Emerging lethal infectious bronchitis coronavirus variants with multiorgan tropism.

Abstract:

:Infectious bronchitis virus (IBV) causes respiratory diseases in chickens and poses an economic threat to the poultry industry worldwide. Despite vaccine use, there have been field outbreaks of IBV in Taiwan. This study aimed to characterize the emerging IBV variants circulating in Taiwan. The analysis of the structural protein genes showed that these variants emerged through frequent recombination events among Taiwan strains, China strains, Japan strains and vaccine strains. Cross-neutralization tests revealed that two of the variants exhibited novel serotypes. Clinicopathological assessment showed that two of the variants caused high fatality rates of 67% and 20% in one-day-old SPF chicks, and all the variants possessed multiorgan tropisms, including trachea, proventriculus and urogenital tissues. Furthermore, the commercial live-attenuated Mass-type vaccine conferred poor protection against these variants. This study identified novel genotypes, serotypes and pathotypes of emerging IBV variants circulating in Taiwan. There is an urgent need for effective countermeasures against these variant strains.

journal_name

Transbound Emerg Dis

authors

Li YT,Chen TC,Lin SY,Mase M,Murakami S,Horimoto T,Chen HW

doi

10.1111/tbed.13412

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

884-893

issue

2

eissn

1865-1674

issn

1865-1682

journal_volume

67

pub_type

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