68Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients.

Abstract:

BACKGROUND:To report on imaging findings using 68Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS:68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. RESULTS:Out of 81 tumor lesions identified, 84% were identified on 68Ga-PSMA-HBED-CC PET. 68Ga-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6.86, SD, 5.68) when compared to those of primary or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011). SUVmean values of progesterone receptor-positive lesions proved not significantly different from progesterone receptor-negative lesions. SUV values derived from FDG PET/CT, available in seven patients, and 68Ga-PSMA-HBED-CC PET/CT imaging proved weakly correlated (r = 0.407, p = 0.015). CONCLUSIONS:68Ga-PSMA-HBED-CC PET/CT imaging in breast carcinoma confirms the reported considerable variation of PSMA expression on human solid tumors using immunohistochemistry.

authors

Sathekge M,Lengana T,Modiselle M,Vorster M,Zeevaart J,Maes A,Ebenhan T,Van de Wiele C

doi

10.1007/s00259-016-3563-6

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

689-694

issue

4

eissn

1619-7070

issn

1619-7089

pii

10.1007/s00259-016-3563-6

journal_volume

44

pub_type

杂志文章
  • Comparison of PSMA-HBED and PSMA-I&T as diagnostic agents in prostate carcinoma.

    abstract:PURPOSE:Gallium(68)-labelled prostate-specific membrane antigen (PSMA) radiopharmaceuticals can be used to detect prostate cancer (PCa) cells due the their over expression of PSMA. The 68Ga HBED-PSMA (PSMA-HBED) ligand has been most widely used and can be considered the current gold standard agent. Further PSMA ligands...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3699-z

    authors: McCarthy M,Langton T,Kumar D,Campbell A

    更新日期:2017-08-01 00:00:00

  • The prognostic value of amyloid imaging.

    abstract::Mild cognitive impairment is characterized by a decline in cognitive performance without interference with activities of daily living. The amnestic subtype of mild cognitive impairment progresses to Alzheimer's disease at a rate of 10-15% per year and in the majority the neuropathology is intermediate between the neur...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-012-2108-x

    authors: Gelosa G,Brooks DJ

    更新日期:2012-07-01 00:00:00

  • EANM/ESC guidelines for radionuclide imaging of cardiac function.

    abstract::Radionuclide imaging of cardiac function represents a number of well-validated techniques for accurate determination of right (RV) and left ventricular (LV) ejection fraction (EF) and LV volumes. These first European guidelines give recommendations for how and when to use first-pass and equilibrium radionuclide ventri...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,实务指引

    doi:10.1007/s00259-007-0694-9

    authors: Hesse B,Lindhardt TB,Acampa W,Anagnostopoulos C,Ballinger J,Bax JJ,Edenbrandt L,Flotats A,Germano G,Stopar TG,Franken P,Kelion A,Kjaer A,Le Guludec D,Ljungberg M,Maenhout AF,Marcassa C,Marving J,McKiddie F,Schaefer

    更新日期:2008-04-01 00:00:00

  • Clinical response assessment on DW-MRI compared with FDG-PET/CT after neoadjuvant chemoradiotherapy in patients with oesophageal cancer.

    abstract:PURPOSE:In about 30% of patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgical resection for locally advanced oesophageal cancer no vital tumour is found in the resection specimen. Accurate clinical response assessment is critical if deferral from surgery is considered in complete responders. O...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-020-04917-5

    authors: Vollenbrock SE,Voncken FEM,Lambregts DMJ,Maas M,Donswijk ML,Vegt E,Ter Beek LC,van Dieren JM,van Sandick JW,Aleman BMP,Beets-Tan RGH,Bartels-Rutten A

    更新日期:2021-01-01 00:00:00

  • Quantification of 5-HT(1A) receptors in human brain using p-MPPF kinetic modelling and PET.

