Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α.

abstract：:Cruciferous vegetables contain secondary metabolites termed glucosinolates that break down to products that upregulate hepatic detoxification enzymes. We have previously shown that a mixture of four major glucosinolate breakdown products from Brussels sprouts interact to produce synergistic induction of phase II detox...

journal_title：Toxicology and applied pharmacology

authors： Nho CW,Jeffery E

更新日期：2001-07-15 00:00:00

abstract：:Contamination of animal feed with mycotoxins is a major problem for fish feed mainly due to usage of contaminated ingredients for production and inappropriate storage of feed. The use of cereals for fish food production further increases the risk of a potential contamination. Potential contaminants include the mycotox...

journal_title：Toxicology and applied pharmacology

authors： Pietsch C,Bucheli TD,Wettstein FE,Burkhardt-Holm P

更新日期：2011-10-01 00:00:00

abstract：:The sensory irritant properties of ozone have been considered to be responsible for symptoms that occur in humans after exposure. This assumption has not been studied explicitly. One way to assess the aversive properties of airborne irritants is to give the exposed individual an opportunity to control the duration of ...

journal_title：Toxicology and applied pharmacology

authors： Tepper JS,Wood RW

更新日期：1985-05-01 00:00:00

abstract：:In transgenic zebrafish (Danio rerio), green fluorescent protein (GFP) is a promising marker for environmental pollutants. In using GFP, one of the obstacles which we faced was how to compare toxicity among different toxicants or among a specific toxicant in different model species with the intensity of GFP expression...

journal_title：Toxicology and applied pharmacology

authors： Seok SH,Baek MW,Lee HY,Kim DJ,Na YR,Noh KJ,Park SH,Lee HK,Lee BH,Ryu DY,Park JH

更新日期：2007-12-01 00:00:00

abstract：:Although the mechanisms responsible for chemically induced oxidative stress are under intense investigation, little is known about the effects of prooxidant chemicals on the expression of drug-metabolizing enzymes. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which...

journal_title：Toxicology and applied pharmacology

authors： Gallagher EP,Buetler TM,Stapleton PL,Wang C,Stahl DL,Eaton DL

更新日期：1995-09-01 00:00:00

abstract：:Female Golden Syrian hamsters, F-344 rats, Swiss CD-1 mice, and B6C3F1 hybrid mice were exposed 6 hr/day, 5 days/week to carcinogenic levels of vinyl chloride (VC) for 6, 12, 18, or 24 months (rats and hamsters only). Other groups of rodents were held for 6 or 12 months and then exposed for 6 or 12 months. At the end ...

journal_title：Toxicology and applied pharmacology

authors： Drew RT,Boorman GA,Haseman JK,McConnell EE,Busey WM,Moore JA

更新日期：1983-03-30 00:00:00

abstract：:Lovastatin (LOVA) is a potent inhibitor of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase widely used in clinical practice. We treated primary cultures of adult rat hepatocytes, maintained in a minimal, serum-free medium on Matrigel, a reconstituted basement membrane, with this drug, and found that the amounts of P450...

journal_title：Toxicology and applied pharmacology

authors： Kocarek TA,Schuetz EG,Guzelian PS

更新日期：1993-06-01 00:00:00

abstract：:Previous studies in this laboratory have shown that the well-characterized arginine analogue nitric oxide synthase (NOS) inhibitor, l-nitroarginine methyl ester (l-NAME) is protective against the cytotoxicity of the vesicating agent bis (2-chloroethyl) sulphide (HD). Furthermore, these protective effects were not medi...

journal_title：Toxicology and applied pharmacology

authors： Sawyer TW,Hancock JR,D'Agostino PA

更新日期：1998-08-01 00:00:00

abstract：:Promoting effects of sodium salts of phenobarbital (NaPB) and barbital (NaBB) on the development of bladder tumors were investigated in F344 male rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-nitrosobutyl-4-hydroxybutylamine (BBN). To initiate with FANFT, rats were fed 0.2% FANFT mixed ...

journal_title：Toxicology and applied pharmacology

authors： Diwan BA,Hagiwara A,Ward JM,Rice JM

更新日期：1989-04-01 00:00:00

abstract：:In many neuropathologies activated microglia and macrophages cause neurotoxicity and prolong the inflammatory response. We have previously characterized the glycosphingolipid Neurostatin (Nst), which potentially reduces these detrimental mechanisms. Nst, isolated from mammalian brain, is the GD1b ganglioside with O-ac...

