Lifestyle-Related Factors and Total Mortality in a Mediterranean Prospective Cohort.

Abstract:

INTRODUCTION:Lifestyle-related habits have a strong influence on morbidity and mortality worldwide. This study investigates the association between a multidimensional healthy lifestyle score and all-cause mortality risk, including in the score some less-studied lifestyle-related factors. METHODS:Participants (n=20,094) of the Seguimiento Universidad de Navarra cohort were followed up from 1999 to 2018. The analysis was conducted in 2019. A 10-point healthy lifestyle score previously associated with a lower risk of major cardiovascular events was applied, assigning 1 point to each of the following items: never smoking, moderate-to-high physical activity, moderate-to-high Mediterranean diet adherence, healthy BMI, moderate alcohol consumption, avoidance of binge drinking, low TV exposure, short afternoon nap, time spent with friends, and working ≥40 hours per week. RESULTS:During a median follow-up of 10.8 years, 407 deaths were documented. In the multivariable adjusted analysis, the highest category of adherence to the score (7-10 points) showed a 60% lower risk of all-cause mortality than the lowest category (0-3 points) (hazard ratio=0.40, 95% CI=0.27, 0.60, p<0.001 for trend). In analyses of the healthy lifestyle score as a continuous variable, for each additional point in the score, a 18% relatively lower risk of all-cause mortality was observed (adjusted hazard ratio=0.82, 95% CI=0.76, 0.88). CONCLUSIONS:Adherence to a healthy lifestyle score, including some less-studied lifestyle-related factors, was longitudinally associated with a substantially lower mortality rate in a Mediterranean cohort. Comprehensive health promotion should be a public health priority.

journal_name

Am J Prev Med

authors

Ruiz-Estigarribia L,Martínez-González MÁ,Díaz-Gutiérrez J,Gea A,Rico-Campà A,Bes-Rastrollo M

doi

10.1016/j.amepre.2020.01.032

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

e59-e67

issue

2

eissn

0749-3797

issn

1873-2607

pii

S0749-3797(20)30135-5

journal_volume

59

pub_type

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