    abstract::Serotonin-1A (5-HT(1A)) receptors are implicated in neurochemical mechanisms underlying anxiety and depression and their treatment. Animal studies have suggested that 4-(2'-methoxyphenyl)-1-[2'-[ N-(2"-pyridinyl)- p-[(18)F]fluorobenzamido] ethyl] piperazine ( p-MPPF) may be a suitable positron emission tomography (PET...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-001-0684-2

    authors: Sanabria-Bohórquez SM,Biver F,Damhaut P,Wikler D,Veraart C,Goldman S

    更新日期:2002-01-01 00:00:00

  • [(11)C]TASP457, a novel PET ligand for histamine H3 receptors in human brain.

    abstract:PURPOSE:The histamine H3 receptors are presynaptic neuroreceptors that inhibit the release of histamine and other neurotransmitters. The receptors are considered a drug target for sleep disorders and neuropsychiatric disorders with cognitive decline. We developed a novel PET ligand for the H3 receptors, [(11)C]TASP0410...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-016-3332-6

    authors: Kimura Y,Seki C,Ikoma Y,Ichise M,Kawamura K,Takahata K,Moriguchi S,Nagashima T,Ishii T,Kitamura S,Niwa F,Endo H,Yamada M,Higuchi M,Zhang MR,Suhara T

    更新日期:2016-08-01 00:00:00

  • The prognostic value of 18F-FDG PET/CT prior to liver transplantation for nonresectable colorectal liver metastases.

    abstract:PURPOSE:The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorecta...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-017-3843-9

    authors: Grut H,Dueland S,Line PD,Revheim ME

    更新日期:2018-02-01 00:00:00

  • Targeted alpha therapy in vivo: direct evidence for single cancer cell kill using 149Tb-rituximab.

    abstract::This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with terbium-149, an alpha-emitting radionuclide. Radio-immunotherapy with 5.5 MBq labelled antibody conjugate (1.11 GBq/mg) 2 days after an...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-003-1413-9

    authors: Beyer GJ,Miederer M,Vranjes-Durić S,Comor JJ,Künzi G,Hartley O,Senekowitsch-Schmidtke R,Soloviev D,Buchegger F

    更新日期:2004-04-01 00:00:00

  • PET/CT studies of multiple myeloma using (18) F-FDG and (18) F-NaF: comparison of distribution patterns and tracers' pharmacokinetics.

    abstract:OBJECTIVE:The aim of this prospective study is to evaluate the combined use of fluorine-18 fluorodeoxyglucose ((18) F-FDG) and fluorine-18 sodium fluoride ((18) F-NaF) PET/CT in the skeletal assessment of patients with multiple myeloma (MM) and to compare the efficacy of these two PET tracers regarding detection of mye...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-014-2721-y

    authors: Sachpekidis C,Goldschmidt H,Hose D,Pan L,Cheng C,Kopka K,Haberkorn U,Dimitrakopoulou-Strauss A

    更新日期:2014-07-01 00:00:00

  • Image fusion analysis of 99m Tc-HYNIC-octreotide scintigraphy and CT/MRI in patients with thyroid-associated orbitopathy: the importance of the lacrimal gland.

    abstract::The aim of this study was to describe the anatomical structures that show uptake of the somatostatin analogue octreotide in patients with thyroid-associated orbitopathy (TAO). The study population comprised a series of 20 TAO patients attending the out-patient thyroid clinic and 12 patients presenting head or neck tum...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-003-1207-0

    authors: Kainz H,Bale R,Donnemiller E,Gabriel M,Kovacs P,Decristoforo C,Moncayo R

    更新日期:2003-08-01 00:00:00

  • Myocardial perfusion scintigraphy: the evidence.

