Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand.

Abstract:

:Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).

authors

Gaillard T,Sriprawat K,Briolant S,Wangsing C,Wurtz N,Baragatti M,Lavina M,Pascual A,Nosten F,Pradines B

doi

10.1128/AAC.00345-15

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

5080-3

issue

8

eissn

0066-4804

issn

1098-6596

pii

AAC.00345-15

journal_volume

59

pub_type

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