journal_title：Toxicology and applied pharmacology

authors： Yanguas-Casás N,Ojalvo-Sanz AC,Martínez-Vázquez A,Goneau MF,Gilbert M,Nieto-Sampedro M,Romero-Ramírez L

更新日期：2019-08-15 00:00:00

abstract：:We previously demonstrated that cisplatin administration in mice induces muscle atrophy and an increase in the expression of two muscle-specific ubiquitin E3 ligase genes, muscle ring finger protein 1 (MuRF1), and atrophy gene-1 (atrogin-1), in skeletal muscle. Ubiquitination serves as a degradation signal in both the...

journal_title：Toxicology and applied pharmacology

authors： Sakai H,Ikeno Y,Tsukimura Y,Inomata M,Suzuki Y,Kon R,Ikarashi N,Chiba Y,Yamada T,Kamei J

更新日期：2020-09-15 00:00:00

abstract：:The disposition and metabolism of 2,3,7,8-tetrachlorodibenzofuran (TCDF) was investigated in rainbow trout (Oncorhynchus mykiss) in order to better understand the metabolic and physiological factors that modulate the fate of this extremely toxic compound in rainbow trout compared to other species. The fish were dosed ...

journal_title：Toxicology and applied pharmacology

authors： Steward AR,Maslanka R,Pangrekar J,Kumar S,Sikka HC

更新日期：1996-08-01 00:00:00

abstract：:Stress response proteins can play integral roles as modulators of cellular function and can be involved in mechanisms that are important to immune function. Metallothionein (MT), a cysteine-rich stress response protein, has been shown to play numerous roles in the cell: it serves as a reservoir of essential heavy meta...

journal_title：Toxicology and applied pharmacology

authors： Crowthers KC,Kline V,Giardina C,Lynes MA

更新日期：2000-08-01 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) are known to directly inhibit mitochondrial complex I activity as well as various mitochondrial kinases. Recent observations that complex I activity and superoxide production are modulated through cAMP-dependent phosphorylation suggests a mechanism through whi...

journal_title：Toxicology and applied pharmacology

authors： Lund KC,Wallace KB

更新日期：2008-01-01 00:00:00

abstract：:Metabolism of methylene chloride, or dichloromethane (DCM), plays a key role in determining the kinetics and carcinogenicity of the halocarbon. The objectives of this study were: to evaluate and optimize the vial equilibration technique, originally described by Sato and Nakajima (1979a), in order to characterize the h...

journal_title：Toxicology and applied pharmacology

authors： Kim C,Manning RO,Brown RP,Bruckner JV

更新日期：1996-08-01 00:00:00

abstract：:Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

journal_title：Toxicology and applied pharmacology

authors： Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

更新日期：2009-06-15 00:00:00

abstract：:Isolated rat lymphocytes in salts-glucose medium (pH 7.2) were incubated with nickel chloride, nickel acetate, nickel sulfate, and a soluble form of nickel subsulfide (0-2 mM) at 37 degrees C for 2 h. The soluble form of nickel subsulfide induced a significant increase in DNA-protein crosslinks (DPXLs) (111%) beginnin...

journal_title：Toxicology and applied pharmacology

authors： Chakrabarti SK,Bai C,Subramanian KS

更新日期：2001-02-01 00:00:00

abstract：:The immunoreactivity and pharmacokinetics of a new horse F(ab')2 scorpion antivenom and its effect on Buthus occitanus mardochei venom plasma disposition in the rabbit were studied. The scorpion venom-specific F(ab')2 affinity constant determined by immunoradiometric assay was 1.6 +/- 0.6 10(8) M-1. One group received...

journal_title：Toxicology and applied pharmacology

authors： Pépin-Covatta S,Lutsch C,Grandgeorge M,Lang J,Scherrmann JM

更新日期：1996-11-01 00:00:00

abstract：:The biological activities of the polysaccharide have attracted more and more attention in the biochemical and medical areas due to their anti-cancer effects. To estimate the anti-tumor mechanism of MAP, a novel polysaccharide from the loach, Misgurnus anguillicaudatus, the apoptosis effects of the polysaccharide on th...

journal_title：Toxicology and applied pharmacology

authors： Zhang CX,Huang KX

更新日期：2006-02-01 00:00:00

abstract：:The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

journal_title：Toxicology and applied pharmacology

authors： Rosenstein Y,Lafarge-Frayssinet C

更新日期：1983-09-15 00:00:00

abstract：:Organophosphorus esters (OP) are highly toxic chemicals used as pesticides and nerve agents. Their acute toxicity is attributed to inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) in nerve synapses. Our goal was to find a new therapeutic for protection against OP toxicity. We used a gene therapy vector, adeno-ass...

