Abstract:
OBJECTIVES:Helicobacter pylori is prevalent worldwide, especially in Latin America. Triple and quadruple antibiotic therapies have been relatively effective; however, resistance has emerged in recent years. The treatment success rate of these regimens on the border of the United States and Mexico is unknown. Our study attempted to determine eradication rates of two major regimens based on urea breath test (UBT) results in patients previously diagnosed as having H. pylori in a single center in El Paso, Texas, a city on the geographic border with Mexico. METHODS:This was a retrospective cohort study of adult patients with H. pylori who underwent UBT after being treated with triple therapy (amoxicillin/clarithromycin/proton pump inhibitor for 14 days), quadruple therapy (tetracycline/metronidazole/bismuth/proton pump inhibitor, usually for 10 days), or both for H. pylori from 2010 to 2015 in a county hospital. Patients were excluded if they did not complete therapy or if their treatment regimen was unknown. The Student t test and the χ2 test were used to analyze the data. The cumulative incidence and 95% confidence interval (CI) for treatment success were estimated. RESULTS:A total of 104 patients completed the treatment for H. pylori and had UBT. Mean age was 53 years, 76% were women, 85% were Hispanic, and mean body mass index was 30.5 kg/m2. Of the 104 patients diagnosed as having H. pylori, 88 received triple therapy (84.6%) and 16 received quadruple therapy: 12 (11.5%) standard quadruple therapy, 4 (3.9%) triple therapy plus metronidazole. There were no differences between groups regarding age, sex, body mass index, or ethnicity. Overall, 90 (86.5%, 95% CI 78-92) patients had negative UBT after initial treatment. Based on posttreatment UBT, the triple therapy group had a similar eradication rate compared with the quadruple therapy group (78/88, 88.6% vs 12/16, 75.0%, P = 0.22). Of the 14 patients with positive posttreatment UBT, 12 (85.7%) received retreatment (2 were lost to follow-up), 11 (91.7%) received quadruple therapy, and 1 (8.3%) received triple therapy. Eradication was successful in 9 of 12 (75%, 95% CI 43-95) patients at retreatment. As such, of the initial 104 patients, 99/104 (95.2%) achieved H. pylori eradication posttreatment (either initial or retreatment). CONCLUSIONS:In a predominantly Hispanic population on the US-Mexico border, H. pylori eradication rates based on UBT results were relatively high and were similar for triple therapy and quadruple therapy. Quadruple therapy was effective for those who failed the initial H. pylori treatment. This may have implications for cost-effective therapy in our region.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Liu RP,Romero R,Sarosiek J,Dodoo C,Dwivedi AK,Zuckerman MJdoi
10.14423/SMJ.0000000000000747subject
Has Abstractpub_date
2018-01-01 00:00:00pages
51-55issue
1eissn
0038-4348issn
1541-8243pii
SMJ50477journal_volume
111pub_type
杂志文章abstract::Each year about 1.5 million people suffer from a traumatic brain injury. Many of these are seen in primary care settings and most recover completely. Traumatic brain injury can show many signs and symptoms, some of which are readily identified and treated. Often the neurobehavioral sequelae appear months to years late...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e3181aba321
更新日期:2009-08-01 00:00:00
abstract::An unusual intestinal infection with the parasite Metagonimus yokogawai was acquired by an American traveling in the Orient. Diarrhea began abroad, and recurred at intervals until she was seen 1 1/2 years later. Stool examinations resulted in the recovery of small operculated ova characteristic of intestinal or biliar...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197812000-00020
更新日期:1978-12-01 00:00:00
abstract::When involuntary psychiatric patients are treated on unlocked units, problems may arise as to resource expenditure and the ability to provide optimal psychiatric care. This study investigates the problem and possible solutions. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199306000-00016
更新日期:1993-06-01 00:00:00
abstract::Two cases of recurrent psychotic depression are reported in which ECT (electroconvulsive therapy) was administered with good results for previous episodes of depression, but treatment of the current episode with combined drug therapy (antidepressant and antipsychotic drugs) in one case and antidepressant chemotherapy ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197812000-00021
更新日期:1978-12-01 00:00:00
abstract::A septic course suggestive of intra-abdominal abscess followed surgery in a small child with a perforated appendix. Usual diagnostic studies, fluoroscopy, and rectal and wound exploration failed to localized an abscess. The use of gallium 67 scanning accurately localized multiple abscesses which were successfully drai...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197610000-00038
更新日期:1976-10-01 00:00:00
