Pharmacokinetics of ceftriaxone in patients with typhoid fever.

abstract：:For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrow...

journal_title：Antimicrobial agents and chemotherapy

authors： Rudin JE,Norden CW,Shinners EM

更新日期：1984-10-01 00:00:00

abstract：:Morinidazole, a 5-nitroimidazole antimicrobial drug, has been approved for the treatment of amoebiasis, trichomoniasis, and anaerobic bacterial infections in China. It was reported that drug-drug interaction happened after the coadministration of ornidazole, an analog of morinidazole, and rifampin or ketoconazole. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Pang X,Zhang Y,Gao R,Zhong K,Zhong D,Chen X

更新日期：2014-10-01 00:00:00

abstract：:Potential alternatives, including linezolid, adjunctive rifampin, and moxifloxacin, were evaluated against vancomycin-tolerant (P9802-020) and vancomycin-susceptible clinical isolates of Streptococcus pneumoniae in an in vitro pharmacodynamic model. Vancomycin exhibited maximal killing of 2-log(10) CFU/ml against P980...

journal_title：Antimicrobial agents and chemotherapy

authors： Cha R,Rybak MJ

更新日期：2003-06-01 00:00:00

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:The efficiencies of two dosage schedules of amikacin (2 x 10 mg/kg of body weight per 24 h and 1 x 20 mg/kg/24 h intramuscularly for 5 days) against Pseudomonas aeruginosa sepsis in rabbits were compared. Blood samples were drawn at various times after the first application, and amikacin concentrations in serum were a...

journal_title：Antimicrobial agents and chemotherapy

authors： Staneva M,Markova B,Atanasova I,Terziivanov D

更新日期：1994-05-01 00:00:00

abstract：:We encountered three clinical isolates of methicillin-resistant Staphylococcus aureus which were susceptible to netilmicin and arbekacin in the absence of beta-lactam antibiotics but which were resistant to them in the presence of beta-lactam antibiotics. One of these strains, KU5801, was used to further investigate t...

journal_title：Antimicrobial agents and chemotherapy

authors： Ida T,Okamoto R,Nonoyama M,Irinoda K,Kurazono M,Inoue M

更新日期：2002-05-01 00:00:00

abstract：:The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatel...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou Z,Griffing SM,de Oliveira AM,McCollum AM,Quezada WM,Arrospide N,Escalante AA,Udhayakumar V

更新日期：2008-02-01 00:00:00

abstract：:Preliminary studies showed that roxithromycin possessed significant in vitro activity against a variety of atypical mycobacteria such as the Mycobacterium avium complex, M. scrofulaceum, M. szulgai, M. malmoense, M. xenopi, M. marinum, and M. kansasii and rare pathogens such as M. chelonae and M. fortuitum. In this in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Bryskier A

更新日期：1994-06-01 00:00:00

abstract：:Cefmenoxime, an investigational semisynthetic cephalosporin, was evaluated in 18 pediatric patients with a variety of infections. There were seven patients with urinary tract infections, two with wound infections, two with osteomyelitis, two with abscess infections, one with cervical adenitis, one with hidradenitis, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Tansino GF,Hammerschlag MR,Congeni BL,Cox PA,Doraiswamy B,duBouchet L

更新日期：1985-10-01 00:00:00

abstract：:The in vitro and in vivo activities of modithromycin, a novel bicyclolide, against Legionella pneumophila were compared with those of telithromycin, clarithromycin, azithromycin, and levofloxacin. All the test agents decreased the intracellular growth of viable L. pneumophila bacteria over 96 h of incubation in both t...

journal_title：Antimicrobial agents and chemotherapy

authors： Sato T,Tateda K,Kimura S,Ishii Y,Yamaguchi K

更新日期：2011-04-01 00:00:00

abstract：:Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but details about its function during malaria's elusive liver stage are unclear...

journal_title：Antimicrobial agents and chemotherapy

authors： Posfai D,Eubanks AL,Keim AI,Lu KY,Wang GZ,Hughes PF,Kato N,Haystead TA,Derbyshire ER

更新日期：2018-03-27 00:00:00

abstract：:Porphyromonas gingivalis is a bacterial pathogen associated with chronic periodontitis that results in destruction of the tooth's supporting tissues. The major virulence determinants of P. gingivalis are its cell surface Arg- and Lys-specific cysteine proteinases, RgpA/B and Kgp. Lactoferrin (LF), an 80-kDa iron-bindi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dashper SG,Pan Y,Veith PD,Chen YY,Toh EC,Liu SW,Cross KJ,Reynolds EC

更新日期：2012-03-01 00:00:00

abstract：:The in vitro activities of vancomycin and teicoplanin alone and in combination with gentamicin or tobramycin were studied by time-kill techniques with 11 strains of pathogenic diphtheroids (Corynebacterium group JK). The activities of vancomycin and teicoplanin were similar (MIC for 90% of strains tested [MIC90], 1 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Spitzer PG,Eliopoulos GM,Karchmer AW,Moellering RC Jr

更新日期：1988-04-01 00:00:00

abstract：:Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asculai SS,Weis MT,Rancourt MW,Kupferberg AB