    abstract::This review summarises the evidence for the role of myocardial perfusion scintigraphy (MPS) in patients with known or suspected coronary artery disease. It is the product of a consensus conference organised by the British Cardiac Society, the British Nuclear Cardiology Society and the British Nuclear Medicine Society ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 共识发展会议,指南,杂志文章,实务指引,评审

    doi:10.1007/s00259-003-1344-5

    authors: Underwood SR,Anagnostopoulos C,Cerqueira M,Ell PJ,Flint EJ,Harbinson M,Kelion AD,Al-Mohammad A,Prvulovich EM,Shaw LJ,Tweddel AC,British Cardiac Society.,British Nuclear Cardiology Society.,British Nuclear Medicine Society.,Ro

    更新日期:2004-02-01 00:00:00

  • The diagnostic value of 18F-FDG PET and MRI in paediatric histiocytosis.

    abstract:PURPOSE:To analyse the diagnostic value of (18)F-FDG PET and MRI for the evaluation of active lesions in paediatric Langerhans cell histiocytosis. METHODS:We compared 21 (18)F-FDG PET scans with 21 MRI scans (mean time interval 17 days) in 15 patients (11 male, 4 female, age range 4 months to 19 years) with biopsy-pro...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-012-2278-6

    authors: Mueller WP,Melzer HI,Schmid I,Coppenrath E,Bartenstein P,Pfluger T

    更新日期:2013-02-01 00:00:00

  • Distinct patterns of medial temporal impairment in degenerative dementia: a brain SPECT perfusion study in Alzheimer's disease and frontotemporal dementia.

    abstract:PURPOSE:Medial temporal impairment can be detected clinically and by morphological imaging during Alzheimer's disease (AD), but the existence of a functional impairment in this area seems to be less well established. Yet such functional impairment is classically found in other degenerative cortical dementias, such as t...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-013-2389-8

    authors: Basely M,Ceccaldi M,Boyer L,Mundler O,Guedj E

    更新日期:2013-06-01 00:00:00

  • Usefulness and limitations of 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy.

    abstract:PURPOSE:We previously reported in a small series of patients that (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) scintigraphy tested positive in transthyretin-related (TTR) (both mutant and wild-type) but not in primary (AL) amyloidotic cardiomyopathy (AC). We extended our study to a larger cohort o...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-010-1642-7

    authors: Rapezzi C,Quarta CC,Guidalotti PL,Longhi S,Pettinato C,Leone O,Ferlini A,Salvi F,Gallo P,Gagliardi C,Branzi A

    更新日期:2011-03-01 00:00:00

  • The need for standardisation of cardiac FDG PET imaging in the evaluation of myocardial viability in patients with chronic ischaemic left ventricular dysfunction.

    abstract::The evaluation of myocardial glucose utilisation with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography is currently considered the most reliable tool for the identification of myocardial viability. However, the investigations using FDG imaging to predict improvement in left ventricular (LV) functi...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-002-0895-1

    authors: Knuuti J,Schelbert HR,Bax JJ

    更新日期:2002-09-01 00:00:00

  • [11C]Choline PET/CT detection of bone metastases in patients with PSA progression after primary treatment for prostate cancer: comparison with bone scintigraphy.

    abstract:PURPOSE:The aim of this study was to evaluate the clinical usefulness of [(11)C]choline positron emission tomography (PET)/CT in comparison with bone scintigraphy (BS) in detecting bone metastases (BM) of patients with biochemical progression after radical treatment for prostate cancer (PCa). METHODS:Seventy-eight con...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-011-1920-z

    authors: Picchio M,Spinapolice EG,Fallanca F,Crivellaro C,Giovacchini G,Gianolli L,Messa C

    更新日期:2012-01-01 00:00:00

  • Use of FET PET in glioblastoma patients undergoing neurooncological treatment including tumour-treating fields: initial experience.

    abstract:PURPOSE:We present our first clinical experience with O-(2-18F-fluoroethyl)-L-tyrosine (FET) PET in patients with high-grade glioma treated with various neurooncological therapies including tumour-treating fields (TTFields) for the differentiation of tumour progression from treatment-related changes. METHODS:We retros...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-3992-5

    authors: Ceccon G,Lazaridis L,Stoffels G,Rapp M,Weber M,Blau T,Lohmann P,Kebir S,Herrmann K,Fink GR,Langen KJ,Glas M,Galldiks N

