Abstract:
PURPOSE:Bone morphogenetic proteins (BMPs) are a group of growth factors that are implicated in intestinal growth, morphogenesis, differentiation, and homeostasis. The role of the BMP signaling cascade in stimulation of cell proliferation after massive small bowel resection is unknown. The purpose of this study was to evaluate the role of BMP signaling during intestinal adaptation in a rat model of short bowel syndrome (SBS). METHODS:Male rats were divided into two groups: Sham rats underwent bowel transection and SBS rats underwent a 75 % bowel resection. Parameters of intestinal adaptation, enterocyte proliferation and apoptosis were determined 2 weeks after operation. Illumina's Digital Gene Expression analysis was used to determine the BMP signaling gene expression profiling. BMP-related genes and protein expression were determined using real-time PCR, Western blotting and immunohistochemistry. RESULTS:From the total number of 20,000 probes, 8 genes related to BMP signaling were investigated. From these genes, five genes were found to be up-regulated in jejunum (BMP1-10 %, BMP2-twofold increase, BMP3-10 %, BMP2R-12 % and STAT3-28 %) and four genes to be up-regulated in ileum (BMP1-16 %, BMP2-27 %, BMP3-10 %, and STAT3-20 %) in SBS vs sham animals with a relative change in gene expression level of 10 % or more. SBS rats also demonstrated a significant increase in BMP2 and STAT3 mRNA and protein levels (determined by real-time PCR and Western blot) compared to control animals. CONCLUSION:Two weeks following massive bowel resection in rats, the BMP signaling pathway is stimulated. BMP signaling may serve as an important mediator of reciprocal interactions between the epithelium and the underlying mesenchymal stroma during intestinal adaptation following massive bowel resection in a rat.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Sukhotnik I,Berkowitz D,Dorfman T,Halabi S,Pollak Y,Bejar J,Bitterman A,Coran AGdoi
10.1007/s00383-015-3829-2subject
Has Abstractpub_date
2016-02-01 00:00:00pages
169-74issue
2eissn
0179-0358issn
1437-9813pii
10.1007/s00383-015-3829-2journal_volume
32pub_type
杂志文章abstract::Spontaneous prenatal closure of gastroschisis (GS) is rare and usually associated with atresia of the midgut. We describe a case of GS diagnosed at 20 weeks' gestation that resolved spontaneously in utero. At delivery the infant had an ileus. A laparotomy with a jejunocolostomy was performed, but she died at 2 months ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-002-0815-2
更新日期:2002-09-01 00:00:00
abstract::The majority of congenital diaphragmatic hernias (CDH) occur through the foramen of Bochdalek; herniation through the foramen of Morgagni (MH) is rare. Fifteen children (12 males and 3 females) with congenital MH (7 right, 3 left, 5 bilateral) were treated over a period of 15 years, comprising 11% of a total of 135 ch...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100653
更新日期:2002-03-01 00:00:00
abstract::Mortality rates in neonatal surgery have dropped markedly, illustrating the enormous progress made. Yet, new questions have arisen. To mention one, health care budgets have tightened. It follows that the effects of medical interventions should be weighted against their costs. As evidence was particularly sparse, we se...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-007-2045-0
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:To describe the management of cavoatrial extension of nephroblastoma in a developing country. PATIENTS AND METHODS:Of 406 consecutive children with Wilms tumour, 40 (10%) presented with tumour extension into the inferior vena cava (IVC) (30), right atrium or right ventricle and form the inception cohort. Of th...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2667-5
更新日期:2010-12-01 00:00:00
abstract::Peri-catheter calcification is an unusual and previously unreported complication of central venous (CV) catheterization in infants. A 1. 9 Fr Silastic CV catheter was placed in a term infant for administration of total parenteral nutrition and antibiotics following intra-abdominal sepsis. The catheter was removed, wit...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050418
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:Evaluate the management of hydrocephalus in pediatric patients in the Eastern Democratic Republic of Congo by a general surgeon. METHODS:Retrospective review of a single institution in the province of North Kivu. Patient charts and surgical notes were reviewed from 2003 to 2016. RESULTS:116 procedures were pe...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4238-0
更新日期:2018-04-01 00:00:00
abstract::Premature male ischiopagus tetrapus twins weighing 2.2 kg were born unexpectedly. They required initial ventilation for respiratory distress syndrome and an emergency laparotomy for intestinal obstruction at 10 days of age. At 8 months of age, formal separation was carried out. Primary skin closure was possible withou...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01372144
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:The optimal management of simple hepatic cysts (SHCs) remains controversial. A retrospective review was carried out to evaluate the clinical presentation and surgical consideration of children with SHCs and outcome of management at our institution. METHODS:We performed a retrospective review of all patients di...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3509-7
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung's disease. The aim of this study was to evaluate the safety of our technique. METHODS:Patients with suspected Hirschsprung's disease who underwent punch biopsy, including our original "K-PUNCH" method using an S-...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-4010-2
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To show whether Alvarado, Eskelinen, Lintula and Ohmann scoring systems have predictive values in diagnosing acute appendicitis in children. METHODS:Sixty patients with suspected acute appendicitis were prospectively evaluated. Alvarado, Eskelinen, Lintula and Ohmann scores were calculated separately for each ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3467-0
更新日期:2014-03-01 00:00:00
abstract:AIM OF STUDY:Few studies have evaluated the incidence of familial vesicoureteral reflux (VUR) among multiple gestation births. The purpose of this study was to determine the incidence and characteristics of VUR in twins in a large cohort of families with VUR. METHODS:Between 1998 and 2010, data were collected on 251 f...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2821-0
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS:We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent su...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3925-y
更新日期:2016-08-01 00:00:00
abstract::Accessory hepatic tissue, unlike accessory splenic and pancreatic tissue, is rare and has a limited and almost exclusively sub diaphragmatic distribution. Fewer than ten cases of intrathoracic ectopic liver have been reported so far in the literature. This paper reports a case that caused a diagnostic dilemma. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830000520
