Abstract：
PURPOSE:To identify key genes related to the effect of estrogen on ovarian cancer. METHODS:Microarray data (GSE22600) were downloaded from Gene Expression Omnibus. Eight estrogen and seven placebo treatment samples were obtained using a 2 × 2 factorial designs, which contained 2 cell lines (PEO4 and 2008) and 2 treatments (estrogen and placebo). Differentially expressed genes were identified by Bayesian methods, and the genes with P < 0.05 and |log2FC (fold change)| ≥0.5 were chosen as cut-off criterion. Differentially co-expressed genes (DCGs) and differentially regulated genes (DRGs) were, respectively, identified by DCe function and DRsort function in DCGL package. Topological structure analysis was performed on the important transcriptional factors (TFs) and genes in transcriptional regulatory network using tYNA. Functional enrichment analysis was, respectively, performed for DEGs and the important genes using Gene Ontology and KEGG databases. RESULTS:In total, 465 DEGs were identified. Functional enrichment analysis of DEGs indicated that ACVR2B, LTBP1, BMP7 and MYC involved in TGF-beta signaling pathway. The 2285 DCG pairs and 357 DRGs were identified. Topological structure analysis showed that 52 important TFs and 65 important genes were identified. Functional enrichment analysis of the important genes showed that TP53 and MLH1 participated in DNA damage response and the genes (ACVR2B, LTBP1, BMP7 and MYC) involved in TGF-beta signaling pathway. CONCLUSION:TP53, MLH1, ACVR2B, LTBP1 and BMP7 might participate in the pathogenesis of ovarian cancer.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Zhang ST,Zuo C,Li WN,Fu XQ,Xing S,Zhang XPdoi
10.1007/s00404-015-3833-8subject
Has Abstractpub_date
2016-02-01 00:00:00pages
421-7issue
2eissn
0932-0067issn
1432-0711pii
10.1007/s00404-015-3833-8journal_volume
293pub_type
杂志文章abstract：PURPOSE:To evaluate the results of palliative pelvic exenteration in patients with gynecologic tumors. METHODS:A retrospective analysis was carried out in 13 patients from January 2000 to December 2007. The procedure was considered palliative because of distant metastatic disease or unresectable pelvic wall disease. P...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1544-8
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:Hypoxia inducible factor-1α (HIF-1α), regulated in development and DNA damage response-1 (REDD1), and mammalian target of rapamycin (mTOR) play distinct roles in response to hypoxia. The aim of this study was to evaluate whether the HIF-1α-REDD1-mTOR-mediated hypoxic stress response also operates normally in es...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-016-4186-7
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:There is literature suggesting an intergenerational relationship between maternal and infant size for gestational age status and preterm birth, but much less is known about the contribution of paternal birth outcome to infant birth outcome. This study seeks to determine the association between paternal and infa...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05712-1
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:Although intravenous acetaminophen is commonly used for the management of postoperative pain, very limited evidence supports the usefulness of preoperative administration. The aim of this study was to determine the analgesic effect of preoperative acetaminophen on opioid consumption, pain scores, and side effec...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-011-1860-7
更新日期：2011-12-01 00:00:00
abstract：:Dihydroergotamine is a vasoactive drug which enhances venous tone, central blood volume and cardiac output but has variable effects on arterial tone. Its effect on the uterine arterial circulation is unstudied and yet dihydroergotamine is widely used to treat postural hypotension in pregnant and nonpregnant women. For...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02718385
更新日期：1992-01-01 00:00:00
abstract：:A group of 60 consecutive women admitted to the gynaecology department of Eastbourne District General Hospital for pelvic pain were entered into this study. Evidence of C. trachomatis infection of the genital tract was investigated by detection of chlamydial lipopolysaccharide antigen in the peritoneal fluid collected...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02770626
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Data on comparative outcomes of abdominal myomectomy for varying uterine sizes that could guide informed decision by women and clinicians in resource-constrained settings are scarce. OBJECTIVE:To evaluate safety of abdominal myomectomy and compare perioperative morbidities for women with very large uterine ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1460-y
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Membrane sweeping (MS) could increase the likelihood of spontaneous labor within 48 h. However, the rationale for performing routinely an intervention with the potential to induce labor in women with an uneventful pregnancy at 38 weeks of gestation is, at least, questionable. We conducted a meta-analysis of ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析
doi：10.1007/s00404-017-4643-y
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal and neonatal infectious morbidity. STUDY DESIGN:This was a prospective, randomized trial. Four hundred patients that underwent elective cesarean section between June and December 200...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-008-0845-7
更新日期：2009-07-01 00:00:00
abstract：PURPOSE:We sought to investigate the serum levels of asymmetric dimethylarginine in pregnant women with hyperemesis gravidarum. METHODS:Thirty-seven patients with hyperemesis gravidarum and 33 healthy controls were included in the study. Participants in the control group had no symptoms, or suffered only mild nausea w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1982-y
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:We compared the outcomes of bloodless emergency laparotomies for uterine rupture in twenty Jehovah's Witness (JW) women who were in a state of haemorrhagic shock with 45 other women who received blood transfusion. METHODS:The case records of twenty Jehovah's Witness patients, who underwent bloodless emergenc...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0748-7
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:To compare the efficacy of the oral dienogest versus triptorelin acetate injection for treatment of premenopausal menorrhagia and pelvic pains in women with uterine adenomyosis. METHODS:A total of 41 patients with adenomyosis suffering from pelvic pains and menorrhagia were recruited. First group was managed w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-015-3755-5
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Pheochromocytoma manifesting during pregnancy is uncommon but it is responsible for a high maternal and fetal mortality rate, especially when unrecognized. Most cases of pheochromocytoma are sporadic but they can be part of hereditary autosomal dominant syndromes. CASE:We describe a case of bilateral pheoch...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-1057-5
更新日期：2009-12-01 00:00:00
abstract：PURPOSE:Silencing of HPV oncogenes or their human host client proteins using topically applied small interfering RNA (siRNA) may be an attractive nonsurgical strategy for CIN treatment. An exploratory clinical investigation was designed to evaluate E6-AP mRNA expression levels in different stages of cervical intraepith...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-3120-5
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Membranous dysmenorrhea is a rare entity involving expulsion of fragments of endometrium retaining the shape of the uterus. The condition is often linked to high progesterone levels. An association with a chronic fatigue syndrome was never described. CASE:A 44-year-old woman with a chronic fatigue syndrome ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-008-0795-0
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:Features of polycystic ovarian syndrome (PCOS) including sonographic aspects, androgens, LH and LH/FSH ratio as well as Anti-Mullerian Hormone (AMH) were evaluated according to their diagnostic potency in detecting different degrees of PCOS severity. METHODS:80 women with PCOS diagnosed according to the Rotter...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3317-2
更新日期：2014-11-01 00:00:00
abstract：:In the original publication, the university name of the authors in the affiliations was published as University of Medical Sciences, Sabzevar, Iran. The correct university name should read as Sabzevar University of Medical Sciences, Sabzevar, Iran. ...