abstract::Gastrosplenic fistula resulting from erosion of a primary splenic lymphoma is a rare cause of massive upper gastrointestinal hemorrhage associated with benign peptic ulcer disease, gastric Crohn's disease, gastric adenocarcinoma, and primary gastric and splenic lymphomas. Upper intestinal hemorrhage can be successfull...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::Most of the surgical procedures proposed for the treatment of fecal incontinence associated with prolapse are associated with considerable morbidity and mortality. We used a modified Thiersch procedure with a Silastic mesh implant (Dow-Corning 501-3) on a series of 12 patients over a period of 2 1/2 years. Nine patien...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198603000-00012
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:A significant percentage of high school students participate in athletics, and of those participating, at least one third will experience a sport-related injury. Despite the high risk of injury, there are few guidelines on what type of medical coverage should be provided for high school athletics. Although v...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000199749.22741.5e
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the real-world use of various weight loss techniques and to compare the effectiveness of nontraditional methods with diet and exercise in helping nongeriatric adults lose weight. METHODS:A cross-sectional analysis of the 2005-2010 National Health and Nutrition Examination Survey was performed. A...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000130
更新日期:2014-07-01 00:00:00
abstract::Payment systems in the US healthcare system have rewarded physicians for services and attempted to control healthcare spending, with rewards and penalties based upon projected goals for future spending. The incorporation of quality goals and alternatives to fee-for-service was introduced to replace the previous system...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000626
更新日期:2017-04-01 00:00:00
abstract::Chronic myelomonocytic leukemia (CMML) is a relatively rare, heterogeneous syndrome classified as a myelodysplastic syndrome according to the French-American-British classification system. The patient's presenting symptom was a pigmented skin nodule that, although common for cases of acute monoblastic leukemia, is pec...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000054224.50737.4C
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:To characterize pain and exposure after Prolift placement and identify risk factors. METHODS:A case series of women who underwent Prolift vaginal mesh were surveyed. Pain was assessed using a visual analog scale. Exposure was evaluated clinically. RESULTS:Of 183 eligible patients, 160 completed the survey,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000377
更新日期:2015-12-01 00:00:00
abstract::The use of silver wire retention sutures requires added operating room time and expense, and it incurs the potential hazards of caught viscera, the possibility of more adhesions, leakage of intraperitoneal fluid through the exit wound, mild infection of exit wounds, and, on removal of the sutures, pain despite sedatio...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197905000-00013
更新日期:1979-05-01 00:00:00
abstract::We present a case of renal cell carcinoma extending into the inferior vena cava and resulting in total occlusion. Perioperative transesophageal echocardiography allowed us to assess cardiac function, follow the extent of vascular involvement, and prevent embolization of tumor and air. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199402000-00027
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:The objective of this population-based study was to examine the relationship between race, socioeconomic characteristics (socioeconomic status, SES), physician density, and colon cancer incidence in Alabama. METHODS:Data for 5,788 colon cancer cases from 1996 to 1999 provided by the Alabama Statewide Cancer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000184844.01148.10
更新日期:2005-11-01 00:00:00
abstract::Primary squamous cell carcinoma of the breast is a rare cancer. Published reports of prognosis are variable, and most studies are case reports of one or a few patients. We report an additional case of squamous cell carcinoma of the breast occurring in a 53-year-old black woman. In reviewing the reported cases of this ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199605000-00013
更新日期:1996-05-01 00:00:00
abstract::Sections from 879 consecutive breast biopsies performed for clinically and grossly benign disease between 1962 and 1966 were reviewed. Twenty-four cases of undiagnosed lobular carcinoma in situ or atypical lobular hyperplasia and six cases of intraductal papillary carcinoma were found. Only one patient later developed...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197804000-00004
更新日期:1978-04-01 00:00:00
abstract::Since 1965, 330 patients have received chronic dialysis treatment at the Nashville VA Hospital. Home hemodialysis training was established in 1968, and a unique class format has been used since 1970. Despite the national trend of fewer patients beginning home dialysis each year, more than 50 percent of our patients ha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197712000-00016
