Indigenous tropical spastic paraparesis in Madrid (Spain). Experience on screening of human T-lymphotropic virus.

Abstract:

:We have recently documented a case of tropical spastic paraparesis by HTLV-I in a Spanish patient. HTLV-I infection is rare in Europe, and hardly ever is accompanied by symptoms, but if it does it could trigger a major health issue. This case is presented here, as well as a discussion on the situations in which HTLV-I detection is justified. An analysis was made of the HTLV diagnostic requests at our centre during 2014-2015 (n=123). The diagnostic algorithm was: 1) Enzyme immunoassay, 2) Reverse hybridization, and 3) Proviral DNA detection by PCR. The results showed several situations of HTLV screening, emphasising those related to paraparesis (22%). Seven cases of HTLV-I infection were found: five in patients from endemic regions, one in an HIV-infected patient, and the case of TSP mentioned above. HTLV-I surveillance in non-endemic regions is a challenging issue, as the cost-benefit ratio is not well-established. This case report emphasises the importance of including HTLV within the differential diagnosis of insidious spastic paraparesis.

authors

Ponce-Alonso M,Del Corral-Corral I,Ortiz-Rivera M,Anciones-Martín C,Mateos-Lindemann ML

doi

10.1016/j.eimc.2015.07.001

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

441-443

issue

7

eissn

0213-005X

issn

1578-1852

pii

S0213-005X(15)00271-2

journal_volume

35

pub_type

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