Distal renal tubular acidosis in selective hypoaldosteronism.

Abstract:

:Renal mechanisms for metabolic acidosis in selective hypoaldosteronism were investigated in a patient with marked renal insufficiency. Studies demonstrated a distal hydrogen ion secretory defect. Control of elevated serum potassium levels did not normalize urinary acid excretion, but systemic acidosis was improved. Mineralocorticoid therapy normalized serum potassium without increasing urinary potassium. Hyperkalemia did not directly affect renal acid handling, and extrarenal mechanisms for potassium excretion are suggested. Measurement of rectal mucosal potential difference suggests this test may be of value in detecting a wide range of abnormalities in aldosterone metabolism.

journal_name

South Med J

journal_title

Southern medical journal

authors

Barbour GL,Keller AW Jr

doi

10.1097/00007611-197811000-00023

subject

Has Abstract

pub_date

1978-11-01 00:00:00

pages

1397-400

issue

11

eissn

0038-4348

issn

1541-8243

journal_volume

71

pub_type

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