Overweight and obesity in hemophilia: a systematic review of the literature.

Abstract:

CONTEXT:As life expectancy in individuals with congenital hemophilia approaches that of the general population, we hypothesize that public health risks, including overweight and obesity, also follow a similar trend. EVIDENCE ACQUISITION:A search of the literature included terms relating to overweight, sequelae of being overweight, and hemophilia. Studies were included if they reported the frequency or clinical significance of known complications of overweight and obesity, including musculoskeletal disease, aerobic capacity, cardiovascular disease, diabetes, hyperlipidemia, decreased quality of life, and change in pharmacokinetics of infused clotting factor in hemophilia. Recommendations from medical organizations were searched for preventive and management strategies applicable to this population. EVIDENCE SYNTHESIS:Overweight and obesity are now more prevalent in the hemophilia population than previous generations, with rates similar to and, in certain subsets even higher, than that of the general population. Increased BMI leads to limitations in joint range of motion in the general population and even more so in persons with hemophilia. CONCLUSIONS:Overweight and obesity in hemophilia are an increasing problem. Simple steps can be taken to encourage patients to decrease caloric intake and increase physical activity. Prevention and management of overweight, obesity, and their sequelae must be addressed in clinical practice in order to maximize the overall health of the hemophilia population.

journal_name

Am J Prev Med

authors

Wong TE,Majumdar S,Adams E,Bergman S,Damiano ML,Deutsche J,Recht M,Healthy Weight Working Group.

doi

10.1016/j.amepre.2011.09.008

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

S369-75

issue

6 Suppl 4

eissn

0749-3797

issn

1873-2607

pii

S0749-3797(11)00621-0

journal_volume

41

pub_type

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