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Pneumonia is a leading infectious cause of morbidity and mortality in the United States. The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have published treatment guidelines for community-acquired pneumonia (CAP) based upon the site of acquisition and specific pathogen ris...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318287fe71
更新日期:2013-03-01 00:00:00
abstract::Acute methemoglobinemia is a medical emergency that can rapidly become fatal. A substantial number of drugs, including topical preparations, can precipitate this condition. I report a rare example of severe, acute methemoglobinemia caused by oropharyngeal anesthesia with topical benzocaine spray for orogastric intubat...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199709000-00018
更新日期:1997-09-01 00:00:00
abstract::Tramadol (Ultram) is a new analgesic agent with a dual mechanism of action that includes weak agonistic effects at the mu-opioid receptor as well as inhibition of neurotransmitter (serotonin, norepinephrine) re-uptake. Although it has proven to be a safe and effective agent for the control of pain, adverse effects can...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199708000-00010
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Hyponatremia is a frequent condition in elderly patients. In diagnostic workup, a 24-hour urine sample is used to measure urinary osmolality and urinary sodium concentration necessary to confirm the diagnosis of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). This study was undertake...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31819b0e06
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To perform a needs assessment to determine the extent to which hospitalist providers recognize and intervene upon obese patients in the hospital setting. METHODS:A chart review was performed for patients admitted to the hospitalist service at Johns Hopkins Bayview Medical Center between September 1 and Octob...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181dfd715
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:Pancreatic steatosis in adults has been proposed to be associated with obesity; however, data on pancreatic steatosis in children are lacking. Our study aimed to measure the prevalence of pancreatic steatosis in children and to examine its association with obesity and nonalcoholic fatty liver disease. METHO...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000432
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The appearance of normal and injured cruciate ligaments on magnetic resonance imaging (MRI) has been well described in the literature. Few studies have reported on changes found on sequential imaging of injured posterior cruciate ligaments (PCLs) during the healing process, however. METHODS:Ten consecutive ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::A three-year prospective study during the entire course of preventive therapy with isoniazid (INH) for recently infected hospital employees was undertaken to evaluate the risk of developing INH-related hepatic injury. Results of clinical and laboratory tests at 1, 2, 6, and 12 months were correlated to ascertain the s...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197702000-00009
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:We sought to determine the frequency of anserine bursitis (AB) in Koreans with osteoarthritis (OA) of the knee and its relationship to age, sex, and radiographic severity of OA, and to evaluate its response to various forms of therapy. METHODS:In a retrospective study, we reviewed the charts of patients wit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Hypochlorhydric states such as atrophic gastritis and partial gastrectomy have long been known to cause iron deficiency anemia. However, studies to date have failed to show a similar association with omeprazole, a proton pump inhibitor that also produces achlorhydria. These studies, however, have primarily involved no...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000110405.63179.69
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:The objective of the study was to determine whether treatment with protease inhibitors is associated with unprotected sexual behavior. METHODS:A total of 592 HIV-infected persons recruited from statewide public clinics in nonurban Alabama communities completed an assessment that, among other variables, elic...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract::We have reviewed 60 consecutive cases, occurring in 57 patients, of intramedullary fixation of fractures of the midshaft of the tibia done over a ten-year period with the Lottes nail. Of 50 acute fractures, 38 were open fractures, nailed after adequate irrigation and debridement; the other 12 were closed fractures. Th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198104000-00015
更新日期:1981-04-01 00:00:00