Carbamazepine therapy in neuropsychiatric patients.

Abstract:

:We reviewed the charts of 106 patients treated with carbamazepine. Age, sex, race, seizure type, seizure focus, age at onset, duration of epileptic illness, reasons for discontinuing treatment, other medications, and response to treatment of seizures, psychiatric symptoms, and behavioral symptoms were recorded. Statistical analysis was done to determine clinical factors influencing response to carbamazepine. Increasing duration of epileptic illness leads to a decreased response to carbamazepine, which controls both seizure and behavioral symptoms effectively; concurrent medication decreases behavioral symptom control without affecting the control of the seizures. We found a strongly negative correlation between duration of seizures and improvement of psychiatric symptoms with carbamazepine therapy. We provide a clinical profile of the carbamazepine responder to guide clinicians in their use of this drug.

journal_name

South Med J

journal_title

Southern medical journal

authors

Burns RL,Jenkins PL,Vallini AD

doi

10.1097/00007611-199301000-00005

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

23-6

issue

1

eissn

0038-4348

issn

1541-8243

journal_volume

86

pub_type

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