Abstract：
PURPOSE:Hypoxia inducible factor-1α (HIF-1α), regulated in development and DNA damage response-1 (REDD1), and mammalian target of rapamycin (mTOR) play distinct roles in response to hypoxia. The aim of this study was to evaluate whether the HIF-1α-REDD1-mTOR-mediated hypoxic stress response also operates normally in estrogen-induced cholestasis. METHODS:Pregnant rats were administered with ethinylestradiol (EE) to induce cholestasis and then were subjected to feto-placental ischemia reperfusion (IR); as controls, one group received neither EE nor IR, and another two groups received only EE or IR. RESULTS:Giving rats either EE alone or IR alone increased placental levels of HIF-1α, REDD1, glucose transporter-1 (GLUT1), and phosphoglycerate kinase-1 (PGK1), and decreased placental mTOR and lactic dehydrogenase A (LDHA) expression compared with the control rats. Subjecting EE-treated rats to IR did not further alter placental levels of REDD1 or mTOR, while it did elevate placental HIF-1α, GLUT1, and PGK1 expression, and decline LDHA expression. By contrast, mRNA levels did not differ significantly among the four groups for any of the proteins analyzed. CONCLUSIONS:This study manifested that placental HIF-1α and its downstream glucose metabolism effectors can effectively react to hypoxia in EE-induced cholestasis rats. However, hypoxia-induced REDD1 and mTOR alternation, which responds efficiently in normal placentas, was impaired in EE-induced cholestasis placentas.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Zhou F,Chen H,Wang X,Yu P,Hu Ydoi
10.1007/s00404-016-4186-7subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1219-1226issue
6eissn
0932-0067issn
1432-0711pii
10.1007/s00404-016-4186-7journal_volume
294pub_type
杂志文章abstract：:Pregnancy zone protein (PZP, alpha 2-PAG, SP3) was found to bind to plasmin in crossed affino-immunoelectrophoresis using sodium caseinate in the first dimension gel. The plasmin presence in the PZP-plasmin complex was confirmed by addition of antiserum against plasminogen to the gel. In crossed affino-immunoelectroph...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF00932082
更新日期：1988-01-01 00:00:00
abstract：AIMS AND OBJECTIVES:To compare the three techniques of hysterectomy-total laparoscopic hysterectomy (TLH), laparoscopic assisted vaginal hysterectomy (LAVH) and non-descent vaginal hysterectomy (NDVH). MATERIALS AND METHODS:Ninety women with benign disease of uterus with failed medical management or not amenable to me...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-010-1778-5
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women wit...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-018-4884-4
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Meig's and Pseudo-Meig's syndromes have been reported in association with several malignancies but the concomitant existence of multiple synchronous benign and malignant tumors in association with Pseudo-Meigs' syndrome has not been reported in the published literature. CASE:A 55-year old African American w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-005-0052-8
更新日期：2006-02-01 00:00:00
abstract：AIM:To test the knowledge of women, attending a gynecology clinic, on HPV, cervix cancer awareness and the knowledge and willingness to use HPV vaccine for themselves or their children. SETTING:Routine gynecological and obstetrical care with ambulatory service in a medium-sized general hospital in a small town in Belg...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0487-1
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:To identify key genes related to the effect of estrogen on ovarian cancer. METHODS:Microarray data (GSE22600) were downloaded from Gene Expression Omnibus. Eight estrogen and seven placebo treatment samples were obtained using a 2 × 2 factorial designs, which contained 2 cell lines (PEO4 and 2008) and 2 treatm...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-015-3833-8
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:To assess adverse pregnancy outcomes in patients complicated with mild or severe Hyperemesis Gravidarum (HG). METHODS:A retrospective cohort study of women aged 18-45 with a singleton pregnancy that were admitted to the gynecological ward at the Soroka University Medical Center due to HG between the years 2013...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05192-y
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:To compare the techniques for cone measurement with ultrasound to determine the size of the resected tissue and to evaluate parameters which may be relevant for stratifying women at risk who need surveillance when pregnant. METHODS:The present study included women with a pathological cervical biopsy. Cervical ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05718-9
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate possible associations of genetic polymorphisms predisposing to cardiovascular disease with the development and/or the severity of preeclampsia. METHODS:A two hospital-based prospective case-control study was performed in Germany and Ghana. 470 blood samples of 250 Caucasia...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-2991-9
更新日期：2014-03-01 00:00:00
abstract：:In the 72 h after a single oral dose of 400 mg of the antiprogesterone mifepristone, 12 out of 14 first and one second trimester fetuses had a slight increase in heart rate; 2 fetuses died and one aborted. During the same 72 h, uterine activity increased moderately, and was physiological with no increase in resting pr...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF00931376
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:This analysis attempts to highlight the varied presentations, diagnostic difficulties, management and subsequent obstetric performances of women managed for advanced abdominal pregnancy. METHODS:A retrospective analysis of all 20 cases of abdominal pregnancies between 1976 and 2006, at the Mater Misericordiae ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-1260-4
更新日期：2011-01-01 00:00:00
abstract：:Uterine leiomyomas affect 20-30 % of women 35 years and older. Extrauterine leiomyomas are rare and present a greater diagnostic challenge. Those unusual growth patterns occur more often in women of reproductive age with a history of hysterectomy or surgery for uterine leiomyomas. They have been reported in the litera...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-014-3356-8
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:There is literature suggesting an intergenerational relationship between maternal and infant size for gestational age status and preterm birth, but much less is known about the contribution of paternal birth outcome to infant birth outcome. This study seeks to determine the association between paternal and infa...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05712-1
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:Human papillomavirus (HPV) can cause condylomata acuminata, also known as genital warts. Our aim was to evaluate the long-term recurrence of genital warts after primary carbon dioxide laser treatment before the introduction of the vaccination against HPV. METHODS:Recurrence rate and localization of genital war...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05242-5
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate perinatal outcome of seven pregnancies with twin reserve arterial perfusion sequence. MATERIALS AND METHODS:Study group included seven cases of acardiac twins. Out of seven acardiac twins, two cases were followed without interventions. We performed four alcohol ablation and one bipolar c...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0746-9
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare a low-dose aspirin treatment on placental and perinatal effects in the patients with poor obstetric history such as preeclampsia, intrauterine growth retardation (IUGR) in previous pregnancy. STUDY DESIGN:This retrospective study of 86 pregnant women was conducted between...
journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00404-006-0162-y
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Uterine carcinosarcomas are rare and highly aggressive tumours. Although surgery is the cornerstone of treatment, the extent of the procedure remains controversial. We sought to evaluate the available literature data regarding the rationale of lymphadenectomy and its possible impact on survival. METHODS:A s...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-010-1649-0
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:Laparoscopy has become the standard of care in the management of ovarian benign mucinous cystadenomas. One concern of the operative approach is the risk of recurrence. A previous study has found intraoperative cyst rupture and cystectomy to be the risk factors for recurrence. Our objective was to assess the inc...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3543-7
更新日期：2015-05-01 00:00:00
abstract：PURPOSE:The primary purpose of this study was to assess the influence of a systematic multidisciplinary birth preparation program on satisfaction with childbirth experience. A secondary aim was to detect factors that affect the childbirth satisfaction. METHODS:In this prospective study, 77 pregnant women who completed...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-017-4345-5
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:The objective of this study was to evaluate the levels of total microparticles (MPs) and microparticles-expressing tissue factor (TFMPs) in women with polycystic ovarian syndrome (PCOS) who use metformin comparing to those who do not take metformin. METHODS:We quantified total MPs and TFMPs in the plasma of 50...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-017-4471-0
更新日期：2017-10-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-018-4988-x
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:The aim of the study was to investigate the expression of Bridge-1 in human breast carcinomas, and to determine the in vitro regulation of Bridge-1 by activin A and the influence of Bridge-1 on activin A signaling in the human breast cancer cell line MCF-7. METHOD:Bridge-1 expression in human breast carcinomas...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1875-0
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:There is widespread consent that isolated locoregional recurrence (ILRR) in breast cancer should be treated surgically. On searching literature and guidelines most studies include ipsilateral recurrence in breast tissue or on thoracic wall post-mastectomy, recurrence in scar tissue as well as in ipsilateral axi...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05220-x
更新日期：2019-08-01 00:00:00
abstract：:We studied drug-induced cardiotoxic effects in 22 pregnant women having tocolysis with intravenous fenoterol and verapamil. Because CK-MB is released from the uterus and placenta, we used the determination of cardiac troponin T (cTnT) as it is one of the most sensitive and specific indicators of myocardial necrosis. C...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004040050239
更新日期：1999-01-01 00:00:00
abstract：:Three years' experience with gamete intrafallopian transfer (GIFT) are reported. Between June 1985 and July 1988, 173 clinical pregnancies were achieved in 357 patients over 488 cycles; 34 biochemical pregnancies achieved have not been included. There were 44 spontaneous abortions (25.4%) and 13 ectopic pregnancies (7...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02417603
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:To investigate the influence of different kinds of endometriotic lesions, especially peritoneal endometriotic implants in pain generation and the pain reduction after surgical excision in a prospective study. METHODS:Fifty-one pre-menopausal patients underwent surgical laparoscopy due to chronic pelvic pain, d...
journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00404-008-0921-z
更新日期：2009-09-01 00:00:00
abstract：:We have examined the predictive value of measurements of CASA (Cancer Associated Serum Antigen) levels in patients with breast carcinoma. The measurement uses monoclonal antibodies that bind to an epitope on the polymorphic epithelial mucin. CASA levels were of less value compared with the levels of other tumor marker...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004040050215
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:A previous decision analysis models for two strategic choices for trial of labor or repeated cesarean after prior cesarean concluded that the degree of wish for an additional future pregnancy appeared to be a major determinant for choice between the two strategic options. We had extended the analysis model to...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0373-x
更新日期：2007-11-01 00:00:00
abstract：:Association of pregnancy with esophageal cancer is an extremely rare event. The symptoms are frequently masked by factors related to normal pregnancy and diagnostic approaches are restricted by physical and psychological clinical events. Hence, the cancer stage is usually advanced at the time of diagnosis. The approac...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0724-2
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:Chemokines have been implicated in the pathological process of endometriosis. We compared the effects of peritoneal fluid obtained from patients with endometriosis (ePF) and controls without endometriosis (cPF) on the release of monocyte-specific CC chemokines such as monocyte chemotactic protein-1 (MCP-1), reg...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1583-1
更新日期：2011-06-01 00:00:00
