Comparison of 68Ga-DOTA-JR11 PET/CT with dosimetric 177Lu-satoreotide tetraxetan (177Lu-DOTA-JR11) SPECT/CT in patients with metastatic neuroendocrine tumors undergoing peptide receptor radionuclide therapy.

Abstract:

PURPOSE:Paired imaging/therapy with radiolabeled somatostatin receptor (SSTR) antagonists is a novel approach in neuroendocrine tumors (NETs). The aim of this study was to compare tumor uptake of 68Ga-DOTA-JR11 and 177Lu-satoreotide tetraxetan (177Lu-DOTA-JR11) in patients with NETs. METHODS:As part of a prospective clinical trial, 20 patients with metastatic NETs underwent 68Ga-DOTA-JR11 PET/CT and serial imaging with 177Lu-satoreotide tetraxetan. PET/CT and SPECT/CT parameters for lesion uptake and absorbed dose of 177Lu-satoreotide tetraxetan in lesions were compared using linear regression analysis and Pearson correlation. RESULTS:A total of 95 lesions were analyzed on 68Ga-DOTA-JR11 PET/CT and 177Lu-satoreotide tetraxetan SPECT/CT. SUVs and tumor-to-normal-tissue ratios on PET/CT and SPECT/CT were significantly correlated (p < 0.01), but the degree of correlation was modest with Pearson correlation coefficients ranging from 0.3 to 0.7. Variation in intrapatient lesional correlation was observed. Nevertheless, in all patients, the lesion SUVpeak uptake ratio for 177Lu-satoreotide tetraxetan vs. 68Ga-DOTA-JR11 was high; even in those with low uptake on 68Ga-DOTA-JR11 PET/CT (SUVpeak ≤ 10), a ratio of 8.0 ± 5.2 was noted. Correlation of SUVpeak of 68Ga-DOTA-JR11 with projected 177Lu-satoreotide tetratexan-absorbed dose (n = 42) was modest (r = 0.5, p < 0.01), while excellent correlation of SUVpeak of 177Lu-satoreotide tetraxetan with projected 177Lu-satoreotide tetraxetan-absorbed dose was noted (r = 0.9, p < 0.0001). CONCLUSION:Our study shows that 68Ga-DOTA-JR11 PET can be used for patient selection and PRRT and that low tumor uptake on PET should not preclude patients from treatment with 177Lu-satoreotide tetraxetan. The ability to use single time-point SPECT/CT for absorbed dose calculations could facilitate dosimetry regimens, save costs, and improve patient convenience.

authors

Krebs S,O'Donoghue JA,Biegel E,Beattie BJ,Reidy D,Lyashchenko SK,Lewis JS,Bodei L,Weber WA,Pandit-Taskar N

doi

10.1007/s00259-020-04832-9

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

3047-3057

issue

13

eissn

1619-7070

issn

1619-7089

pii

10.1007/s00259-020-04832-9

journal_volume

47

pub_type

杂志文章
  • The prefrontal cortex: insights from functional neuroimaging using cognitive activation tasks.

    abstract::This review presents neuroimaging studies which have explored the functional anatomy of a variety of cognitive processes represented by the prefrontal cortex (PFC). Overall, these studies have demonstrated that standard prefrontal neuroactivation tasks recruit a widely distributed network within the brain of which the...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-003-1382-z

    authors: Goethals I,Audenaert K,Van de Wiele C,Dierckx R

    更新日期:2004-03-01 00:00:00

  • Comparison of two neural network classifiers in the differential diagnosis of essential tremor and Parkinson's disease by (123)I-FP-CIT brain SPECT.

    abstract:PURPOSE:To contribute to the differentiation of Parkinson's disease (PD) and essential tremor (ET), we compared two different artificial neural network classifiers using (123)I-FP-CIT SPECT data, a probabilistic neural network (PNN) and a classification tree (ClT). METHODS:(123)I-FP-CIT brain SPECT with semiquantitati...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-010-1481-6

    authors: Palumbo B,Fravolini ML,Nuvoli S,Spanu A,Paulus KS,Schillaci O,Madeddu G

    更新日期:2010-11-01 00:00:00

  • Comparison of 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography (FLT PET) and FDG PET/CT for the detection and characterization of pancreatic tumours.

