Abstract:
PURPOSE:[(18)F]Fluoro-3'-deoxy-3'-L-fluorothymidine ([(18)F]FLT) is a tissue proliferation marker which has been widely validated as a tumour-specific imaging tracer for PET. [(18)F]FLT uptake in breast cancer is generally quantified at the region level or through first-order statistical descriptors (mean or maximum value), approaches that ignore the known complexity and heterogeneity of cancer tissues. Our aims were: (1) to validate a robust and reproducible voxel-wise approach to the quantification of [(18)F]FLT PET data in breast cancer patients, and (2) to exploit the entire distribution of the [(18)F]FLT retention estimates and their variability in the tumour region for the prediction of early treatment response. METHODS:The dataset was derived from 15 patients with stage II-IV breast cancer, scanned twice before chemotherapy and once 1 week after therapy. Using RECIST criteria (after 60 days) nine patients were categorized as responders or nonresponders to treatment. Kinetic modelling (compartmental modelling, Patlak analysis and spectral analysis with iterative filter), tissue-to-plasma ratio and standardized uptake value were applied at the voxel level. Test-retest estimates were used to assess reproducibility and reliability of the [(18)F]FLT uptake values before and after therapy for responder/nonresponder prediction. RESULTS:All the methods provided a measure of [(18)F]FLT uptake that was reliable and reproducible with ICC >0.94. Moreover, a very strong correlation was found among the methods (R (2) > 0.81). All the methods provided a limited number of outliers (<20 % in tumour), with the exception of compartmental modelling (>25 %) which was therefore excluded from the prediction analysis. Differences between before and after therapy in mean voxel-wise uptake in tumour did not allow a complete responder/nonresponder classification. In contrast, considering the full estimate distributions within the tumour (changes in median and mode between before and after therapy) improved therapy response for all the analysed methods. CONCLUSION:We showed that kinetic modelling (Patlak and spectral analysis with iterative filter) applied voxel-wise allows appropriate [(18)F]FLT uptake estimation in breast cancer with good reproducibility. Notably, this study indicated that a more comprehensive statistical investigation could improve tumour characterization and prediction of treatment response.
journal_name
Eur J Nucl Med Mol Imagingauthors
Veronese M,Rizzo G,Aboagye EO,Bertoldo Adoi
10.1007/s00259-014-2757-zsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
1781-92issue
9eissn
1619-7070issn
1619-7089journal_volume
41pub_type
杂志文章abstract:PURPOSE:To assess the radiation dosimetry and biodistribution of (99m)Tc-labeled ethylene dicysteine deoxyglucose ((99m)Tc-EC-DG) in patients with non-small-cell lung cancer (NSCLC). METHODS:Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of (99m)Tc-EC-DG (925 MBq) in seven NSCLC patients. Ra...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-009-1135-8
更新日期:2009-10-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
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更新日期:2006-10-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
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更新日期:2016-03-01 00:00:00
abstract::(124)I-PET/CT has a high clinical potential in patients with differentiated thyroid cancer (DTC). Two aspects deserve special mention: staging of recurrent or residual disease and pretherapy dosimetry. Used in combination (124)I-PET and CT allows foci of highly specific (124)I uptake to be localized with a low radiati...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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更新日期:2009-07-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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更新日期:2020-09-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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更新日期:2019-05-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
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journal_title:European journal of nuclear medicine and molecular imaging
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-017-3664-x
更新日期:2017-08-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-016-3603-2
更新日期:2017-05-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,多中心研究
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更新日期:2018-09-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
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更新日期:2003-06-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-006-0153-z
更新日期:2007-01-01 00:00:00