Abstract:
OBJECTIVE:To investigate costs and quality-adjusted life years of rehabilitation combined with abobotulinumtoxinA (aboBoNT-A) (rehab/aboBoNT-A) vs rehabilitation alone (rehab) in post-stroke spasticity in Italy. DESIGN:Based on both Italian National Health Service and societal perspectives, a 2-year cost-utility analysis model was performed. Subject/patients: The cost-utility analysis model considered hypothetical patients. METHODS:The cost-utility analysis model was populated with data concerning demographics, disease severity, healthcare and non-healthcare resource consumption. Data were collected via a questionnaire administered to 3 highly experienced Italian physiatrists (864 out of 930 post-stroke spasticity patients on rehab/aboBoNT-A in total). Costs are expressed in Euro (€) based on the year 2018. RESULTS:The cost to society (rounded to the nearest whole €) was €22,959 (rehab/aboBoNT-A) vs €11,866 (rehab). Italian National Health Service-funded cost was €7,593 (rehab/aboBoNT-A) vs €1,793 (rehab). Over a period of 2 years rehab/aboBoNT-A outperforms rehab in terms of quality-adjusted life years gained (1.620 vs 1.150). The incremental cost-utility ratio was €12,341 (Italian National Health Service viewpoint) and €23,601 (societal viewpoint). Sensitivity analyses confirmed the robustness of the baseline results. CONCLUSION:Despite some limitations, the higher number of quality-adjusted life years gained vs rehab and the high probability of reaching a cost-utility ratio lower than the Italian informal acceptability range (€25,000-40,000) make rehab/aboBoNT-A a cost-effective healthcare programme for treating patients with post-stroke spasticity in Italy.
journal_name
J Rehabil Medjournal_title
Journal of rehabilitation medicineauthors
Lazzaro C,Baricich A,Picelli A,Caglioni PM,Ratti M,Santamato Adoi
10.2340/16501977-2636subject
Has Abstractpub_date
2020-02-07 00:00:00issue
2eissn
1650-1977issn
1651-2081journal_volume
52pub_type
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journal_title:Journal of rehabilitation medicine
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journal_title:Journal of rehabilitation medicine
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更新日期:2015-04-01 00:00:00
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更新日期:2018-11-07 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of rehabilitation medicine
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更新日期:2009-05-01 00:00:00
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doi:10.2340/16501977-2294
更新日期:2018-04-18 00:00:00
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of rehabilitation medicine
pub_type: 历史文章,杂志文章
doi:10.2340/16501977-0239
更新日期:2008-10-01 00:00:00
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更新日期:2009-11-01 00:00:00
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doi:10.2340/16501977-0160
更新日期:2008-04-01 00:00:00
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journal_title:Journal of rehabilitation medicine
pub_type: 信件
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更新日期:2016-04-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2005-05-01 00:00:00