    abstract:PURPOSE:Despite recent advances in clinical imaging modalities, differentiation of pancreatic masses remains difficult. Here, we tested the diagnostic accuracy of molecular-based imaging including 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) positron emission tomography (PET) and [(18)F]fluorodeoxyglucose (FDG) PET/CT in p...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2061-8

    authors: Herrmann K,Erkan M,Dobritz M,Schuster T,Siveke JT,Beer AJ,Wester HJ,Schmid RM,Friess H,Schwaiger M,Kleeff J,Buck AK

    更新日期:2012-05-01 00:00:00

  • Predictive value of early and late residual 18F-fluorodeoxyglucose and 18F-fluorothymidine uptake using different SUV measurements in patients with non-small-cell lung cancer treated with erlotinib.

    abstract:PURPOSE:To evaluate the predictive value of early and late residual (18)F-fluorodeoxyglucose (FDG) and (18)F-fluorothymidine (FLT) uptake using different SUV measurements in PET in patients with advanced non-small-cell lung cancer (NSCLC) treated with erlotinib. METHODS:We retrospectively reviewed data from 30 patient...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2118-8

    authors: Kobe C,Scheffler M,Holstein A,Zander T,Nogova L,Lammertsma AA,Boellaard R,Neumaier B,Ullrich RT,Dietlein M,Wolf J,Kahraman D

    更新日期:2012-07-01 00:00:00

  • Diagnostic accuracy of ¹¹C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma.

    abstract:PURPOSE:In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting. Therefore, in this study we aimed to assess the diagnostic role of (11)C-choline positro...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3079-5

    authors: Lopci E,Torzilli G,Poretti D,de Neto LJ,Donadon M,Rimassa L,Lanza E,Sabongi JG,Ceriani R,Personeni N,Palmisano A,Pedicini V,Comito T,Scorsetti M,Chiti A

    更新日期:2015-08-01 00:00:00

  • Feasibility of state of the art PET/CT systems performance harmonisation.

    abstract:PURPOSE:The objective of this study was to explore the feasibility of harmonising performance for PET/CT systems equipped with time-of-flight (ToF) and resolution modelling/point spread function (PSF) technologies. A second aim was producing a working prototype of new harmonising criteria with higher contrast recoverie...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-3977-4

    authors: Kaalep A,Sera T,Rijnsdorp S,Yaqub M,Talsma A,Lodge MA,Boellaard R

    更新日期:2018-07-01 00:00:00

  • Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer.

    abstract:PURPOSE:Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due to the ineffectively accumulation of HDACI in prostate cancer cells. The purpose of this work was to e...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04896-7

    authors: Chen Z,Wang X,Yang X,Xu Y,Yang Y,Wang H,Li T,Bai P,Yuan G,Chen H,Yang J,Fiedler SA,Striar R,Bernales DR,Koegel RE,Cao Q,Ran C,Xiang B,Li H,Wang C

    更新日期:2021-01-01 00:00:00

  • Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle.

    abstract:PURPOSE:Trastuzumab (Herceptin™) is often internalized following binding to Her2+ tumor cells. The objective of this study was to investigate whether trastuzumab can be used as a specific carrier to deliver antisense oligomers into Her2+ tumor cells both in vitro and in vivo. METHODS:A biotinylated MORF oligomer antis...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1201-2

    authors: Wang Y,Liu X,Chen L,Cheng D,Rusckowski M,Hnatowich DJ

    更新日期:2009-12-01 00:00:00

  • Biological characterisation of breast cancer by means of PET.

    abstract::Breast cancer is associated with increased glucose consumption and can therefore be visualised with the glucose analogue [(18)F]2-deoxy-2-fluoro-D-glucose (FDG) and positron emission tomography (PET). FDG uptake in the primary tumour can vary substantially, and specific tumour characteristics have been demonstrated to...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-004-1529-6

    authors: Buck AK,Schirrmeister H,Mattfeldt T,Reske SN

    更新日期:2004-06-01 00:00:00

  • 18F-FDG PET, genotype-corrected ACE and sIL-2R in newly diagnosed sarcoidosis.

