Abstract:
BACKGROUND:Uterine carcinosarcomas are rare and highly aggressive tumours. Although surgery is the cornerstone of treatment, the extent of the procedure remains controversial. We sought to evaluate the available literature data regarding the rationale of lymphadenectomy and its possible impact on survival. METHODS:A systematic Medline, PubMed and Scopus search with special focus on the publications of the last decade. RESULTS:Carcinosarcomas have similar clinical characteristics and behaviour with grade 3 endometrioid or aggressive variants of uterine adenocarcinoma. All studies have demonstrated that the FIGO stage of disease is the most important prognostic factor, followed by the depth of myometrial invasion, extra-uterine spread and positive peritoneal cytology. Moreover, lymph node involvement will be found in 14-38% of patients undergoing lymphadenectomy. This figure is similar to the one reported for endometrial carcinoma. Therefore, lymphadenectomy is mandatory for staging purposes. Regarding its impact on survival, the majority of studies confirm a significant survival benefit. The possible mechanisms for the improvement of survival from lymphadenectomy include removal of micro-metastatic foci, reduction of recurrence risk (removal of "target tissue") and mechanical circumvallate of the disease. Given that 5-38% of the patients will experience local recurrence and 30-83% distant metastases, lymphadenectomy reduces the risk of the first and identifies patients in advanced stage that may benefit from adjuvant chemotherapy, aiming to reduce the second and ultimately improve overall survival. CONCLUSIONS:Our review data fully justifies the rationale of lymphadenectomy, which beyond staging information seems to offer a measurable survival benefit.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Vorgias G,Fotiou Sdoi
10.1007/s00404-010-1649-0subject
Has Abstractpub_date
2010-12-01 00:00:00pages
659-64issue
6eissn
0932-0067issn
1432-0711journal_volume
282pub_type
杂志文章,评审abstract:OBJECTIVES:To evaluate the outcome of hysteroscopic myomectomy in patients with infertility and recurrent abortions. MATERIALS AND METHODS:This was a retrospective clinical analysis of 186 patients who underwent hysteroscopic myomectomy by monopolar electrode loop. A second-look diagnostic hysteroscopy was performed i...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1531-0
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:There is evidence of a probable key role of the activator protein-2 γ (AP-2γ) in placental development. It is still an open question whether AP-2γ expression may be influenced by preeclampsia, which is a serious pregnancy complication, or by smoking, which has deleterious effects on trophoblastic developme...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3473-4
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:There has been some discussion about the effect of antineoplastic agents on the trophoblast, and whether this is associated with abnormal placental function such as an increased risk of pre-eclampsia/eclampsia. We discuss a possible causal relationship between chemotherapy for breast cancer during pregnancy and...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-012-2257-y
更新日期:2012-07-01 00:00:00
abstract::Interleukin-6 (IL-6) is a pleiotropic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied the IL-6 secretion in vitro of 15 human cell lines derived from both squamous cell carcinoma (SCC) and adenocarcinoma of the uterine cervix. Four of the eight ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF01370929
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs). METHODS:The immunohistochemical analysis was performed using samples originating...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-012-2589-7
更新日期:2013-03-01 00:00:00
abstract::In spite of menstrual bleedings during premenopause FSH-concentration in blood increases significantly, however, without reaching post-menopausal amounts. Sometimes it is correlated with climacteric symptoms. FSH increases already 10 years before menopause, whereas LH does not change. Responsible for that is the parti...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/BF02417644
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To evaluate morphology of lateral ventricles of ventriculomegaly/hydrocephaly fetuses using 3D-sonography by virtual organ computer-aided analysis (VOCAL) technique and magnetic resonance imaging (MRI) and verify morphologic patterns related to etiology. METHODS:Seventeen fetuses presenting with ventricular en...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1666-z
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Osteogenesis imperfecta (OI) is a rare heritable heterogenous disorder characterized by bone fragility and susceptibility to fractures with a wide spectrum of clinical expression due to defects in collagen type I biosynthesis. The purpose of the review is to highlight the practical norms in pregnancies with ost...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-016-4012-2
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Primitive neuroectodermal tumors of uterus (PNET) are extremely rare in tumors of the female genital system and therefore there is no sufficient information about their diagnosis, treatment, and follow-up. CASE:The case is a 32-year-old, operated in emergency conditions due to intra-abdominal hemorrhage, an...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0699-z
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:Evaluation of lymph node (LN) metastases in endometrial carcinoma (EC) is an important prognostic factor and a required element of cancer staging. The purpose of this study is to analyze what factors might predict the likelihood of nodal involvement in EC. METHODS:A retrospective search of our institutional da...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3330-5
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Benign cystic teratomas are one of the most common benign ovarian neoplasms. Although its rupture is rare, once occurred it can cause complications such as granulomatous peritonitis, mimicking metastatic ovarian malignancy. CASE:A 39-year-old woman, Para 0-0-0-0, presented to the hospital with rapid abdomin...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-003-0479-8
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:To evaluate maternal-fetal outcomes in women of advanced maternal age (AMA; >35 years old) and women of physiological maternal age as controls (C; <35 years old). METHODS:Single-center, retrospective case-control analysis, from January 1 to December 31, 2013. For each group, we evaluated obstetric history, num...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3367-5
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Mastectomy without axillary dissection should be the standard treatment in patients with malignant form of cystosarcoma phyllodes. The role of postoperative radiotherapy and chemotherapy remains to be fully established. We evaluate treatment results in a group of patients with cystosarcoma phyllodes (CP) treate...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-003-0593-7
更新日期:2004-05-01 00:00:00
abstract::In erythrocytes, the extrusion of a cellular sodium level load is accomplished by the Ouabain--sensitive Na+/K+ pump and by the furosemide-sensitive Na+/K(+)--cotransport, which operates against the passive sodium permeability. An abnormal low rate of net sodium extrusion by the Na+/K+ cotransport was observed in pre-...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02766642
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To examine the clinicopathological characteristics of pregnant women who presented with intermittent hemorrhage occurring throughout pregnancy until delivery. METHOD:A total of 24 women with intermittent hemorrhage occurring throughout pregnancy were categorized into two groups, a group with persistent subch...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2972-z
更新日期:2014-02-01 00:00:00
abstract::In this study, our aim was to compare the effects of metformin and gonadotropin releasing hormone (GnRH) analogues in clinical and hormonal parameters in women with polycystic ovary syndrome (PCOS). There were 50 women with PCOS who were included in our study and they were divided into two groups. In this randomized t...
