当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING期刊下所有文献 > Predictive potential of pre-operative functional neuroimaging in patients treated with subthalamic stimulation.

Predictive potential of pre-operative functional neuroimaging in patients treated with subthalamic stimulation.

Abstract：

PURPOSE:The aim of this study was to investigate the predictive potential of pre-operative regional cerebral blood flow (rCBF) in the pre-supplementary motor area (pre-SMA) and clinical factors in Parkinson's disease (PD) patients treated with subthalamic nucleus (STN) stimulation. METHODS:Ten patients underwent rCBF SPECT and motor Unified Parkinson's Disease Rating Scale (UPDRS) pre- and post-operatively during stimulation at 5 and 42 months. Statistical parametric mapping (SPM) was used to extract rCBF values in the pre-SMA because it is related with motor improvement. Post-operative outcomes included motor response to stimulation and percent improvement in UPDRS. Pre-operative predictors were explored by correlation test, linear regression and multivariate analyses. RESULTS:Higher pre-operative rCBF in the pre-SMA and younger age were associated with favourable outcomes at 5 and 42 months. Pre-operative rCBF results were significantly associated with baseline clinical factors. CONCLUSION:This study shows that PD patients with younger age have higher rCBF values in the pre-SMA and better outcome, thus giving the rationale to the hypothesis that STN stimulation could be considered early in the course of disease.

journal_name

Eur J Nucl Med Mol Imaging

journal_title

European journal of nuclear medicine and molecular imaging

authors

Sestini S,Pupi A,Ammannati F,Ramat S,Sorbi S,Sciagrà R,Mansi L,Castagnoli A

doi

10.1007/s00259-009-1198-6

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

12-22

issue

1

eissn

1619-7070

issn

1619-7089

journal_volume

37

pub_type

临床试验,杂志文章

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