Abstract:
:Obstructive sleep apnea (OSA) is a common respiratory disorder associated with hypertension and cardiovascular complications. Blood pressure variability may be a sign of risk of cardiovascular events. The aim of this study was to investigate the hypothesis that severe OSA syndrome is associated with increased blood pressure variability. Based on respiratory polygraphy, 58 patients were categorized into two groups: severe OSA with apnea/hypopnea index (AHI) greater than 29 episodes per hour (mean 52.2 ± 19.0/h) and mild-to-moderate OSA with AHI between 5 and 30 episodes per hour (mean 20.2 ± 7.8/h). A 24-h noninvasive blood pressure monitoring was performed. The standard deviation of mean blood pressure was used as the indicator of blood pressure variability. In patients with severe, compared with mild-to-moderate OSA, a higher mean nocturnal systolic blood pressure (133.2 ± 17.4 mmHg vs. 117.7 ± 31.2 mmHg, p < 0.05) and diastolic blood pressure (80.9 ± 13.1 mmHg vs. 73.8 ± 9.2, p < 0.01), nocturnal systolic blood pressure variability (12.1 ± 6.0 vs. 7.6 ± 4.3, p < 0.01) and diastolic blood pressure variability (10.5 ± 6.1 vs. 7.3 ± 4.0 p < 0.05), nocturnal mean blood pressure variability (9.1 ± 4.9 mmHg vs. 6.8 ± 3.5 mmHg) were detected. The findings of the study point to increased nocturnal systolic and diastolic arterial blood pressure and blood pressure variability as risk factors of cardiovascular complications in patients with severe OSA.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Martynowicz H,Porębska I,Poręba R,Mazur G,Brzecka Adoi
10.1007/5584_2016_64subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9-15eissn
0065-2598issn
2214-8019journal_volume
952pub_type
杂志文章abstract::Loss of the control over cellular proliferation can lead to cell death or result in the abnormal proliferation characteristic of the cancerous state. Among the controls used to achieve normal cellular proliferation is the DNA damage checkpoint pathway that monitors genome integrity (Hartwell and Kastan 1994). 53BP1 wa...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-0-387-69116-9_3
更新日期:2007-01-01 00:00:00
abstract::Bronchitis is a common health problem in children. Frequent bronchitis in infancy increases the risk of developing chronic respiratory diseases. The aim of the study was to assess the level of growth and the nutritional status in children and youths with special regard to the level of body fatness assessed by measurin...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/5584_2015_192
更新日期:2016-01-01 00:00:00
abstract::Stargardt disease (STGD) is one of the most common macular dystrophies in young adults. It progresses slowly. Its prevalence is about 1:8000-10,000. Age of onset is a surrogate marker: The earlier the onset, the more severe the disease course. Onset usually occurs in childhood or early adolescence, at about 10-15 year...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-95046-4_27
更新日期:2018-01-01 00:00:00
abstract::The availability of numerical data grows from 1 day to another in a remarkable way. New technologies of high-throughput Next-Generation Sequencing (NGS) are producing DNA sequences. Next-Generation Sequencing describes a DNA sequencing technology which has revolutionized genomic research. In this paper, we perform som...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-030-32622-7_42
更新日期:2020-01-01 00:00:00
abstract::Cyanobacteria become increasingly dominant as concentrations of TP and TN increase during eutrophication of lakes, rivers and estuaries. Temporal dynamics of cyanobacteria blooms are variable--in some systems persistent blooms occur in summer to fall, whereas in other systems blooms are more sporadic. Cyanobacteria bl...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-0-387-75865-7_33
更新日期:2008-01-01 00:00:00
abstract::The P300 event-related potential (ERP) is associated with attention and memory operations of the brain. P300 is changed in many cognitive disorders such as dementia, Alzheimer, schizophrenia, and major depression disorder. Therefore, investigation on basis of this component can help to improve our understanding of pat...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4419-7046-6_60
更新日期:2011-01-01 00:00:00
abstract::The complexity of modern biological database management systems indicates the need of integrated metadata repositories for harmonized and high-quality assured data processing. Such systems should allow for the derivation of specific producer-oriented indicators monitoring the quality of the final datasets and statisti...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4419-5913-3_11
更新日期:2010-01-01 00:00:00
