Bacteriophage-Antibiotic Combination Strategy: an Alternative against Methicillin-Resistant Phenotypes of Staphylococcus aureus.

abstract：:Colistin is used to treat infections caused by multidrug-resistant gram-negative bacteria (MDR-GNB). It is administered intravenously in the form of colistin methanesulfonate (CMS), which is hydrolyzed in vivo to the active drug. However, pharmacokinetic data are limited. The aim of the present study was to characteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Plachouras D,Karvanen M,Friberg LE,Papadomichelakis E,Antoniadou A,Tsangaris I,Karaiskos I,Poulakou G,Kontopidou F,Armaganidis A,Cars O,Giamarellou H

更新日期：2009-08-01 00:00:00

abstract：:The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Karachalios GN

更新日期：1985-11-01 00:00:00

abstract：:The responses of 20 ampicillin-susceptible Haemophilus influenzae type b clinical isolates to the bactericidal action of ampicillin were studied by using a modified agar dilution plate count method. A well-defined paradoxical effect was observed in each of the 24-h killing curve patterns for 19 of the 20 isolates, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Woolfrey BF,Gresser-Burns ME,Lally RT

更新日期：1987-11-01 00:00:00

abstract：:Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and corre...

journal_title：Antimicrobial agents and chemotherapy

authors： McDermott PF,Tyson GH,Kabera C,Chen Y,Li C,Folster JP,Ayers SL,Lam C,Tate HP,Zhao S

更新日期：2016-08-22 00:00:00

abstract：:The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared t...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Fothergill AW,McCarthy DI,Tavakkol A

更新日期：2014-06-01 00:00:00

abstract：:β-Lactam resistance levels vary among methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, mediated by chromosomal mutations and exogenous resistance gene mecA However, MRSA resistance mechanisms are incompletely understood. A P440L mutation in the RNA polymerase β' subunit (RpoC) in slow-vancomycin-i...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Yamamoto N,Hishinuma T,Hiramatsu K

更新日期：2019-01-29 00:00:00

abstract：:Twenty strains of Staphylococcus aureus isolated from patients with endocarditis were examined in vitro for susceptibility to rifampin, nafcillin, and vancomycin and to combinations of rifampin with nafcillin or vancomycin. Minimum bactericidal concentrations of rifampin ranged from 0.0031 to 0.0125 mug/ml, of nafcill...

journal_title：Antimicrobial agents and chemotherapy

authors： Tuazon CU,Lin MY,Sheagren JN

更新日期：1978-05-01 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:Ethambutol at 3.0 micrograms/ml inhibited the transfer of label from D-[14C]glucose into the D-arabinose residue of arabinogalactan in whole cells of a drug-susceptible strain of Mycobacterium smegmatis. This inhibition began almost immediately after exposure of the cells to the drug. When drug-resistant M. smegmatis ...

journal_title：Antimicrobial agents and chemotherapy

authors： Takayama K,Kilburn JO

更新日期：1989-09-01 00:00:00

abstract：:Three Haemophilus parainfluenzae strains isolated from the urogenital tract harbored a beta-lactamase-coding 3.2-megadalton plasmid identical, by restriction endonuclease digestion and hybridization with radioactive and biotin-labeled probes specific for the TEM-1 beta-lactamase and TnA sequences, to the 3.2-megadalto...

journal_title：Antimicrobial agents and chemotherapy

authors： Martel AY,Gosselin P,Ouellette M,Roy PH,Bergeron MG

更新日期：1987-06-01 00:00:00

abstract：:The lfrA gene of Mycobacterium smegmatis encodes an efflux pump which mediates resistance to different fluoroquinolones, cationic dyes, and anthracyclines. The deletion of the lfrR gene, coding for a putative repressor and localized upstream of lfrA, increased the lfrA expression. In this study, reverse transcription-...

journal_title：Antimicrobial agents and chemotherapy

authors： Buroni S,Manina G,Guglierame P,Pasca MR,Riccardi G,De Rossi E

更新日期：2006-12-01 00:00:00

abstract：:Two bla(OKP) subgroups were found, diverging by 4.2%. Subgroups bla(OKP-A) (10 enzyme variants, pIs from 7.1 to 8.3) and bla(OKP-B) (11 variants, pI 7.1) showed similar antibiotic susceptibilities. Sequencing of rpoB, gyrA, and mdh demonstrated a concordant subdivision of Klebsiella pneumoniae phylogenetic group KpII ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fevre C,Passet V,Weill FX,Grimont PA,Brisse S