更新日期:2001-07-01 00:00:00
abstract::The successful management of faecal incontinence can dramatically improve the quality of life of affected children. The introduction of the non-refluxing, catheterisable appendico-caecostomy provides the opportunity to treat previously resistant patients. Over a 6-year period, 29 children had a Malone antegrade contin...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050342
更新日期:1998-07-01 00:00:00
abstract::The loss of esophageal length in long-gap esophageal atresia or obliteration of the esophageal lumen due to stricture may require major operative reconstruction. A number of procedures have been developed to allow anatomic replacement of the esophagus. The gastric transposition requires a single cervical anastomosis a...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-010-2736-9
更新日期:2010-12-01 00:00:00
abstract::The management of a critical airway in infants and toddlers with congenital tracheal stenosis (CTS) continues to be an enormous challenge to the surgeon. Until recently, this condition often proved fatal. Improvements in surgical techniques, anesthetic management, and postoperative critical care have resulted in succe...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830050028
更新日期:2000-01-01 00:00:00
abstract::The issues of sexual function and fertility are becoming relevant in patients with posterior urethral valves (PUV), as more of them reach adulthood. To evaluate the semen of post-pubertal patients with PUV as a determinant of future fertility, all such patients (age >16 years) attending the follow-up urology clinic of...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830100679
更新日期:2002-03-01 00:00:00
abstract::Between 1993-2002 we used both diagnostic and operative laparoscopy in the management of five cases of persistent müllerian duct syndrome (BMDS). Two siblings from two different families accounted for four of the cases. They presented with cryptorchidism and inguinal hernias. The diagnosis was established during diagn...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-0984-7
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:Pyriform sinus fistula (PSF), which originates from the third or fourth branchial pouch remnant, is relatively rare. In young children and adults, it is characterized by lateral neck infections and suppurative thyroiditis, while neonatal PSF presents as a large cervical cystic mass and causes respiratory distre...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-011-3008-z
更新日期:2012-01-01 00:00:00
abstract::Infected intra-abdominal cystic lymphangiomas are very rare. We report a case of a purulent mesenteric cyst, histologically a cystic lymphangioma, w which developed in a 1-year-old girl who presented with marked abdominal distension and high fever. Magnetic resonance imaging revealed that the huge cystic lesion occupi...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00174584
更新日期:1996-12-01 00:00:00
abstract::Confirmation of the clinical diagnosis of Hirschsprung's disease on standard rectal suction biopsy requires demonstration of aganglionosis in 60 adequate serial sections of submucosa. Positive staining for acetylcholinesterase (AChE), demonstrating an increase in nerve fibres within the lamina propria, muscularis muco...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050237
更新日期:1998-01-01 00:00:00
abstract:AIM:The Ncx/Hox11L.1 gene is required for adequate development of enteric neurons in mice and Ncx/Hox11L.1 deficient (Ncx-/-) mice are used as a model for human intestinal neuronal dysplasia (IND) because of similar histopathology (hyperganglionosis), however, some 50% of Ncx-/- mice develop megacolon with a caliber ch...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2451-6
更新日期:2009-11-01 00:00:00
abstract::Retrocaval ureter is abnormal looping of the proximal ureter behind the inferior vena cava. The aberrant anatomy results in the compression of the ureter causing hydronephrosis. This is a very infrequent cause of hydronephrosis in children. Association of retrocaval ureter with a stone in the looping segment of the ur...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2607-4
更新日期:2010-08-01 00:00:00
abstract:INTRODUCTION:Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS:From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal c...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3537-3
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:Three-dimensional (3D) imaging instead of two-dimensional (2D) computed tomography (CT) for diagnosis and preoperative planning in infants and young children with complex liver tumors is a promising technique for precision hepatectomy. METHODS:This study was a retrospective analysis of 26 infants and youn...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3864-7
更新日期:2016-04-01 00:00:00
abstract:AIM:The objective of the present study was to evaluate the diagnostic methods, concomitant organ injuries, factors affecting mortality and morbidity, treatment methods, and outcomes of patients treated for traumatic gastrointestinal (GI) perforation. MATERIALS AND METHODS:We conducted a retrospective review of the med...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3963-5
更新日期:2016-11-01 00:00:00
abstract::The Malone antegrade enema (MACE) and the caecostomy button (CB) are two methods of achieving colonic lavage in constipated children with faecal soiling. We reviewed our experience with the MACE and CB, aiming to compare results, complications, and outcomes. Between June 1998 and August 2002, 37 children (15 boys) und...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1220-9
更新日期:2004-07-01 00:00:00
abstract::The aim of this study was to determine whether barium enema reduction (BER) is safe and effective in patients with a long duration of intussusception. Over the last 17 years, 104 patients were admitted to our hospital with a diagnosis of intussusception. All except 1 with peritonitis underwent BER primarily. Of the 10...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050526
更新日期:1999-01-01 00:00:00
abstract::Around the 30th week of gestation, patients with gastroschisis (GS) develop chronic inflammatory reactions on the serosal surface of the eventrated loops of intestine that lead to severe hyperfibrinogenemia and hypercoagulability, particularly if they are born prematurely. This result was found on comparison of coagul...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00183729
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:Laparoscopic-assisted anorectoplasty (LAARP) is a minimally invasive procedure in which the levator ani muscle is left to potentially improve postoperative fecal continence. This study aimed to retrospectively evaluate postoperative complications and long-term outcomes of fecal continence after LAARP and compar...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4323-4
更新日期:2018-10-01 00:00:00