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[Factors predicting lack of adherence to highly active antiretroviral treatment].

Abstract：

INTRODUCTION:Knowledge of adherence to highly active antiretroviral treatment (HAART) and the variables associated with poor compliance is useful for the follow-up of HIV infected patients. PATIENTS, MATERIAL AND METHODS:Patients were consecutively recruited from the HIV outpatient clinics of the Hospitals of Leon and El Bierzo from January to June 2000. Patients were considered non-adherent to treatment if they failed to take 10% or more of their prescribed total dose of at least one drug during the 4 days before the interview, or if they had accumulated a delay of more than 9 days over the previous 3 months in picking up their prescribed drugs from the hospital pharmacy. Logistic regression analysis was performed with variables found to be associated with adherence in the univariate analysis. RESULTS:The methods used to determine adherence had a Kappa index of 12.6%. Among the 206 patients interviewed, 108 were considered non-adherent (52.4%; CI 95% 5 45.6-59.2). Multivariate analysis showed that the following factors were associated with poor treatment adherence: cocaine consumption in the previous six months (adjusted OR 5 5.1); patients unsure about the proper way to take prescribed treatment; (adjusted OR 5 2.5); and patients not prescribed the zidovudine-lamivudine combination (adjusted OR 5 1.9). Over one-third of patients with no variable associated with treatment adherence were considered non-compliant. CONCLUSION:Measurement of medication adherence and its predictive factors involved methodological difficulties. With the criteria used in the present study more than half the patients were considered non-compliant. The variables found to be related to poor adherence can be modified by social, psychological or health care interventions.

journal_name

Enferm Infecc Microbiol Clin

journal_title

Enfermedades infecciosas y microbiologia clinica

authors

Martín-Sánchez V,Ortega-Valín L,Pérez-Simón Mdel R,Mostaza-Fernández JL,Ortiz de Urbina-González JJ,Rodríguez-María M,Carro-Fernández JA,Cuevas-González MJ,Alcoba-Leza M,Grupo de Trabajo sobre Adhesión a TARGA en la provincia de León.

doi

10.1016/s0213-005x(02)72851-6

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

491-7

issue

eissn

0213-005X

issn

1578-1852

pii

13039658

journal_volume

pub_type

杂志文章

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[Factors predicting lack of adherence to highly active antiretroviral treatment].