor development. Enhanced adhesion or growth of tumor cells and/or post-operative immuno suppression may in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20273

    authors: Raa ST,Oosterling SJ,van der Kaaij NP,van den Tol MP,Beelen RH,Meijer S,van Eijck CH,van der Sijp JR,van Egmond M,Jeekel J

    更新日期:2005-11-01 00:00:00

  • Alpha-fetoprotein and carcinoembryonic antigen in pancreatobiliary disease with and without jaundice.

    abstract::A comparative study of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in serum was made by radioimmunoassay in 66 patients with pancreatobiliary disease with and without obstructive jaundice. biliary concentrations of these proteins were assayed in 12 patients with benign and 7 patients with malignant dise...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930190411

    authors: Satake K,Cho K,Umeyama K

    更新日期:1982-04-01 00:00:00

  • Renal cell carcinoma in a horseshoe kidney.

    abstract::A case of renal cell carcinoma arising in a horseshoe kidney and presenting with a pathologic fracture of humerus is reported. Relevant literature is discussed. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930260116

    authors: Wiener M,Sarma D,Rao M

    更新日期:1984-05-01 00:00:00

  • The rabbit as an experimental animal for tracheal surgery.

    abstract::The circumferential resection of the trachea with end-to-end anastomosis is a well-established clinical procedure. Still, some problems remain to be solved, such as the choice of optimal suture material. Dogs are primarily used for experimental work in this field, but are difficult to obtain. This operation was perfor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930370114

    authors: Peleg H,Rao UN,Emrich LJ

    更新日期:1988-01-01 00:00:00

  • Clinicopathologic characteristics and prognostic significance of EGFR and p53 mutations in surgically resected lung adenocarcinomas ≤2 cm in maximal dimension.

    abstract:BACKGROUND AND OBJECTIVES:Small lung adenocarcinomas are detected more frequently than in the past. However, the clinicopathologic characteristics and prognostic significance of EGFR/p53 mutations in these tumors remains unclear. METHODS:We evaluated the correlation of EGFR/p53 mutations with clinicopathologic charact...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23628

    authors: Lin MW,Wu CT,Shih JY,Chang YL,Yang PC

    更新日期:2014-08-01 00:00:00

  • Epiphyseal fractures in children treated for osteosarcoma of the femur with chemotherapy, tumourresection, and endoprosthesis: report of four fractures in two children.

    abstract::This paper reports on two patients, who both were under treatment for osteosarcoma of the femur. Treatment consisted of chemotherapy, resection of the tumour, and reconstruction with an endoprosthesis . Both patients sustained an epiphyseal fracture on two occasions after a minor trauma. Careful observations of the x-...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930260110

    authors: Veth RP,De Graaf SS,Den Heeten GJ,Oldhoff J,Hoekstra HJ,Schraffordt Koops H,Nielsen HK

    更新日期:1984-05-01 00:00:00

  • Primary carcinoma of the gallbladder in Taiwan.

    abstract::To define more precisely the prognostic index for patients with primary carcinoma of the gallbladder in Taiwan, we retrospectively reviewed the data of 74 patients with gallbladder carcinoma treated over a period of 15 years, from 1979 to 1993. Of these patients, 75% had Nevin stage V gallbladder cancer. The most comm...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199601)61:1<49::AID-JSO11>

    authors: Chao TC,Wang CS,Jeng LB,Jan YY,Chen MF

    更新日期:1996-01-01 00:00:00

  • Lymph node regression after neoadjuvant chemotherapy: A predictor of survival in gastric cancer.

    abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25785

    authors: Pereira MA,Ramos MFKP,Dias AR,Cardili L,Ribeiro RRE,Charruf AZ,de Castria TB,Zilberstein B,Ceconello I,Avancini Ferreira Alves V,Ribeiro U Jr,de Mello ES

    更新日期:2020-04-01 00:00:00

  • Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients.

    abstract:INTRODUCTION:Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the valu...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20297

    authors: Takkenberg RB,Vrouenraets BC,van Geel AN,Nieweg OE,Noorda EM,Eggermont AM,Kroon BB

    更新日期:2005-08-01 00:00:00