abstract::Muscle force arises as the result of many myosin molecules, each producing a force discrete in magnitude and in time duration. In previous work we have developed a computer model and a mathematical model of many myosin molecules acting as an ensemble and demonstrated that the time duration over which myosin produces f...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4419-6366-6_4
更新日期:2010-01-01 00:00:00
abstract::The origin of DNA replication of bacteriophage f1 consists of two functional domains: 1) a "core region", about 40 nucleotides long, that is absolutely required for viral (plus) strand replication and contains three distinct but partially overlapping signals, a) the recognition sequence for the viral gene II protein, ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-8730-5_18
更新日期:1984-01-01 00:00:00
abstract::While clinical guidelines clearly define mechanisms for asthma diagnosis based upon history, lung function testing, symptoms, and physical examination, surveillance for asthma is much less straightforward. Epidemiologists have long debated the best means of assessing the scope and burden of asthma, seeking to reduce t...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4614-8603-9_2
更新日期:2014-01-01 00:00:00
abstract::Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for the same cullin core, the assembly and activity of CRLs ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-981-15-1025-0_3
更新日期:2020-01-01 00:00:00
abstract::Digenetic trematodes form a major group of human parasites, affecting a large number of humans, especially in endemic foci. Over 100 species have been reported infecting humans, including blood, lung, liver, and intestinal parasites. Traditionally, trematode infections have been diagnosed by parasitological methods ba...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-030-18616-6_14
更新日期:2019-01-01 00:00:00
abstract::Jørgensen and Dau (J Acoust Soc Am 130:1475-1487, 2011) proposed the speech-based envelope power spectrum model (sEPSM) in an attempt to overcome the limitations of the classical speech transmission index (STI) and speech intelligibility index (SII) in conditions with nonlinearly processed speech. Instead of consideri...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4614-1590-9_38
更新日期:2013-01-01 00:00:00
abstract::Neuregulins, members of the largest subclass of growth factors of the epidermal growth factor family, mediate a myriad of cellular functions including survival, proliferation, and differentiation in normal tissues through binding to receptor tyrosine kinases of the ErbB family. However, aberrant neuregulin signaling i...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-030-47189-7_1
更新日期:2021-01-01 00:00:00
abstract::Epigenetic memories are acquired information included in the chromatin or DNA such as methylation and histone modifications. Recent studies suggest that epigenetic memories determine the types of differentiated cells in each tissue. Moreover, the development of metabolic diseases induced by environmental factors durin...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-981-10-5526-3_2
更新日期:2018-01-01 00:00:00
abstract::It is well established that muscle fatigue, defined as a decline in maximal force generating capacity, is a common response to muscular activity. To what extent metabolic factors contribute to the reduced muscle function is still debated. Metabolic effects can affect muscle through different processes, either through ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4899-1016-5_15
更新日期:1995-01-01 00:00:00
abstract::In contrast to heavily methylated mammalian genomes, invertebrate genomes are only sparsely methylated in a 'mosaic' fashion with the majority of methylated CpG dinucleotides found across gene bodies. Importantly, this gene body methylation is frequently associated with active transcription, and studies in the honeybe...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-43624-1_9
更新日期:2016-01-01 00:00:00
abstract::We have previously reported changes in the concentrations of oxy-(delta[HbO2]) deoxy- (delta[HHb]) and total haemoglobin (delta[HbT] = delta[HbO2] + delta[HHb]) measured using near infrared spectroscopy (NIRS) over the frontal cortex (FC) during an anagram solving task. These changes were associated with a significant...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-0-387-74911-2_3
更新日期:2008-01-01 00:00:00
abstract::Stimulator of interferon (IFN) genes (STING) is a key mediator in the immune response to cytoplasmic DNA sensed by cyclic GMP-AMP (cGAMP) synthase (cGAS). After synthesis by cGAS, cGAMP acts as a second messenger activating STING in the cell harboring cytoplasmic DNA but also in adjacent cells through gap junction tra...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-981-10-5987-2_8
