Abstract：
:The pentahydrate (alpha form) of cefazolin sodium (CEZ) exhibited sharp X-ray diffraction peaks, while the dehydrated alpha form showed weak but distinct diffraction peaks. As expected the amorphous form exhibited a diffuse and halo diffraction pattern. The X-ray procedure to estimate the degree of crystallinity of CEZ was based upon the measurement of the total scattering and the scattering from the crystalline region of the drug. The major difference in the infrared (IR) spectra among the three forms of CEZ was the absence of a spectral band at 1542 cm-1 in the amorphous form. The IR procedure was based upon the measurement of the peak percentage area ratio between the bands at 1542 and 1760 cm-1, where the latter was used as a normalizing peak. The degree of crystallinity of CEZ samples, obtained by either freeze-drying aqueous CEZ solutions or storing the crystalline forms under different humidity conditions, was determined by these two methods. Although the correlation of results by the two methods was good, the X-ray procedure appears to be superior since it can differentiate among the three solid CEZ forms, whereas IR could distinguish between only crystalline and amorphous CEZ, reproducibly.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Kamat MS,Osawa T,DeAngelis RJ,Koyama Y,DeLuca PPdoi
10.1023/a:1015984300692subject
Has Abstractpub_date
1988-07-01 00:00:00pages
426-9issue
7eissn
0724-8741issn
1573-904Xjournal_volume
5pub_type
杂志文章abstract：PURPOSE:Radial basis function artificial neural networks and theoretical descriptors were used to develop a quantitative structure-pharmacokinetic relationship for structurally diverse drug compounds. METHODS:Human bioavailability values were taken from the literature and descriptors were generated from the drug struc...
journal_title：Pharmaceutical research
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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更新日期：2019-04-23 00:00:00
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更新日期：1994-01-01 00:00:00
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