Identification and localization of a Novel Invasin of Plasmodium falciparum.


:Plasmodium falciparum is the causative organism for the most severe form of malaria among humans. The clinical symptoms are accredited to the asexual stage of parasite life cycle, involving merozoite invasion of erythrocyte, development and re-invasion into the new erythrocyte. Interaction of parasite proteins present on the surface or secreted from apical organelles with the host receptors is indispensable for the invasion process. Identification and elucidation of precise localization and function of these proteins will not only enhance our understanding of this process but will also aid in the progress of development of treatment strategies against malaria. Here we report the identification and localization of a novel protein, PfAEP (P. falciparum Apical Exonemal Protein) (PF3D7_1137200/ PF11_0383) which is conserved across Plasmodium species. Transcription and translation analysis have confirmed its expression in the schizont stage of P. falciparum. Super-resolution microscopy in schizonts and merozoites revealed its localization in the exonemes of P. falciparum.


Mol Biochem Parasitol


Hans N,Relan U,Dubey N,Gaur D,Chauhan VS




Has Abstract


2015-08-01 00:00:00














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    authors: Holzer TR,Mishra KK,LeBowitz JH,Forney JD

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    journal_title:Molecular and biochemical parasitology

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    authors: Atkinson BG,Podesta RB

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    authors: Vasconcelos EJ,Terrão MC,Ruiz JC,Vêncio RZ,Cruz AK

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    abstract::Genetic manipulation of Plasmodium falciparum in culture through transfection has provided numerous insights into the molecular and cell biology of this parasite. The procedure is rather cumbersome, and is limited by the number of drug-resistant markers that can be used for selecting transfected parasites. Here we rep...

    journal_title:Molecular and biochemical parasitology

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    pub_type: 杂志文章


    authors: Weeks RS,Patterson JL,Stuart K,Widmer G

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    authors: Opperdoes FR,Van Roy J

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    authors: Paape D,Barrios-Llerena ME,Le Bihan T,Mackay L,Aebischer T

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    pub_type: 杂志文章


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    authors: Damasceno FS,Barisón MJ,Crispim M,Souza ROO,Marchese L,Silber AM

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    journal_title:Molecular and biochemical parasitology

    pub_type: 杂志文章


    authors: Billecocq A

    更新日期:1987-09-01 00:00:00

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    journal_title:Molecular and biochemical parasitology

    pub_type: 杂志文章


    authors: Lodes MJ,Connors VA,Yoshino TP

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    journal_title:Molecular and biochemical parasitology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Rodrigues V,Chaudhri M,Knight M,Meadows H,Chambers AE,Taylor WR,Kelly C,Simpson AJ

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Molecular and biochemical parasitology

    pub_type: 杂志文章


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    更新日期:2002-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Hall SL,Braschi S,Truscott M,Mathieson W,Cesari IM,Wilson RA

    更新日期:2011-09-01 00:00:00