Abstract:
:In children with severe chronic constipation, abnormal distribution of substance P (SP) and vasoactive intestinal peptide (VIP), which represent excitatory and inhibitory nerves, respectively, has been reported. The normal distribution of these neuropeptides, however, is not well known. The aim of this study was to determine the populations of SP- and VIP-immunoreactive nerve fibres in the circular muscle of the colon in children. Surgically resected specimens were collected from a 6-year-old girl with familial polyposis coli (total colon) and nine patients with anorectal malformations aged 0-4 years (sigmoid colon). Double-labelling immunofluorescence was employed using neuron-specific enolase (NSE) with SP and NSE with VIP to count the percentage of SP- or VIP-labelled nerve fibres. These specimens showed normal submucous and myenteric plexuses stained with NSE. The population of SP- immunoreactive fibres was 15%-21% throughout the colon, and VIP was 39% in the caecum and 63%-65% in the transverse, descending, and sigmoid colon. In the four neonatal specimens (day 1 to 4), the SP population was only 1%-6% and the VIP population was also low (22%-33%). After 3 weeks of age, the populations had stabilised at 18%-26% for SP and 52%-62% for VIP. SP-immunoreactive nerve fibres were scarce in the neonatal period, and showed a rapid increase by 3 weeks and a similar though less dramatic increase in VIP-immunoreactive fibres. VIP-immunoreactive fibres were fewer in the caecum that at other colonic levels, where they accounted for 60% of NSE-labelled fibres; the SP population, however, was comparable at all levels of the colon at about 20% of NSE-labelled fibres.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Uemura S,Hurley MR,Hutson JM,Chow CWdoi
10.1007/s003830050438subject
Has Abstractpub_date
1998-11-01 00:00:00pages
66-70issue
1-2eissn
0179-0358issn
1437-9813journal_volume
14pub_type
杂志文章abstract:PURPOSE:This study aimed to characterize the surgical complications, especially gastroesophageal reflux disease (GERD), intestinal adhesion obstruction (IAO), and diaphragmatic hernia recurrence, in patients with congenital diaphragmatic hernia (CDH). METHODS:Between January 1995 and December 2013, we determined the i...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3575-x
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To compare open repair (OR) with thoracoscopic repair (TR) for congenital diaphragmatic hernia (CDH) in neonates. METHODS:Twenty-four neonatal CDH cases diagnosed prenatally or within 6 h of birth at our institute from 2002 to 2012 with mild pulmonary hypertension managed without inhaled nitric oxide, were stu...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-013-3382-9
更新日期:2013-11-01 00:00:00
abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue tumour in children. This is the first time a facial RMS metastatic to the pancreas is reported. The patient was a 3-year-old boy with a symptomatic solitary pancreatic metastasis of a primary facial RMS, with already one relapse in a submental lymph node. Since thi...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2539-z
更新日期:2010-03-01 00:00:00
abstract::Biliary atresia (BA) is a common cause of infantile cholestasis. Disease progression leads to intra hepaticfibrosis, and thus to the development of PH and EV. Our objective has been to study the relationship between procollagen-III-peptide (PIIIP) and the severity of EV in children with BA after Kasai operation. Child...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830200007
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:We evaluated the effectiveness of prophylactic mesenteric lymphatic ligation in preventing iatrogenic chylous fistulae in abdominal neuroblastoma surgery. METHOD:All patients who underwent resection of abdominal neuroblastoma between years 2002 and 2013 were included. A change in surgical strategy commenced fr...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3581-z
更新日期:2014-10-01 00:00:00
abstract::Fetal skin wounds heal scarlessly while adult wounds scar. Fetal wound healing occurs in a physiologically hypoxic environment whereas in adult wound healing, cells have to acutely adapt to hypoxia caused by locally impaired blood supply. We examined the expression of hypoxia-inducible factor 1 (HIF-1), a potent trans...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050735
更新日期:2000-01-01 00:00:00
abstract::A new instrument for suction rectal biopsy in infants suspected of having Hirschsprung's disease is described that can be completely dismantled, physically cleaned, lubricated, and heat-sterilised. These attributes are new and are absolutely critical today. The instrument has been used in 60 patients (ca. 180 biopsies...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01194812
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Haemolytic uraemic syndrome (HUS) is the commonest childhood cause of acute renal failure. Peritoneal dialysis peritonitis (PDP) is a well-recognised complication, with some children requiring surgical intervention (SI). The aim of this study is to determine whether the presence of enteric organisms in cases of...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3833-6
更新日期:2016-03-01 00:00:00
abstract::A 45,X/46,Xidic(Y)(q11.2) mosaicism was found in a 4-year-old boy. The clinical appearance was characterized by bilateral cryptorchidism, penoscrotal hypospadias, short penis, and coarctation of the aorta. The latter is the only abnormality also seen in Turner syndrome. A biopsy of the gonads revealed normal prepubert...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050731
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:The Morgagni hernia (MH) accounts for 3-4% of congenital diaphragmatic hernias. There is a paucity of data regarding this rare defect. The purpose of this study is to describe the characteristics of children with MH, surgical approaches for repair, and patient outcomes. METHODS:Pediatric patients (ages 0-...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4078-3
更新日期:2017-07-01 00:00:00
abstract:AIMS AND OBJECTIVES:Hirschsprung's disease-associated enterocolitis (HAEC) is the most serious complication of Hirschsprung's disease (HSCR). HAEC occurs in 17-50% of patients with HSCR and may occur before or after a properly performed pull-through operation. The pathogenesis of HAEC is poorly understood. It is well r...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-017-4178-0
更新日期:2018-02-01 00:00:00
abstract::Controversy exists on the optimal age for elective resection of asymptomatic congenital pulmonary airway malformation. Current recommendations vary widely, highlighting the overall lack of consensus. A systematic search of Embase, MEDLINE, CINAL, and CENTRAL was conducted in January 2016. Identified citations were scr...