更新日期：2005-12-01 00:00:00

abstract：:A cluster of genes involved in antibiotic and heavy metal resistance has been characterized from a clinical isolate of the gram-negative bacterium Stenotrophomonas maltophilia. These genes include a macrolide phosphotransferase (mphBM) and a cadmium efflux determinant (cadA), together with the gene cadC coding for its...

journal_title：Antimicrobial agents and chemotherapy

authors： Alonso A,Sanchez P,Martínez JL

更新日期：2000-07-01 00:00:00

abstract：:Ceftriaxone in short courses has emerged as an effective alternative to chloramphenicol for the treatment of typhoid fever. To study the pharmacokinetics of ceftriaxone in acute typhoid fever, 10 febrile Nepalese adolescents and young adults with blood culture-positive illness were treated with 3 g of ceftriaxone (int...

journal_title：Antimicrobial agents and chemotherapy

authors： Acharya G,Crevoisier C,Butler T,Ho M,Tiwari M,Stoeckel K,Bradley CA

更新日期：1994-10-01 00:00:00

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with the guanine ring of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grewal J,Manavathu EK,Taylor DE

更新日期：1993-12-01 00:00:00

abstract：:The activity of methacycline against microbial L-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. The L-forms and bacteria used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hubert EG,Kalmanson GM,Montgomerie JZ,Guze LB

更新日期：1972-10-01 00:00:00

abstract：:Enzymes in the ergosterol-biosynthetic pathway are the targets of a number of antifungal agents including azoles, allylamines, and morpholines. In order to understand the response of Saccharomyces cerevisiae to perturbations in the ergosterol pathway, genome-wide transcript profiles following exposure to a number of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Bammert GF,Fostel JM

更新日期：2000-05-01 00:00:00

abstract：:Initial studies indicate that rifampin may be useful for the treatment of Staphylococcus aureus infections. Because bacterial resistance to rifampin may develop rapidly, its widespread use could result in the emergence of a resistant flora. This study evaluates the effectiveness of rifampin in reducing the nasal carri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sande MA,Mandell GL

更新日期：1975-03-01 00:00:00

abstract：:We report the detection of PER-1 extended-spectrum β-lactamase (ESBL) in a clinical non-O1, non-O139 Vibrio cholerae strain from China. ISCR1-mediated bla(PER-1) was embedded in a complex In4 family class 1 integron belonging to the lineage of Tn1696 on a conjugative IncA/C plasmid. A free 8.98-kb circular molecule pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu J,Xie L,Zhang F,Ni Y,Sun J

更新日期：2015-07-01 00:00:00

abstract：:Candida parapsilosis isolates occasionally display resistance in vitro to echinocandins and cause breakthrough infections to echinocandins. The degree of the in vivo cross-resistance among echinocandins and the fitness loss associated with caspofungin (CAS) resistance of C. parapsilosis are not well studied. We compar...

journal_title：Antimicrobial agents and chemotherapy

authors： Dimopoulou D,Hamilos G,Tzardi M,Lewis RE,Samonis G,Kontoyiannis DP

更新日期：2014-01-01 00:00:00

abstract：:In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Swick MC,Morgan-Linnell SK,Carlson KM,Zechiedrich L

更新日期：2011-02-01 00:00:00

abstract：:Tetracycline-resistant isolates of Pasteurella multocida and Pasteurella haemolytica obtained from various locations in the United States and Canada were studied to determine the distribution of the tet(H) gene. Of the 31 isolates examined, 25 were found to contain the tet(H) gene. Chromosomal or plasmid DNA obtained ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hansen LM,Blanchard PC,Hirsh DC

更新日期：1996-06-01 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Reda A,Marchillo K,Van Hecker J,Craig WA,Andes D

更新日期：2014-10-01 00:00:00

abstract：:Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaillard T,Sriprawat K,Briolant S,Wangsing C,Wurtz N,Baragatti M,Lavina M,Pascual A,Nosten F,Pradines B

更新日期：2015-08-01 00:00:00

abstract：:Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Echinococcus multilocularis Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new antiechinococcosis drugs. Metformin is an antihyperglycemic and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Loos JA,Dávila VA,Brehm K,Cumino AC

更新日期：2020-08-20 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：:An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr,Moland ES

更新日期：1986-12-01 00:00:00

abstract：:We reported previously that intraperitoneal administration of a bis(benzyl)polyamine analog, MDL 27,695, suppressed both pentavalent antimony (Sbv)-susceptible and -resistant Leishmania donovani in vivo. The present studies were performed to optimize parasite suppression by parenteral administration and to evaluate th...

journal_title：Antimicrobial agents and chemotherapy

authors： Baumann RJ,McCann PP,Bitonti AJ

更新日期：1991-07-01 00:00:00