更新日期：1978-04-01 00:00:00

abstract：:Thirteen normal subjects were given 2, 3, or 4 g of ceftizoxime intravenously in a prospective single-blinded study. Serum and urine concentrations were measured for 48 h. The beta-phase serum half-life ranged from 1.4 to 1.7 h. Approximately 100% of the agent was recovered unchanged in the urine over 48 h. Six of 13 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peterson LR,Gerding DN,Van Etta LL,Eckfeldt JH,Larson TA

更新日期：1982-11-01 00:00:00

abstract：:Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to detect the prevalen...

journal_title：Antimicrobial agents and chemotherapy

authors： Saravolatz SN,Martin H,Pawlak J,Johnson LB,Saravolatz LD

更新日期：2014-06-01 00:00:00

abstract：:This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin treatment. Blood samples were analyzed using a validated liquid chromatography-tandem mass spectrometry tec...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker SL,Frantzeskaki F,Wallis SC,Diakaki C,Giamarellou H,Koulenti D,Karaiskos I,Lipman J,Dimopoulos G,Roberts JA

更新日期：2015-10-01 00:00:00

abstract：:The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul AS,Moreira CK,Elsworth B,Allred DR,Duraisingh MT

更新日期：2016-07-22 00:00:00

abstract：:Forty-nine clinical isolates of multidrug-resistant Acinetobacter baumannii were obtained from 12 hospitals in 7 prefectures throughout Japan. Molecular phylogenetic analysis revealed the clonal spread of A. baumannii sequence type 208 (ST208) and ST455 isolates harboring the armA gene and ST512 harboring the armA and...

journal_title：Antimicrobial agents and chemotherapy

authors： Tada T,Miyoshi-Akiyama T,Shimada K,Shimojima M,Kirikae T

更新日期：2014-05-01 00:00:00

abstract：:In an open, dose-finding study, a 100% cure rate was observed in patients suffering from uncomplicated gonococcal urethritis who were treated with a single oral dose of either 1.2 g (n = 10), 0.8 g (n = 11), or 0.4 g (n = 10) of cefetamet pivoxil. The MICs of cefetamet for all gonococcal strains ranged from 0.001 to 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Tio TT,Sindhunata IR,Wagenvoort JH,Michel MF,Stolz E

更新日期：1990-04-01 00:00:00

abstract：:As a consequence of blood-borne bacterial sepsis, endotoxin or lipopolysaccharide (LPS) from the cell walls of gram-negative bacteria can trigger an acute inflammatory response, leading to a series of pathological events and often resulting in death. To block this inflammatory response to endotoxin, a novel lipid A an...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi S,Kawata T,Kimura A,Miyamoto K,Katayama K,Yamatsu I,Rossignol DP,Christ WJ,Kishi Y

更新日期：1998-11-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:Shigella flexneri continues to be a major cause of diarrhea-associated illness, and increasing resistance to first-line antimicrobials complicates the treatment of infections caused by this pathogen. We investigated the pharmacodynamics of current antimicrobial treatments for shigellosis to determine the likelihood of...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Harris KA

更新日期：2017-06-27 00:00:00

abstract：:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

更新日期：1982-12-01 00:00:00

abstract：:Morphological heterogeneity of Aspergillus terreus cultures was observed during continued cultivation of amphotericin B (AMB)-resistant isolates on drug-free medium. Outgrowth leads to the emergence of multiple sectors that might result from increased growth rates at drug-free conditions. We evaluated the differences ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jukic E,Blatzer M,Binder U,Mayr L,Lass-Flörl C,Lackner M

更新日期：2017-11-22 00:00:00

abstract：:In view of increasing health threats from multiresistant pathogens, antimicrobial peptides (AMPs) and, specifically, proline-rich AMPs (PrAMPs) have been investigated in animal models. PrAMPs enter bacteria via the ABC transporter SbmA and inhibit intracellular targets. We used phage transduction (Tn10 insertion) to s...

journal_title：Antimicrobial agents and chemotherapy

authors： Krizsan A,Knappe D,Hoffmann R

更新日期：2015-10-01 00:00:00

abstract：:Drug susceptibility tests (DSTs) for Mycobacterium tuberculosis require at least 7 days of incubation. Drugs that are unstable at 37°C, such as ertapenem, are likely to be degraded before killing or inhibiting slow-growing bacteria. This would alter the MICs of these drugs, including ertapenem, leading to falsely high...

journal_title：Antimicrobial agents and chemotherapy

authors： Srivastava S,van Rijn SP,Wessels AM,Alffenaar JW,Gumbo T

更新日期：2016-04-22 00:00:00

abstract：:The accumulation of norfloxacin by Bacteroides fragilis NCTC 9343 was determined by the modified fluorescence method. The time required to achieve a steady-state concentration (SSC) after allowing B. fragilis to accumulate norfloxacin in an aerobic or an anaerobic environment was approximately 2 min; the SSC achieved ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ricci V,Piddock LJ

更新日期：2000-09-01 00:00:00

abstract：:Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Brajtburg J,Elberg S,Kobayashi GS,Medoff G

更新日期：1988-03-01 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00