    更新日期:2018-07-01 00:00:00

  • Feasibility of state of the art PET/CT systems performance harmonisation.

    abstract:PURPOSE:The objective of this study was to explore the feasibility of harmonising performance for PET/CT systems equipped with time-of-flight (ToF) and resolution modelling/point spread function (PSF) technologies. A second aim was producing a working prototype of new harmonising criteria with higher contrast recoverie...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-018-3977-4

    authors: Kaalep A,Sera T,Rijnsdorp S,Yaqub M,Talsma A,Lodge MA,Boellaard R

    更新日期:2018-07-01 00:00:00

  • 123I-MIBG imaging detects cardiac involvement and predicts cardiac events in Churg-Strauss syndrome.

    abstract:PURPOSE:In Churg-Strauss syndrome (CSS) it is important to detect cardiac involvement, which predicts poor prognosis. This study evaluated whether (123)I-metaiodobenzylguanidine (MIBG) scintigraphy could detect cardiac damage and predict cardiac events in CSS. METHODS:(123)I-MIBG scintigraphy was performed in 28 patie...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-010-1617-8

    authors: Horiguchi Y,Morita Y,Tsurikisawa N,Akiyama K

    更新日期:2011-02-01 00:00:00

  • Evolving role of FDG PET imaging in assessing joint disorders: a systematic review.

    abstract::Assessing joint disorders has been a relatively recent and evolving application of 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) imaging. FDG is taken up by inflammatory cells, particularly when they are active as part of an ongoing inflammatory process. Hence FDG PET has been employed to ass...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-011-1863-4

    authors: Carey K,Saboury B,Basu S,Brothers A,Ogdie A,Werner T,Torigian DA,Alavi A

    更新日期:2011-10-01 00:00:00

  • Artificial intelligence, machine (deep) learning and radio(geno)mics: definitions and nuclear medicine imaging applications.

    abstract::Techniques from the field of artificial intelligence, and more specifically machine (deep) learning methods, have been core components of most recent developments in the field of medical imaging. They are already being exploited or are being considered to tackle most tasks, including image reconstruction, processing (...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1007/s00259-019-04373-w

    authors: Visvikis D,Cheze Le Rest C,Jaouen V,Hatt M

    更新日期:2019-12-01 00:00:00

  • Variation in scanning line source sensitivity: a significant source of error in simultaneous emission-transmission tomography.

    abstract::Transmission measurement is recommended in order to accurately correct for attenuation in myocardial single-photon emission tomography (SPET) studies. It is important that transmission studies are artefact-free, otherwise the attenuation-corrected SPET studies may also be affected. An assumption in transmission studie...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-003-1439-z

    authors: Evans SG,Hutton BF

    更新日期:2004-05-01 00:00:00

  • Fully automatic diagnostic system for early- and late-onset mild Alzheimer's disease using FDG PET and 3D-SSP.

    abstract:PURPOSE:The purpose of this study was to design a fully automatic computer-assisted diagnostic system for early- and late-onset mild Alzheimer's disease (AD). METHODS:Glucose metabolic images were obtained from mild AD patients and normal controls using positron emission tomography (PET) and( 18)F-fluorodeoxyglucose (...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-005-0015-0

    authors: Ishii K,Kono AK,Sasaki H,Miyamoto N,Fukuda T,Sakamoto S,Mori E

    更新日期:2006-05-01 00:00:00

  • Implementation and evaluation of an ordered subsets reconstruction algorithm for transmission PET studies using median root prior and inter-update median filtering.

