Abstract：
PURPOSE:Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS:We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent surgery at a single institution between 1995 and 2015. RESULTS:Nineteen patients were identified with a median age at operation of 16.6 years (IQR 13.5-18.9). The most common histology was solid pseudopapillary neoplasm (SPN) (n = 13), followed by pancreatic neuroendocrine tumor (n = 3), serous cystadenoma (n = 2) and pancreatoblastoma (n = 1). Operative procedures included formal pancreatectomy (n = 17), enucleation (n = 1) and central pancreatectomy (n = 1). SPNs were noninvasive in all but one case with perineural, vascular and lymph node involvement. Seventeen patients (89.5 %) are currently alive and disease free at a median follow-up of 5.7 (IQR 3.7-10.9) years. Two patients died: one with metastatic insulinoma and another with SPN who developed peritoneal carcinomatosis secondary to a concurrent rectal adenocarcinoma. CONCLUSIONS:Pediatric pancreatic tumors are a heterogeneous group of neoplastic lesions for which surgery can be curative. SPN is the most common histology, is characterized by low malignant potential and in selected cases can be safely and effectively treated with a tissue-sparing resection and minimally invasive approach.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Sacco Casamassima MG,Gause CD,Goldstein SD,Abdullah F,Meoded A,Lukish JR,Wolfgang CL,Cameron J,Hackam DJ,Hruban RH,Colombani PMdoi
10.1007/s00383-016-3925-ysubject
Has Abstractpub_date
2016-08-01 00:00:00pages
779-88issue
8eissn
0179-0358issn
1437-9813pii
10.1007/s00383-016-3925-yjournal_volume
32pub_type
杂志文章abstract：:The morphogenesis of the external genitalia of human fetuses (16-250 mm crown-rump [CR] length, 6-26 weeks of gestation) obtained after medical termination of pregnancy were studied. Differential development (male/female) started after 50 mm CR length (9 weeks). At that time the external genitalia consisted of a cylin...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01076950
更新日期：1997-07-01 00:00:00
abstract：:A neonate with a constellation of unusual congenital deformities associated with pulmonary agenesis is reported. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050603
更新日期：1999-07-01 00:00:00
abstract：:Allgrove syndrome is a rare genetic disorder typically manifested by alacrima, achalasia, and adrenal insufficiency, and is one of the rare causes of achalasia in infants. While the gold standard for achalasia treatment in adults is an esophageal myotomy with fundoplication, a standard treatment for infantile achalasi...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-014-3493-y
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:No protocol exists for prophylaxis or therapeutic management of peripherally inserted central catheter (PICC) related deep venous thrombosis (DVT) in children. Currently, very few patients are provided prophylaxis for DVT. In this study, we analyzed our current practice of PICC placement to identify the fr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3259-y
更新日期：2013-05-01 00:00:00
abstract：:To categorize variant persistent müllerian-duct derivatives (MDD) in males and determine their related clinical presentations for further management, five male patients with retained MDDs from abnormal müllerian remnants were studied. They comprised one patient with persistent müllerian-duct syndrome, one with transve...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0718-2
更新日期：2002-09-01 00:00:00
abstract：AIMS AND OBJECTIVES:Hirschsprung's disease-associated enterocolitis (HAEC) is the most serious complication of Hirschsprung's disease (HSCR). HAEC occurs in 17-50% of patients with HSCR and may occur before or after a properly performed pull-through operation. The pathogenesis of HAEC is poorly understood. It is well r...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-017-4178-0
更新日期：2018-02-01 00:00:00
abstract：:The presacral cystic teratoma in an infant is reported. The cyst consisted solely of central nervous system tissue. This pathologic finding is extremely rare. A review of the literature reveals no previous report of a teratoma arising in this manner. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0831-2
更新日期：2002-12-01 00:00:00
abstract：:With advances in neonatology, there is an increasing need for central vascular access in extremely small (<1,000 g) premature infants. Although the use of peripherally inserted central venous lines have become common practice, surgeons still frequently perform central venous line placements via cut-down in difficult a...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1474-x
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVES:This study reviews the results of our previously described modification of the minimally invasive (Nuss) procedure for correction of pectus excavatum. It utilizes a subxyphoid incision with central fixation to maximize safe bar passage and minimize bar displacement. METHODS:Consecutive patients corrected wi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4195-z
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Adnexal torsion is a gynecologic emergency, requiring intervention for tissue preservation. At our institution, torsion is managed by pediatric surgeons or gynecologists. We evaluated differences between specialties to streamline evaluation for children with gynecological emergencies, develop a clinical pathway...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04782-1
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:We aim to evaluate the diagnostic performance and relationship between clinical characteristics, imaging findings, and final diagnosis for the neonatal contrast enema (CE). METHODS:Retrospective 10-year review of all neonatal CEs including imaging findings, clinical information, indication, and final diagnosis...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04701-4
更新日期：2020-09-01 00:00:00
abstract：:Pediatric germ cell tumors comprise 1-3% of all malignant pediatric tumors and are found in variable locations. We present the case of a term 3.7 kg neonate who was found to have a giant liver mass at birth, later determined to be an immature teratoma arising from the hepatoduodenal ligament. This case report and imag...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4123-2
更新日期：2017-09-01 00:00:00
abstract：:The presentation of congenital diaphragmatic hernia (CDH) at birth may fall outside the typical features (cyanosis, tachypnea and respiratory failure), manifesting, instead, also with others pictures that make the diagnosis difficult or even impossible. We report a case of CDH presenting as a pneumothorax and a perfor...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-2000-0
