Abstract:
BACKGROUND:The 2002 Recommended Childhood Immunization Schedule clarified the definition of an invalid dose of vaccine as any dose administered >/=5 days before the minimum age or interval had elapsed. Any invalid dose of vaccine should be repeated. OBJECTIVE:Determine the proportion of U.S. children who received an invalid dose of vaccine, evaluate the impact on vaccination coverage levels if invalid doses were not counted, and determine the vaccine purchase cost if at least one invalid dose is repeated. METHODS:Provider-reported vaccination histories of children aged 19 to 35 months sampled by the 2000 National Immunization Survey were evaluated. Analyses were performed in 2002 after the 2002 Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedule was released. Any vaccine dose administered >/=5 days before the recommended minimum age or interval was classified as invalid. Change in vaccination coverage was determined by subtracting estimated valid-dose coverage (based on number of valid doses received) from the estimated up-to-date coverage (based on number of doses received regardless of age or spacing). RESULTS:Overall, 10.5% (+/-0.6%) of children had received at least one invalid dose of vaccine. Of the invalid doses, 51% were hepatitis B, 100% of which were the third dose; 19% were diphtheria-tetanus-pertussis (DTP/DTaP), 92% of which were the fourth dose; 12% were measles-containing vaccine (MCV); 15% were varicella vaccine; and 4% were polio vaccine, 96% of which were the first dose. Excluding invalid doses resulted in a small change in vaccination coverage: 2.2% for DTP/DTaP, 0.7% for polio, 6.5% for hepatitis B, 1.4% for MCV, and 1.7% for varicella. The vaccine purchase cost to repeat at least one invalid dose ranged from approximately $10 million (public-purchased) to approximately $18 million (private-purchased). CONCLUSIONS:Nationally about 595,000 of children aged 19 to 35 months, born between February 1997 and May 1999, received at least one invalid dose of vaccine. The cost of revaccinating these children is substantial and may have a negative impact on parents, physicians, and vaccine purchasers. Educating immunization providers regarding proper immunization timing should be conducted to reduce the administration of invalid doses of vaccines.
journal_name
Am J Prev Medjournal_title
American journal of preventive medicineauthors
Stokley S,Maurice E,Smith PJ,Klevens RMdoi
10.1016/j.amepre.2003.09.002subject
Has Abstractpub_date
2004-01-01 00:00:00pages
34-40issue
1eissn
0749-3797issn
1873-2607pii
S0749379703002770journal_volume
26pub_type
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更新日期:2020-05-01 00:00:00
abstract::Cancer is the second leading cause of morbidity and mortality in the U.S. Although reducing the number of new cancer cases is a national health goal, the continuing growth of the older adult population ensures that the burden of cancer will increase. Despite documentation of the shortage of oncologists to meet the gro...
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journal_title:American journal of preventive medicine
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journal_title:American journal of preventive medicine
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journal_title:American journal of preventive medicine
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journal_title:American journal of preventive medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2020-08-01 00:00:00
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journal_title:American journal of preventive medicine
pub_type: 杂志文章
doi:10.1016/s0749-3797(00)00315-9
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journal_title:American journal of preventive medicine
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更新日期:2021-02-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:American journal of preventive medicine
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journal_title:American journal of preventive medicine
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journal_title:American journal of preventive medicine
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:American journal of preventive medicine
pub_type: 杂志文章,随机对照试验
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