journal_title：Archives of gynecology and obstetrics
pub_type： 已发布勘误
doi：10.1007/s00404-018-4986-z
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:To investigate the effect of vitamin D in ovarian hyperstimulation syndrome (OHSS). METHODS:In this animal study, 28 immature female Wistar rats were divided into four groups: group 1 (control); group 2 (ovarian stimulation); group 3 (OHSS group); group 4 (OHSS + vitamin D group). All groups were killed 48 h a...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-015-3625-1
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Cervical cancer is the second most common cancer of the genital tract. Wide use of screening programs can help in prevention of cervical cancer. OBJECTIVE:To screen and evaluate the prevalence of cervical intraepithelial neoplasia (CIN) by visualization of the cervix after application of 5 % acetic acid (VI...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-3109-0
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:Robotic surgery represents the latest development in the field of minimally invasive surgery and offers many technical advantages. Despite the higher costs, this novel approach has been applied increasingly in gynecological surgery. Regarding the implementation of a new operative method; however, the most impor...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05751-8
更新日期：2020-12-01 00:00:00
abstract：INTRODUCTION:Most patients with peripheral arterial occlusion have underlying atherosclerosis. Peripheral arterial thrombosis induced by chemotherapy in gynecological malignancies is rare. CASE REPORT:A 60-year-old woman was diagnosed with ovarian carcinoma coexisting with endometrial carcinoma after surgical histopat...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-006-0193-4
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the fertility outcomes of infertile patients having proximal tubal obstruction treated with hysteroscopic tubal catheterization (HCT) for recanalization under diagnostic laparoscopy. METHODS:From January 2000 to December 2008, diagnostic laparoscopy was used to asse...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-2007-6
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:The unacceptable multiple gestation rate currently associated with in vitro fertilization (IVF) would be substantially alleviated if the routine practice of transferring more than one embryo were reconsidered. While transferring a single embryo is an effective method to reduce the clinical problem of multiple g...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-012-2396-1
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:Modest increases of serum progesterone at human chorionic gonadotrophin (hCG) administration in controlled ovarian hyperstimulation (COH) cycles have been shown to have a negative impact on pregnancy outcomes. The aim of this study was to identify early predictors of progesterone elevation at hCG. DESIGN:Pregn...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3167-y
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:We will present our experience in vulvar reconstruction using a local fascio-cutaneous flap, in order to get an easier intra-operative management and a good post-operative outcome. METHODS:Between May 2006 and December 2008, eight patients with vulvar carcinomas underwent a vulvar reconstruction, using a V-Y...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1603-1
更新日期：2010-11-01 00:00:00
abstract：:Concentration of amniotic fluid disaturated phosphatidylcholine (DSPC), factors related to cervical ripening, and histopathological evidence of chorioamnionitis were studied in 38 patients in preterm labour with intact membranes; all of them delivered spontaneously before 37 weeks. There was no correlation between the...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02718276
更新日期：1992-01-01 00:00:00
abstract：INTRODUCTION:Placenta accreta is a rare complication, which can lead to maternal morbidity and mortality. MATERIALS AND METHODS:This is a interesting case report where uterine rupture in the fundal region complicated with placenta accreta. CONCLUSION:Undiagnosed placenta accreta can lead to catastrophic consequences....
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-1329-0
更新日期：2010-07-01 00:00:00
abstract：:Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign, and almost all are localised unilaterally. Herewith, we describe an ovarian Sertoli-Leydig cell tumor in an 11-year-old girl. Serum ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004040000114
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:Prematurity is the most common cause of infant mortality and morbidity. To prevent this, the timing of parturition and its mechanisms should be understood. It is likely that inhibitor CD94/NKG2A positive decidual natural killer cells (uNK) provide for the continuation of pregnancy. Here, we aimed to evaluate wh...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-015-3978-5
更新日期：2016-08-01 00:00:00
abstract：:Early detection and repair of bladder perforation reduce postoperative morbidity. We describe two cases of bladder perforation sustained during complicated laparoscopic adhesiolysis and discuss a previously reported simple method of detecting bladder trauma during operative laparoscopy. ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0413-6
更新日期：2008-01-01 00:00:00