    abstract:PURPOSE:Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. (18)F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of (18)F-FDG PET, geno...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1097-x

    authors: Keijsers RG,Verzijlbergen FJ,Oyen WJ,van den Bosch JM,Ruven HJ,van Velzen-Blad H,Grutters JC

    更新日期:2009-07-01 00:00:00

  • Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring.

    abstract:AIMS:Perivascular fat attenuation index (FAI) has emerged as a novel coronary computed tomography angiography (CCTA)-based biomarker predicting cardiovascular outcomes by capturing early coronary inflammation. It is currently unknown whether FAI adds prognostic value beyond that provided by single-photon emission compu...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-05106-0

    authors: Bengs S,Haider A,Warnock GI,Fiechter M,Pargaetzi Y,Rampidis G,Etter D,Wijnen WJ,Portmann A,Osto E,Treyer V,Benz DC,Meisel A,Fuchs TA,Gräni C,Buechel RR,Kaufmann PA,Pazhenkottil AP,Gebhard C

    更新日期:2020-11-16 00:00:00

  • Role of 18F-FLT PET/CT in suspected recurrent or residual lymphoma: final results of a pilot prospective trial.

    abstract:PURPOSE:To evaluate the role of F-18-Fluorothymidine (FLT) PET/CT in lymphoma patients with suspected recurrent or residual disease. METHODS:Adult lymphoma patients presenting with positive or equivocal F-18-FDG PET/CT at end-treatment or follow-up were prospectively addressed to an additional F-18-FLT-PET/CT. SUV max...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-019-04323-6

    authors: Zanoni L,Broccoli A,Lambertini A,Pellegrini C,Stefoni V,Lodi F,Fonti C,Nanni C,Zinzani PL,Fanti S

    更新日期:2019-07-01 00:00:00

  • Multislice CT coronary angiography: how to do it and what is the current clinical performance?

    abstract::The introduction of multislice computed tomography (MSCT) has allowed non-invasive coronary angiography. Although widely applied, extensive information on technical details of the technique is lacking. This survey offers detailed information on patient preparation, data acquisition, reconstruction and interpretation. ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-005-1856-2

    authors: Cademartiri F,Schuijf JD,Mollet NR,Malagutti P,Runza G,Bax JJ,de Feyter PJ

    更新日期:2005-11-01 00:00:00

  • Quantification of dopamine transporters in the mouse brain using ultra-high resolution single-photon emission tomography.

    abstract::Functional imaging of small animals, such as mice and rats, using ultra-high resolution positron emission tomography (PET) and single-photon emission tomography (SPET), is becoming a valuable tool for studying animal models of human disease. While several studies have shown the utility of PET imaging in small animals,...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-002-0776-7

    authors: Acton PD,Choi SR,Plössl K,Kung HF

    更新日期:2002-05-01 00:00:00

  • 18F-FDG versus 11C-choline PET/CT for the imaging of advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy: the time period during which PET/CT can reliably detect non-recurrence.

    abstract:PURPOSE:The purpose of this prospective study was to evaluate the usefulness of (18)F-fluorodeoxyglucose (FDG) and (11)C-choline positron emission tomography (PET)/computed tomography (CT) for detecting recurrences of advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy. Additionall...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-010-1400-x

    authors: Ito K,Yokoyama J,Kubota K,Morooka M,Shiibashi M,Matsuda H

    更新日期:2010-07-01 00:00:00

  • Altered serotonin transporter availability in patients with multiple sclerosis.

    abstract:PURPOSE:Modulation of the immune system by the CNS may involve serotonergic regulation via the brain serotonin transporters (SERT). This regulation may be disturbed in patients with CNS disorders including multiple sclerosis (MS). Central serotonergic mechanisms have not been investigated in MS by in vivo imaging. The ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-013-2636-z

    authors: Hesse S,Moeller F,Petroff D,Lobsien D,Luthardt J,Regenthal R,Becker GA,Patt M,Thomae E,Seese A,Meyer PM,Bergh FT,Sabri O

    更新日期:2014-05-01 00:00:00

  • A comparison of radionuclide thyroid angiography, (99m)Tc-MIBI scintigraphy and power Doppler ultrasonography in the differential diagnosis of solitary cold thyroid nodules.