journal_title：Toxicology and applied pharmacology

authors： Li B,Duysen EG,Poluektova LY,Murrin LC,Lockridge O

更新日期：2006-07-15 00:00:00

abstract：:The zebrafish (Danio rerio) is assuming prominence in developmental genetics research. By comparison, little is known of tumorigenesis and nothing is known of carcinogen metabolism in this species. This study evaluated the ability of zebrafish to metabolize a well-characterized human carcinogen, aflatoxin B1 (AFB1), t...

journal_title：Toxicology and applied pharmacology

authors： Troxel CM,Reddy AP,O'Neal PE,Hendricks JD,Bailey GS

更新日期：1997-03-01 00:00:00

abstract：:Cyanide intoxication in mice can be antagonized by the local anesthetic, procaine HCI, either alone or in combination with sodium nitrite and/or sodium thiosulfate. Antitoxic potency, derived from LD50 values, was compared in groups of mice pretreated with sodium nitrite (43.9 mg/kg i.p.), sodium thiosulfate (1 g/kg i...

journal_title：Toxicology and applied pharmacology

authors： Jiang S,Liu Z,Zhuang X

更新日期：1998-05-01 00:00:00

abstract：:Melatonin is a neuroendocrine hormone which is currently receiving considerable attention as a treatment for jet lag, a treatment for insomnia and, by some, a possible "magic bullet" for delaying the effects of aging and preventing cancer. Production of melatonin is focused primarily in the pineal gland with very wide...

journal_title：Toxicology and applied pharmacology

authors： Blumenthal GM,Kohn MC,Portier CJ

更新日期：1997-11-01 00:00:00

abstract：:Female subjects have been reported to be less sensitive to the hyperthermic effects of 3,4-methylenedioxymethamine (MDMA) than males. Studies were designed to examine the cellular mechanisms involved in these sex sensitive differences. Gonadectomized female and male rats were treated with a 200 microg 100 microL(-1) o...

journal_title：Toxicology and applied pharmacology

authors： Wyeth RP,Mills EM,Ullman A,Kenaston MA,Burwell J,Sprague JE

更新日期：2009-02-15 00:00:00

abstract：:Hepatic systems toxicology is the integrative analysis of toxicogenomic technologies, e.g., transcriptomics, proteomics, and metabolomics, in combination with traditional toxicology measures to improve the understanding of mechanisms of hepatotoxic action. Hepatic toxicology studies that have employed toxicogenomic te...

journal_title：Toxicology and applied pharmacology

authors： Kienhuis AS,Bessems JG,Pennings JL,Driessen M,Luijten M,van Delft JH,Peijnenburg AA,van der Ven LT

更新日期：2011-01-15 00:00:00

abstract：:The number of neurons, astrocytes, reactive glia, oligodendrocytes, endothelia, and pericytes in the cortex of the calcarine sulcus of adult female Macaca fascicularis following long-term subclinical exposure to methyl mercury (MeHg) and mercuric chloride (inorganic mercury; IHg) has been estimated by use of the optic...

journal_title：Toxicology and applied pharmacology

authors： Charleston JS,Bolender RP,Mottet NK,Body RL,Vahter ME,Burbacher TM

更新日期：1994-12-01 00:00:00

abstract：:There is conflicting evidence in the literature as to the predominant mechanism and also the compositional element(s) that drives the pulmonary inflammatory response of ambient particulate matter (PM). We have investigated the inflammogenic potential of coarse (2.5-10 microm) and fine (<2.5 microm) PM from both a rura...

journal_title：Toxicology and applied pharmacology

authors： Schins RP,Lightbody JH,Borm PJ,Shi T,Donaldson K,Stone V

更新日期：2004-02-15 00:00:00

abstract：:Cadmium (Cd(2+)) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was...

journal_title：Toxicology and applied pharmacology

authors： Papritz M,Pohl C,Wübbeke C,Moisch M,Hofmann H,Hermanns MI,Thiermann H,Kirkpatrick CJ,Kehe K

更新日期：2010-06-15 00:00:00

abstract：:Previous research has shown that intraperitoneal injection of the solvent pyridine results in a dose- and time-dependent induction of hepatic P450IIE1 in rats, with a twofold increase observed at 6 hr post-treatment. However, inhalation is the primary route of exposure expected for humans exposed to pyridine in labora...

journal_title：Toxicology and applied pharmacology

authors： Hotchkiss JA,Kim SG,Novak RF,Dahl AR

更新日期：1993-01-01 00:00:00