Inter-serotype reassortment among epizootic haemorrhagic disease viruses in the United States.

Abstract:

:First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double-stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year.

journal_name

Transbound Emerg Dis

authors

Wang L,Lanka S,Cassout D,Mateus-Pinilla NE,Li G,Wilson WC,Yoo D,Shelton P,Fredrickson RL

doi

10.1111/tbed.13257

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1809-1820

issue

5

eissn

1865-1674

issn

1865-1682

journal_volume

66

pub_type

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