    abstract::An ordered subsets (OS) reconstruction algorithm based on the median root prior (MRP) and inter-update median filtering was implemented for the reconstruction of low count statistics transmission (TR) scans. The OS-MRP-TR algorithm was evaluated using an experimental phantom, simulating positron emission tomography (P...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-002-1046-4

    authors: Bettinardi V,Alenius S,Numminen P,Teräs M,Gilardi MC,Fazio F,Ruotsalainen U

    更新日期:2003-02-01 00:00:00

  • Novel 111In-labelled bombesin analogues for molecular imaging of prostate tumours.

    abstract:PURPOSE:It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high affinity for these GRP receptors. We demonstrated successful scintigraphic visualisation of BN recepto...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-006-0356-3

    authors: de Visser M,Bernard HF,Erion JL,Schmidt MA,Srinivasan A,Waser B,Reubi JC,Krenning EP,de Jong M

    更新日期:2007-08-01 00:00:00

  • FDG PET as a prognostic predictor in the early post-therapeutic evaluation for unresectable hepatocellular carcinoma.

    abstract:PURPOSE:To elucidate the prognostic role of post-therapeutic (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), we conducted a retrospective cohort study analysing the clinical factors that affect overall survival after non-operative therapy for unresectable hepatocellular carcinoma (HCC). METHOD...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-009-1284-9

    authors: Higashi T,Hatano E,Ikai I,Nishii R,Nakamoto Y,Ishizu K,Suga T,Kawashima H,Togashi K,Seo S,Kitamura K,Takada Y,Uemoto S

    更新日期:2010-03-01 00:00:00

  • 18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET.

    abstract:PURPOSE:The purpose of this study was to evaluate the usefulness of L-4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) as a tumor-specific probe, in comparison to 18F-FDG and 11C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. MET...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-016-3487-1

    authors: Watabe T,Ikeda H,Nagamori S,Wiriyasermkul P,Tanaka Y,Naka S,Kanai Y,Hagiwara K,Aoki M,Shimosegawa E,Kanai Y,Hatazawa J

    更新日期:2017-02-01 00:00:00

  • Initial investigation of ¹⁸F-NaF PET/CT for identification of vertebral sites amenable to surgical revision after spinal fusion surgery.

    abstract:PURPOSE:A pilot study was performed in patients with recurrent back pain after spinal fusion surgery to evaluate the ability of (18)F-NaF PET/CT imaging to correctly identify those requiring surgical intervention and to locate a site amenable to surgical intervention. METHODS:In this prospective study 22 patients with...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00259-012-2196-7

    authors: Quon A,Dodd R,Iagaru A,de Abreu MR,Hennemann S,Alves Neto JM,Sprinz C

    更新日期:2012-11-01 00:00:00

  • The value of SPECT/CT in carpal boss.

    abstract:PURPOSE:To assess the value of SPECT/CT in patients with carpal boss (CB). METHODS:In 24 wrists with CB (18 right-sided, 6 left-sided) in 21 patients, planar images and SPECT/CT images were obtained. Three patients had bilateral CB. The grade of uptake (0 absent, 1 low, 2 moderate, 3 high) on planar imaging and SPECT/...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-015-3151-1

    authors: Bhure U,Hug U,Huellner MW,Grünig H,Zander A,Del Sol Pérez Lago M,Strobel K

    更新日期:2015-11-01 00:00:00

  • Breast cancer detection using high-resolution breast PET compared to whole-body PET or PET/CT.

    abstract:PURPOSE:To compare the performance characteristics of positron emission mammography (PEM) with those of whole-body PET (WBPET) and PET/CT in women with newly diagnosed breast cancer. METHODS:A total of 178 women consented to PEM for presurgical planning in an IRB-approved protocol and also underwent either WBPET (n = ...

    journal_title:European journal of nuclear medicine and molecular imaging

    pub_type: 杂志文章

    doi:10.1007/s00259-013-2553-1

    authors: Kalinyak JE,Berg WA,Schilling K,Madsen KS,Narayanan D,Tartar M

    更新日期:2014-02-01 00:00:00