Abstract:
PURPOSE:Radial basis function artificial neural networks and theoretical descriptors were used to develop a quantitative structure-pharmacokinetic relationship for structurally diverse drug compounds. METHODS:Human bioavailability values were taken from the literature and descriptors were generated from the drug structures. All models were trained with 137 compounds and tested with a further 15, after which they were evaluated for predictive ability with an additional 15 compounds. RESULTS:The final model possessed a 10-31-1 topology and training and testing correlation coefficients were 0.736 and 0.897, respectively. Predictions for independent compounds agreed well with experimental literature values, especially for compounds that were well absorbed and/or had high observed bioavailability. Important theoretical descriptors included solubility parameters, electronic descriptors, and topological indices. CONCLUSIONS:Useful information regarding drug bioavailability was gained from drug structure alone, reducing the need for experimental methods in drug development.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Turner JV,Maddalena DJ,Agatonovic-Kustrin Sdoi
10.1023/b:pham.0000012154.09631.26subject
Has Abstractpub_date
2004-01-01 00:00:00pages
68-82issue
1eissn
0724-8741issn
1573-904Xjournal_volume
21pub_type
杂志文章abstract:PURPOSE:Some therapeutic peptides exhibit amyloidogenic properties that cause insolubility and cytotoxicity against neuronal cells in vitro. Here, we characterize the conformational change in monomeric therapeutic peptide to its fibrillar aggregate in order to prevent amyloidogenic formation during clinical application...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/b:pham.0000033016.36825.2c
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:The purpose of the current study is to evaluate the solubility advantage offered by celecoxib (CEL) amorphous systems and to characterize and correlate the physical and thermodynamic properties of CEL and its amorphous molecular dispersions containing poly(vinylpyrrolidone) (PVP). METHODS:The measurement of cr...
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/b:pham.0000033007.27278.60
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abstract:PURPOSE:The aim of the study is to investigate the effect of polymer blending on entrapment and release of ganciclovir (GCV) from poly(D,L-lactide-co-glycolide) (PLGA) microspheres using a set of empirical equations. METHODS:Two grades of PLGA, PLGA 7525 [D,L-lactide:glycolide(75:25), MW 90,000-126,000 Da] and Resomer...
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pub_type: 杂志文章
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/b:pham.0000008043.71001.43
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pub_type: 杂志文章
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更新日期:2020-02-19 00:00:00
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journal_title:Pharmaceutical research
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更新日期:1987-06-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015314314796
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1023/b:pham.0000032997.96823.88
更新日期:2004-07-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:1991-09-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2019-12-17 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1018901325842
更新日期:1993-09-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2005-07-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-007-9331-3
更新日期:2008-04-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1022652004114
更新日期:2003-03-01 00:00:00
abstract::The immune system has the ability to recognize and kill pre-cancer and cancer cells. However, with the immune system's surveillance, the survival tumor cells learn how to escape the immune system after immunoselection. Cancer immunotherapy develops strategies to overcome these problems. Nanomedicine applications in ca...
journal_title:Pharmaceutical research
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00