The mean dissolution time depends on the dose/solubility ratio.

Abstract:

PURPOSE:To investigate the relationship between mean dissolution time (MDT) and dose/solubility ratio (q) using the diffusion layer model. METHODS:Using the classic Noyes-Whitney equation and considering a finite dose, we derived an expression for MDT as a function of q under various conditions. q was expressed as a dimensionless quantity by taking into account the volume of the dissolution medium. Our results were applied to in vitro and in vivo data taken from literature. RESULTS:We found that MDT depends on q when q < 1 and is infinite when q > 1 and that the classic expression of MDT = 1/k. where k is the dissolution rate constant, holds only in the special case of q = 1. For the case of perfect sink conditions, MDT was found to be proportional to dose. Using dissolution data from literature with q < 1, we found better estimates of MDT when dependency on dose/ solubility ratio was considered than with the classic approach. Prediction of dissolution limited absorption was achieved for some of the in vivo drug examples examined. CONCLUSION:The mean dissolution time of a drug depends on dose/ solubility ratio, even when the model considered is the simplest possible. This fact plays an important role in drug absorption when absorption is dissolution limited.

journal_name

Pharm Res

journal_title

Pharmaceutical research

authors

Rinaki E,Dokoumetzidis A,Macheras P

doi

10.1023/a:1022652004114

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

406-8

issue

3

eissn

0724-8741

issn

1573-904X

journal_volume

20

pub_type

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