Susceptibility Testing of Antibiotics That Degrade Faster than the Doubling Time of Slow-Growing Mycobacteria: Ertapenem Sterilizing Effect versus Mycobacterium tuberculosis.

abstract：:Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants that survived were identified by transposon sequencing (Tn-Seq). We determined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Molina-Quiroz RC,Lazinski DW,Camilli A,Levy SB

更新日期：2016-10-21 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and middle ear infections. The incidence of S. pneumoniae isolates that are not susceptible to penicillin has risen worldwide and may be above 20% in some countries. Beta-lactam antibiotic resistance in pneumococci is associated with sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jensen A,Valdórsson O,Frimodt-Møller N,Hollingshead S,Kilian M

更新日期：2015-01-01 00:00:00

abstract：:Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetra...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1986-07-01 00:00:00

abstract：:Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

更新日期：1995-08-01 00:00:00

abstract：:We found a heterozygous C2857T mutation (R953C) in polymerase gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less than that of the wild type. The R953C mutant shows a 4-fold decrease in discrimination of analog nucleotides relative to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Li M,Mislak AC,Foli Y,Agbosu E,Bose V,Bhandari S,Szymanski MR,Shumate CK,Yin YW,Anderson KS,Paintsil E

更新日期：2016-08-22 00:00:00

abstract：:Plasmodium falciparum, the deadliest species of malaria parasites, is dependent on glycolysis for the generation of ATP during the pathogenic red blood cell stage. Hexokinase (HK) catalyzes the first step in glycolysis, transferring the γ-phosphoryl group of ATP to glucose to yield glucose-6-phosphate. Here, we descri...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis MI,Patrick SL,Blanding WM,Dwivedi V,Suryadi J,Golden JE,Coussens NP,Lee OW,Shen M,Boxer MB,Hall MD,Sharlow ER,Drew ME,Morris JC

更新日期：2016-09-23 00:00:00

abstract：:Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial diseases. We recently completed its genome sequence and found it contains a large number of gene clusters putatively responsible for the biosynthesis of nonribosomal peptides and polyketides, including the previously ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang W,Li Y,Qian G,Wang Y,Chen H,Li YZ,Liu F,Shen Y,Du L

更新日期：2011-12-01 00:00:00

abstract：:We evaluated the diffusion of pefloxacin into the cerebrospinal fluid (CSF) in 15 patients with bacterial meningitis or ventriculitis, 14 of whom were treated with other antibiotics. Three doses of pefloxacin were administered at 12-h intervals to 11 patients intravenously and to 4 patients orally. Individual doses we...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolff M,Regnier B,Daldoss C,Nkam M,Vachon F

更新日期：1984-09-01 00:00:00

abstract：:MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-f...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ

更新日期：1997-08-01 00:00:00

abstract：:Twelve healthy volunteers participated in this randomized crossover study to compare the concentrations and recovery levels of fleroxacin and pefloxacin in urine and to assess their bactericidal activities against 12 strains of urinary pathogens with different susceptibilities over a wide range of MICs. The volunteers...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Theuretzbacher U,Kinzig M,Savov O,Sörgel F

更新日期：1998-07-01 00:00:00

abstract：:Sterol delta22-desaturase has been purified from a strain of Candida glabrata with a disruption in the gene encoding sterol 14alpha-demethylase (cytochrome P-45051; CYP51). The purified cytochrome P-450 exhibited sterol delta22-desaturase activity in a reconstituted system with NADPH-cytochrome P-450 reductase in dila...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamb DC,Maspahy S,Kelly DE,Manning NJ,Geber A,Bennett JE,Kelly SL

更新日期：1999-07-01 00:00:00

abstract：:Strains of Pseudomonas aeruginosa resistant to either gentamicin or carbenicillin have been noted since their introduction into clinical use. During a 6-month period, twice-weekly cultures were obtained from all patients treated with either gentamicin or carbenicillin and from all patients with a positive culture for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaman W,Cates C,Snelling CF,Lank B,Ronald AR

更新日期：1976-03-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes serious illness (lower respiratory illness) in preterm infants. RSV antibody-enriched immunoglobulin (RSVIG) that was lyophilized (LYO) protected against RSV lower respiratory illness. The Food and Drug Administration now requires an additional viral inactivation step (VI). We ...

journal_title：Antimicrobial agents and chemotherapy

authors： Groothuis JR,Simoes EA,Lehr MV,Kramer AA,Hemming VG,Rodriguez WJ,Arrobio J,Welliver RC,Siber GR

更新日期：1995-03-01 00:00:00

abstract：:E5531, a novel synthetic lipid A analogue, antagonizes the toxic effects of lipopolysaccharide, making it a potential intravenously administered therapeutic agent for the treatment of sepsis. This report describes the distribution of E5531 in human blood and its activity when it is associated with different lipoprotei...

journal_title：Antimicrobial agents and chemotherapy

authors： Rose JR,Mullarkey MA,Christ WJ,Hawkins LD,Lynn M,Kishi Y,Wasan KM,Peteherych K,Rossignol DP

更新日期：2000-03-01 00:00:00

abstract：:Antimalarial 9-anilinoacridines are potent inhibitors of parasite DNA topoisomerase II both in vitro and in situ. 3,6-diamino substitution on the acridine ring greatly improves parasiticidal activity against Plasmodium falciparum by targeting DNA topoisomerase II. A series of 9-anilinoacridines were investigated for t...