    abstract::We prospectively studied 43 patients with solitary cold thyroid nodules greater than 1.5 cm in diameter to determine the comparative diagnostic value of radionuclide thyroid angiography (RTA), technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) scintigraphy and power Doppler ultrasonography (PDUS) in the different...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-003-1124-2

    authors: Demirel K,Kapucu O,Yücel C,Ozdemir H,Ayvaz G,Taneri F

    更新日期:2003-05-01 00:00:00

  • Correction to: Imaging phenotype using 18F-fluorodeoxyglucose positron emission tomography-based radiomics and genetic alterations of pancreatic ductal adenocarcinoma.

    abstract::After publication of this article we received a request from Dr. Jong Kyun Lee to have his name removed from the author list as he felt he did not fully meet the authorship criteria. The original version of this article was inadvertently published with an incorrect inclusion period of study. ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 已发布勘误

    doi:10.1007/s00259-020-04850-7

    authors: Lim CH,Cho YS,Choi JY,Lee KH,Min JH,Hyun SH

    更新日期:2020-08-01 00:00:00

  • [99mTc]Demotensin 5 and 6 in the NTS1-R-targeted imaging of tumours: synthesis and preclinical results.

    abstract:PURPOSE:The aim of this study was to evaluate the applicability of [(99m)Tc]Demotensin 5 and 6 [Formula: see text] in the targeted diagnostic imaging of neurotensin subtype 1 receptor (NTS1-R)-expressing tumours. METHODS:Labelling of Demotensin 5 and 6 with (99m)Tc was conducted by brief incubation with (99m)TcO(4) (-...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0489-z

    authors: Maina T,Nikolopoulou A,Stathopoulou E,Galanis AS,Cordopatis P,Nock BA

    更新日期:2007-11-01 00:00:00

  • Prognostic significance of stress myocardial gated SPECT among Japanese patients referred for coronary angiography: A study of data from the J-ACCESS database.

    abstract:PURPOSE:The J-ACCESS [Japanese investigation of prognosis based on gated single photon emission computed tomography (SPECT)] study found that quantitative gated myocardial SPECT (QGS) is valuable for predicting the prognosis of Japanese patients with known or suspected ischaemic heart disease. The present study evaluat...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1084-2

    authors: Momose M,Nakajima K,Nishimura T

    更新日期:2009-08-01 00:00:00

  • Predictive potential of pre-operative functional neuroimaging in patients treated with subthalamic stimulation.

    abstract:PURPOSE:The aim of this study was to investigate the predictive potential of pre-operative regional cerebral blood flow (rCBF) in the pre-supplementary motor area (pre-SMA) and clinical factors in Parkinson's disease (PD) patients treated with subthalamic nucleus (STN) stimulation. METHODS:Ten patients underwent rCBF ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-009-1198-6

    authors: Sestini S,Pupi A,Ammannati F,Ramat S,Sorbi S,Sciagrà R,Mansi L,Castagnoli A

    更新日期:2010-01-01 00:00:00

  • Comparison of (18)F-FLT PET and (18)F-FDG PET for preoperative staging in non-small cell lung cancer.

    abstract:PURPOSE:The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively compared the diagnostic efficacy of FLT PET with that of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) PET for the preoperative nodal and distant me...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0613-0

    authors: Yamamoto Y,Nishiyama Y,Kimura N,Ishikawa S,Okuda M,Bandoh S,Kanaji N,Asakura M,Ohkawa M

    更新日期:2008-02-01 00:00:00

  • In-vivo comparison of the acute retention of stem cell derivatives and fibroblasts after intramyocardial transplantation in the mouse model.

    abstract:PURPOSE:Various strategies have been applied to increase the engraftment of an intramyocardial cell transplant (Tx) to treat ischemic myocardium. Thereby, co-transplanted fibroblasts (FB) improve the long-term survival of stem cell derivatives (SCD) in a murine model of myocardial infarction. For therapeutic use, the t...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2858-8

    authors: Lang C,Lehner S,Todica A,Boening G,Zacherl M,Franz WM,Krause BJ,Bartenstein P,Hacker M,David R

