Cytogenetic studies in couples with recurrent pregnancy loss.

Abstract:

:We reviewed the results of lymphocyte karyotypes from 232 couples who had had two or more pregnancy losses (spontaneous abortions or stillbirths). Despite the use of strict criteria to correct for possible bias of ascertainment, 8% of these couples (19 of 232) had a chromosome abnormality. Six of these abnormalities were low-percentage mosaicism for aneuploidy or a translocation. If these couples were excluded, 13 (6%) of the study couples had a chromosome abnormality. There was no significant difference in the incidence of chromosome abnormalities in those couples having two losses as compared with those having three or more losses. The study couples were referred from a wide range of sources, and most women had not had extensive gynecologic evaluation. These results confirm the importance of cytogenetic analysis of couples with recurrent pregnancy loss, and suggest that such studies be considered after two losses.

journal_name

South Med J

journal_title

Southern medical journal

authors

Sider D,Wilson WG,Sudduth K,Atkin JF,Kelly TE

doi

10.1097/00007611-198812000-00014

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

1521-4

issue

12

eissn

0038-4348

issn

1541-8243

journal_volume

81

pub_type

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