journal_title：Antimicrobial agents and chemotherapy

authors： Auparakkitanon S,Noonpakdee W,Ralph RK,Denny WA,Wilairat P

更新日期：2003-12-01 00:00:00

abstract：:Aggregatibacter actinomycetemcomitans, a periodontopathogen, has been associated with several systemic diseases. Herein, we report the protective effect of human lactoferrin (hLF) during A. actinomycetemcomitans bacteremia in lactoferrin knockout (LFKO(-/-)) mice. The prophylactic, concurrent, and therapeutic intraven...

journal_title：Antimicrobial agents and chemotherapy

authors： Velusamy SK,Poojary R,Ardeshna R,Alabdulmohsen W,Fine DH,Velliyagounder K

更新日期：2014-01-01 00:00:00

abstract：:Cationic antimicrobial peptides (CAPs) play important roles in host immune defenses. Plectasin is a defensin-like CAP isolated from the saprophytic fungus Pseudoplectania nigrella. NZ2114 is a novel variant of plectasin with potent activity against Gram-positive bacteria. In this study, we investigated (i) the in vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Hady WA,Deslandes A,Rey A,Fraisse L,Kristensen HH,Yeaman MR,Bayer AS

更新日期：2011-11-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:The behavioral and convulsant effects of cefazolin, a beta-lactam derivative, were studied after intraperitoneal administration to DBA/2 mice, a strain genetically susceptible to sound-induced seizures, and Swiss mice. DBA/2 mice were more susceptible to seizures induced by cefazolin than were Swiss mice. The proconvu...

journal_title：Antimicrobial agents and chemotherapy

authors： De Sarro A,Zappalá M,Chimirri A,Grasso S,De Sarro GB

更新日期：1993-07-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:Tiacumicins B and C are members of a novel group of 18-membered macrolide antibiotics with in vitro activity against Clostridium difficile. The MICs against 15 strains of C. difficile were 0.12 to 0.25 microgram/ml for tiacumicin B, 0.25 to 1 microgram/ml for tiacumicin C, and 0.5 to 1 microgram/ml for vancomycin. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Swanson RN,Hardy DJ,Shipkowitz NL,Hanson CW,Ramer NC,Fernandes PB,Clement JJ

更新日期：1991-06-01 00:00:00

abstract：:The pharmacokinetics of piperacillin were examined after single intravenous doses to three groups of male patients with creatinine clearances of greater than or equal to 60 (group I), greater than or equal to 20 but less than 60 (group II), and less than 20 (group III) ml/min per 1.73 m2. Each of 32 patients received ...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Craig WA,Bundtzen RW,Kwok FW,Gerber AU,Madsen PO

更新日期：1983-06-01 00:00:00

abstract：:Spectinomycin resistance in clinical isolates of Neisseria meningitidis and Neisseria gonorrhoeae was found to be due to mutations G1064C and C1192U (Escherichia coli numbering) in 16S rRNA genes, respectively. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Gerbaud G,Courvalin P

更新日期：2000-05-01 00:00:00

abstract：:Ampicillin, trimethoprim-sulfamethoxazole, mecillinam, nitrofurantoin, and ciprofloxacin mean resistance rates for 2,000 urinary tract isolates collected from outpatients across Canada in 1998 were 41.1, 19.2, 14.7, 5.0, and 1.8%, respectively. For Escherichia coli isolates alone (n = 1,681) comparable rates were 41. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Karlowsky JA,Harding GK,Carrie A,Mazzulli T,Low DE,Hoban DJ

更新日期：2000-04-01 00:00:00

abstract：:Parasitic diseases are of enormous public health significance in developing countries-a situation compounded by the toxicity of and resistance to many current chemotherapeutics. We investigated a focused library of 18 structurally diverse bis-acridine compounds for in vitro bioactivity against seven protozoan and one ...

journal_title：Antimicrobial agents and chemotherapy

authors： Caffrey CR,Steverding D,Swenerton RK,Kelly B,Walshe D,Debnath A,Zhou YM,Doyle PS,Fafarman AT,Zorn JA,Land KM,Beauchene J,Schreiber K,Moll H,Ponte-Sucre A,Schirmeister T,Saravanamuthu A,Fairlamb AH,Cohen FE,McKerrow

更新日期：2007-06-01 00:00:00

abstract：:Cefazolin was added to dialysis fluid in nine patients with renal failure undergoing peritoneal dialysis with 2 liters/h per exchange. With 50 mg/liter (three patients), the first measurable mean serum concentration was 3.7 mug/ml (range, 2.4 to 4.9 mug/ml) after three exchanges and was 30.3 mug/ml (range, 13.3 to 44....

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye D,Wenger N,Agarwal B

更新日期：1978-09-01 00:00:00

abstract：:The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitr...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Shea IP,Shahed M,Aguilera-Venegas B,Wilkinson SR

更新日期：2015-11-23 00:00:00

abstract：:The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobs MR,Abdelhamed AM,Good CE,Rhoads DD,Hujer KM,Hujer AM,Domitrovic TN,Rudin SD,Richter SS,van Duin D,Kreiswirth BN,Greco C,Fouts DE,Bonomo RA

更新日期：2018-12-21 00:00:00