Abstract：
:An allosteric mechanism refers to the biological regulation process wherein macromolecules propagate the effect of ligand binding at one site to a spatially distant orthosteric locus, thus affecting activity. The theory has remained a trending topic in biology research for over 50 years, since the understanding of allostery is fundamental for gleaning numerous biological processes and developing new drug therapies. In the past two decades, the allosteric paradigm has evolved into more descriptive models, with ever-expanding amounts of experimental data pertaining to newly identified allosteric molecules. The AlloSteric Database (ASD, accessible at http://mdl.shsmu.edu.cn/ASD ), which is a comprehensive knowledge repository, has provided the public with integrated information encompassing allosteric proteins, modulators, sites, pathways, and networks to investigate allostery since 2009. In this chapter, we introduce the history and usage of the ASD and give attention to specific applications that have benefited from the ASD.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Song K,Zhang J,Lu Sdoi
10.1007/978-981-13-8719-7_4subject
Has Abstractpub_date
2019-01-01 00:00:00pages
65-87eissn
0065-2598issn
2214-8019journal_volume
1163pub_type
杂志文章,评审abstract：:Kinins are potent myotropic agents acting on a variety of smooth muscle preparations: isolated arteries, veins, intestines, tracheae, urinary bladders, uteri, etc. In these tissues, kinins activate at least two different receptor types, B1 and B2. B1 and B2 receptors for kinins have been identified by measuring the or...
journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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doi：10.1007/978-1-4615-1371-1_34
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pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/978-3-319-53889-1_13
更新日期：2017-01-01 00:00:00
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doi：10.1007/978-1-4614-0332-6_2
更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/978-3-030-15950-4_22
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
abstract：:The full length spike (S) gene of porcine respiratory coronavirus (PRCV) was inserted into the genome of human adenovirus type 5 downstream of the early transcription region 3 promoter. The recombinant virus replicated in cultures of the swine testicle ST cell line and directed the synthesis of S antigen to an amount ...
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