journal_title:Pediatric surgery international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00383-017-4079-2
更新日期:2017-06-01 00:00:00
abstract::Atypical mycobacterial disease is common in children in Australia. Over 22 years, records were kept prospectively by the senior author. The diagnosis was confirmed in 118 patients, either by culture or by the combination of a positive skin test plus typical histology. There were 46 boys and 72 girls with a median age ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-002-0840-1
更新日期:2002-12-01 00:00:00
abstract::Pulmonary sequestrations are non-functional masses of lung tissue lacking normal communication with the tracheobronchial tree and systemic-circulation-derived blood supply. The disconnection between the normal airway and pulmonary arterial supply prevents pulmonary sequestrations from participating in respiration whil...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4072-9
更新日期:2017-07-01 00:00:00
abstract::True duplicate exstrophy is a rare and interesting congenital anomaly. We are adding a case to the previously reported seven cases in the world literature. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830000557
更新日期:2002-03-01 00:00:00
abstract:INTRODUCTION:Hepatoportoenterostomy (HPE) with the Kasai procedure is the treatment of choice for biliary atresia (BA) as the initial surgery. However, the appropriate level of dissection level of the fibrous cone (FC) of the porta hepatis (PH) is frequently unclear, and the procedure sometimes results in unsuccessful ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3799-4
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To clarify the status of segmental dilatation of the intestine (SD) using a nationwide retrospective cohort survey. METHODS:Supported by the Ministry of Health, Labour and Welfare in Japan, preliminary questionnaires requesting the numbers of SD cases from 2000 to 2009 were sent to 161 Japanese major institute...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3788-7
更新日期:2015-11-01 00:00:00
abstract::Intestinal neuronal dysplasia is a controversial form of dysganglionosis that has been described both as an isolated disorder and in association with Hirschsprung's disease. It has been blamed for the bad outcome of bowel function in patients operated on for Hirschsprung's disease. According to various authors, intest...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-1035-0
更新日期:2003-12-01 00:00:00
abstract::Africa faces a triple burden of disease; HIV, tuberculosis and malaria. Despite this, its population is expected to double over the next 45 years. There is a dire shortage of medical specialists and many countries lack suitably qualified doctors to train medical specialists. Videoconferencing offers the opportunity to...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-2085-5
更新日期:2008-02-01 00:00:00
abstract::Children and adolescents affected by ulcerative colitis (UC) frequently require colectomy because of refractory or chronic symptoms. The aim of this paper is to present our experience and 10-year follow-up results of 28 patients who underwent endorectal pull-through (ERPT) as surgical treatment for UC, with special re...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1232-5
更新日期:2004-08-01 00:00:00
abstract::Rhabdoid tumour of the kidney is not common. Presentation of such a lethal tumour along with blunt abdominal trauma is even rarer. We report such a case of Rhabdoid tumour of kidney which presented as renal trauma, and discuss the diagnostic difficulties and rapidly fatal outcome. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003839900290
更新日期:2000-01-01 00:00:00
abstract::The loss of esophageal length in long-gap esophageal atresia or obliteration of the esophageal lumen due to stricture may require major operative reconstruction. A number of procedures have been developed to allow anatomic replacement of the esophagus. The gastric transposition requires a single cervical anastomosis a...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-010-2736-9
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the applicability of the National Institute for Health and Clinical Excellence (NICE) guidelines for imaging studies in children under the age of three with first urinary tract infection (UTI). METHODS:In our cohort of 112 patients, we gathered data regarding the occur...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-012-3257-5
更新日期:2013-03-01 00:00:00
abstract::In a retrospective study, intraoperative photos and video documentations of 884 children demonstrate that inguinal hernias and their recurrences are aspects of a full spectrum, which ranges from fully closed internal inguinal rings (IIR) and small openings to all-the way-down-into-the-scrotum open processus; 92% of th...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-007-2018-3
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:To report the authors' experience in the management of perforated choledochal cyst with bile peritonitis (PCC) in children. METHODS:Medical records of all children undergoing surgery for PCC at our hospital from May, 2005 to January, 2013 were reviewed. RESULTS:Twenty seven patients were identified, with a me...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3461-6
更新日期:2014-03-01 00:00:00
abstract::Our presentation of four cases demonstrates the essential features of limb-body wall complex (LBWC), representing a compound anomaly pattern in body-wall defects. The diagnosis of this entity is based on two of the three following characteristics: (1) exencephaly/encephalocele and facial clefts; (2) thoraco- and/or ab...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000497
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS:We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent su...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3925-y
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:Congenital lung abnormalities are rare malformations increasingly detected early by prenatal ultrasound. Whether management of these frequently asymptomatic lesions should be surgical or conservative is an unresolved issue. The necessary prospective studies are limited by the absence of a widely accepted practi...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-017-4062-y
更新日期:2017-06-01 00:00:00
abstract:AIMS:The aim of this study was to assess the usefulness of PAS, β-catenin and Ki-67 in categorising hepatoblastomas (HBs) and their significance in predicting prognosis. In addition, we have also documented the various chemotherapy induced histologic changes in HBs. METHOD:In this retrospective observational study of ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-017-4115-2
更新日期:2017-09-01 00:00:00
abstract:AIM:Prepubertal testicular tumors are rare in children. We aim to present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single medical center of China. MATERIALS AND METHODS:A total of 67 children (≤ 14 years) treated for testicular tumor at ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4366-6
更新日期:2018-12-01 00:00:00