    更新日期:2014-12-01 00:00:00

  • Development of a practical image-based scatter correction method for brain perfusion SPECT: comparison with the TEW method.

    abstract:PURPOSE:An image-based scatter correction (IBSC) method was developed to convert scatter-uncorrected into scatter-corrected SPECT images. The purpose of this study was to validate this method by means of phantom simulations and human studies with 99mTc-labeled tracers, based on comparison with the conventional triple e...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-005-1791-2

    authors: Shidahara M,Watabe H,Kim KM,Kato T,Kawatsu S,Kato R,Yoshimura K,Iida H,Ito K

    更新日期:2005-10-01 00:00:00

  • Myocardial perfusion scintigraphy: the evidence.

    abstract::This review summarises the evidence for the role of myocardial perfusion scintigraphy (MPS) in patients with known or suspected coronary artery disease. It is the product of a consensus conference organised by the British Cardiac Society, the British Nuclear Cardiology Society and the British Nuclear Medicine Society ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 共识发展会议,指南,杂志文章,实务指引,评审

    doi:10.1007/s00259-003-1344-5

    authors: Underwood SR,Anagnostopoulos C,Cerqueira M,Ell PJ,Flint EJ,Harbinson M,Kelion AD,Al-Mohammad A,Prvulovich EM,Shaw LJ,Tweddel AC,British Cardiac Society.,British Nuclear Cardiology Society.,British Nuclear Medicine Society.,Ro

    更新日期:2004-02-01 00:00:00

  • 68Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients.

    abstract:BACKGROUND:To report on imaging findings using 68Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS:68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. RESULTS:Out of 81 tumo...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-016-3563-6

    authors: Sathekge M,Lengana T,Modiselle M,Vorster M,Zeevaart J,Maes A,Ebenhan T,Van de Wiele C

    更新日期:2017-04-01 00:00:00

  • 131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma.

    abstract:PURPOSE:(131)Iodine metaiodobenzylguanidine ((131)I-MIBG) is a radiopharmaceutical used for scintigraphic localisation of phaeochromocytomas and paragangliomas. The experience with its therapeutic use is limited. We report our experience for the treatment of malignant phaeochromocytoma and paraganglioma. MATERIALS AND...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-007-0652-6

    authors: Gedik GK,Hoefnagel CA,Bais E,Olmos RA

    更新日期:2008-04-01 00:00:00

  • Ventilation/perfusion SPECT/CT findings in different lung lesions associated with COVID-19: a case series.

    abstract:PURPOSE:The aim of this series of cases is to show the aspects of ventilation/perfusion single-photon emission computed tomography combined with computed tomography (V/Q SPECT/CT) in patients hospitalized for COVID-19 pneumonia, with the worsening of respiratory symptoms raising the suspicion of a pulmonary embolism. P...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04920-w

    authors: Cobes N,Guernou M,Lussato D,Queneau M,Songy B,Bonardel G,Grellier JF

    更新日期:2020-09-01 00:00:00

  • PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates.

    abstract:PURPOSE:Positron emission tomography (PET) radioligands specific to α7 nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer's disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α7-nAChR-specific ra...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3209-0

    authors: Hillmer AT,Zheng MQ,Li S,Scheunemann M,Lin SF,Holden D,Labaree D,Ropchan J,Teodoro R,Deuther-Conrad W,Carson RE,Brust P,Huang Y

    更新日期:2016-03-01 00:00:00

  • (11)C-acetate as a new biomarker for PET/CT in patients with multiple myeloma: initial staging and postinduction response assessment.

    abstract:PURPOSE:We investigated the potential value of (11)C-acetate (ACT) PET/CT in characterizing multiple myeloma (MM) compared with (18)F-FDG PET/CT. Bone marrow histological and whole-body (WB) MRI findings served as the reference standards. METHODS:In this prospective study, 15 untreated MM patients (10 men and 5 women,...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-013-2520-x

    authors: Lin C,Ho CL,Ng SH,Wang PN,Huang Y,Lin YC,Tang TC,Tsai SF,Rahmouni A,Yen TC

    更新日期:2014-01-01 00:00:00