更新日期:2017-01-01 00:00:00
abstract::The relation of transcutaneous pO2 (tcpO2) and cutaneous blood flow (CBF) was measured on the forearm of 19 healthy volunteers by use of a tcpO2 electrode heated to 45 degrees C. CBF was estimated indirectly from the heating power of the electrode (HP) and with a 8 MHz bidirectional ultrasonic probe by Doppler shift i...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4613-1927-6_48
更新日期:1987-01-01 00:00:00
abstract::In mammals, parental care is essential for the survival of the young; therefore, it is vitally important to the propagation of the species. These behaviors, differing between the two sexes, are innate, stereotyped, and are also modified by an individual's reproductive experience. These characteristics suggest that neu...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-981-15-7086-5_6
更新日期:2020-01-01 00:00:00
abstract::In summary, it can be said that in spite of possible limitations, this technique provides previously unattainable data on capillary flow pattern in the myocardium. Qualitative and quantitative results indicate that the following anatomical and physiological concepts should be incorporated in any further modelling of o...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-9510-6_53
更新日期:1988-01-01 00:00:00
abstract::It is clear that the combination of 31P NMR studies of muscle and of other organs with biochemical and physiological measurements is an extremely powerful method for studying cellular energetics. We have presented examples of our on-going experiments. Well defined and stable in vitro preparations of mammalian fast-twi...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-7790-0_27
更新日期:1983-01-01 00:00:00
abstract::Chronic inflammatory diseases of the intestine (i.e. Crohn's and chronic ulcerative colitis- collectively known as inflammatory bowel disease [IBD]) are a very significant public health problem in the United States and other industrialized nations. Thus, effort has been made toward understanding the biological mechani...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4615-0193-0_35
更新日期:2002-01-01 00:00:00
abstract::MP4CO, developed by Sangart Inc. (San Diego, CA), is a pegylated human hemoglobin-based carbon monoxide (CO) delivery agent and oxygen therapeutic that has shown potential to prevent and reverse red cell sickling. A double blind, comparator controlled, dose-escalation, Phase 1b study was conducted to assess the safety...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/978-3-319-38810-6_3
更新日期:2016-01-01 00:00:00
abstract::Sarcoidosis is a systemic granulomatous disease with unknown etiology. Lungs and lymph nodes are commonly affected. Also, cases of pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are described. However, the exact prevalence of PAH in patients with sarcoidosis is unclear. A 111 patients with prove...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-94-007-4546-9_38
更新日期:2013-01-01 00:00:00
abstract::Although a time-resolved near-infrared spectroscopy (TRS) system is difficult to make a measurement into 10 s or less at the moment, the system has a great advantage that it measures absolute values of hemoglobin concentrations. In the present study, using a device equipped with a TRS system, we examined individual di...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4419-1241-1_36
更新日期:2010-01-01 00:00:00
abstract::The ability to serially collect blood samples and conduct ultrasound examinations in Asian and African elephants has provided unique opportunities to study the biology of these endangered species. As a result, many unique aspects of elephant reproduction have been identified. For females, there are interesting differe...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4939-0820-2_8
更新日期:2014-01-01 00:00:00
abstract::The chemical reactions of the amino group of taurine with aldehydes were investigated. Glucose, acetaldehyde, and malondialdehyde were used as aldehydes. After taurine had reacted, the amounts of remaining taurine and aldehydes were measured, and the reactivity was evaluated. Amino acids such as glycine, alpha-alanine...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4899-1471-2_8
更新日期:1994-01-01 00:00:00
abstract::Aqueous dispersions of pure gangliosides contain micelles of these compounds. In this dispersion state, the rates of hydrolysis of the neuraminyl residues by bacterial neuraminidases are slowest. Incorporation of gangliosides into mixed dispersion with other lipids or into mixed micelles with bile salts considerably i...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-7844-0_13
更新日期:1980-01-01 00:00:00