更新日期：2008-03-01 00:00:00
abstract：:An unrecognised right aortic arch (RAA) found at thoracotomy may complicate the repair of oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF). This paper analyses the patient characteristics, peri-operative management, and outcome of 16 infants with a RAA, and proposes management guidelines. Between 1948 an...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050505
更新日期：1999-01-01 00:00:00
abstract：:A case of an epigastric giant-cell fibroblastoma is reported in a 6-year-old girl who had undergone a bone-marrow transplant for severe combined immunodeficiency secondary to adenosine deaminase deficiency. A small subcutaneous nodule had been excised from the epigastrium at age 12 months. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0827-y
更新日期：2003-08-01 00:00:00
abstract：:In children with severe chronic constipation, abnormal distribution of substance P (SP) and vasoactive intestinal peptide (VIP), which represent excitatory and inhibitory nerves, respectively, has been reported. The normal distribution of these neuropeptides, however, is not well known. The aim of this study was to de...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050438
更新日期：1998-11-01 00:00:00
abstract：:Bile lakes develop after hepatic portoenterostomy in some patients with biliary atresia, and have been regarded as an indication of poor prognosis. We reported that bile lakes have no epithelium of the bile duct on their wall, and are surrounded by bile ducts; however, the mechanism of bile lake formation is little kn...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-2099-z
更新日期：2008-03-01 00:00:00
abstract：:Recurrent or chronic abdominal pain can be a challenging problem when conventional diagnostic studies fail to identify the cause. It is estimated that up to one-third of children suffer from abdominal pain, and in this population recurrent pain can be even more challenging. Although recurrent right lower quadrant (RLQ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1632-1
更新日期：2006-03-01 00:00:00
abstract：:It is widely accepted that there are degenerative changes and decreased spermatogenesis in the contralateral descended testis (CDT) in unilateral undescended testis (UUDT). While some investigators have postulated that the mechanism may be related to primary (congenital) or secondary (autoimmune, vascular, and neural)...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000532
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibro...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4313-6
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:The use of general anesthesia in young children has come under increasing scrutiny due to its potential long-term neurotoxic effects. Meanwhile, regional anesthesia for surgical procedures in neonates has many advantages, including preservation of respiratory status and faster return to feeding. We describe the...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-4027-6
更新日期：2017-03-01 00:00:00
abstract：:We review a single surgeon and surgical centre's experience with congenital cystic adenomatoid malformation of the lung (CCAML) in relation to clinical spectrum, operative experience, and postoperative course. A retrospective hospital record review was done on surgically treated cases of CCAML over a 10-year period, f...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1225-4
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:Retroperitoneal teratomas (RTs) are rare among germ cell tumors and predominantly occur in infants. RTs are often difficult to manage by perioperative management. In this study, we retrospectively reviewed our series of RTs. METHODS:Seventy patients with germ cell tumors were treated from 1989 to 2015 in our i...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3938-6
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:We investigated the relationship between the affected lobe and symptom onset in prenatally diagnosed congenital pulmonary airway malformation (CPAM). METHODS:53 CPAM patients diagnosed prenatally were reviewed retrospectively by creating 2 groups according to symptom onset. Group Sneo: (symptomatic during the ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04460-x
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:Historically, the majority of patients with colonic atresia have been managed by ostomy creation at the time of initial operation; conversely, we have tended to treat the atresia with resection and anastomosis. The purpose of this study is to determine the rate of concomitant Hirschsprung's disease and to ident...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2401-3
更新日期：2009-07-01 00:00:00
abstract：PURPOSE:To evaluate early postoperative results in a case controlled study following clinical use of stem cells in extrahepatic biliary atresia (EHBA). METHODS:From July 2005 to March 2008, 30 cases of suspected EHBA were divided in two groups in an intervention study. Group A received autologous mononuclear bone marr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2712-4
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:Evaluate the management of hydrocephalus in pediatric patients in the Eastern Democratic Republic of Congo by a general surgeon. METHODS:Retrospective review of a single institution in the province of North Kivu. Patient charts and surgical notes were reviewed from 2003 to 2016. RESULTS:116 procedures were pe...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4238-0
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:Bicycling is a well-liked sporting activity in which many children participate, and bicycle accidents are one of the most common causes of abdominal injuries in children. We evaluated the characteristics and outcomes of abdominal injuries due to bicycle accidents in children. PATIENTS AND METHODS:This study wa...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3279-7
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS:From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal c...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3537-3
更新日期：2014-08-01 00:00:00
abstract：:Primary hydatid disease of the pancreas is rare. The authors report a 3-year-old girl who had a cystic mass in the head of the pancreas with no other viscera involved. At laparatomy the entire endocyst was totally extracted from the surrounding pancreatic parenchyma. The postoperative course was uneventful. She is cur...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050677
更新日期：1999-01-01 00:00:00