journal_title:Archives of gynecology and obstetrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00404-002-0344-1
更新日期:2003-06-01 00:00:00
abstract:PURPOSE:Type and volume of fluid administered for intrapartum maintenance had been reported to differently affect labor length, delivery mode, and cord artery pH and glucose level. We aimed to compare the effect of three different fluid regimens on labor duration. METHODS:In a randomized trial, healthy nulliparous in ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-017-4381-1
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To compare the subjective and objective cure rates, postoperative pain, postoperative complications, and postoperative quality of life of adjustable single-incision sling (Ajust®) versus tension-free vaginal tape-obturator (TVT-O™) in the treatment of female stress urinary incontinence (SUI). METHODS:Female pa...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-015-3949-x
更新日期:2016-02-01 00:00:00
abstract:STUDY OBJECTIVES:Endometrial ablation has been increasingly used over the last 30 years to manage patients with dysfunctional uterine bleeding. Of primary concern, however, is the potential of the procedure to mask the presence or delay the diagnosis of endometrial cancer. The aim of this study is to assess the long-te...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-015-3909-5
更新日期:2016-05-01 00:00:00
abstract:INTRODUCTION:Mild ovarian stimulation has been conceived, proposed and implemented in clinical practice as a safer and cheaper alternative to conventional strategies of controlled ovarian hyperstimulation in preparation for in vitro fertilization (IVF). Our aim was to summarize the key evidence on this topic and explor...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-012-2347-x
更新日期:2012-08-01 00:00:00
abstract:CASE REPORT:We report a case of an ectopic pregnancy in a caesarean section scar, which was initially misdiagnosed despite using ultrasound. For the first time, a strongly vascularised pelvic tumour developed while the titre of serum human chorionic gonadotrophin decreased after a curettage abortion for an unwanted pre...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-004-0683-1
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:We investigated the feasibility and acceptability of office hysteroscopic polypectomy using a new continuous-flow operative 16 Fr Gubbini's mini-resectoscope. This is a prospective clinical study (Canadian Task Force classification III). METHODS:The office hysteroscopic polypectomy was performed with a mini-re...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2754-7
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Angioleiomyoma is a rare benign solitary tumor, arising from the vascular smooth muscle. This tumor usually occurs in the subcutis of extremities, uncommonly in abdomen, often presents as a small (<2 cm) and is treated with excision. CASE:We report an extremely rare case of unusually large angioleiomyoma, f...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0663-y
更新日期:2009-02-01 00:00:00
abstract::A IVF twin pregnancy in a patient who had previously undergone a myomectomy ended in a intrauterine infection, placental abruption and fetal losses at 21 weeks. Intrauterine Candidiasis may have played a role in the pathogenesis of the unsuccessful outcome. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02505333
更新日期:1997-01-01 00:00:00
abstract::Two neighbouring centres, both located in an area where the prevalence of neural tube defects (NTDs) is low, were compared to determine if there was any advantage in their differing policies as regards the antenatal detection of NTDs. At both centres routine ultrasound examinations were performed at 16-18 weeks gestat...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF00931289
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:Cervical cancer, the second most common malignancy in women worldwide, is almost invariably associated with infection by human papillomavirus (HPV). However, although many women are infected with high-risk types of HPV, only a subset of infected women will ever develop cervical cancer. Therefore, host gene...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0504-4
更新日期:2008-06-01 00:00:00
abstract::Urodynamic and morphologic findings in 82 patients with stress urinary incontinence were analysed. All patients had undergone vaginal respectively abdominal hysterectomy with anterior colporrhaphy respectively urethrovesicopexy. Whereas in the abdominal group the urodynamic and morphologic findings improved significan...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02417572
更新日期:1989-01-01 00:00:00
abstract::Serum levels of CA 125 were determined in 239 patients suffering from gynecological malignancies. The upper limit for normal was 35 U/ml. Raised levels were found in 82% of patients with primary ovarian carcinoma, and in 29% of those with benign ovarian tumors. The values from patients with ovarian carcinomas in parti...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF00931312
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:We will present our experience in vulvar reconstruction using a local fascio-cutaneous flap, in order to get an easier intra-operative management and a good post-operative outcome. METHODS:Between May 2006 and December 2008, eight patients with vulvar carcinomas underwent a vulvar reconstruction, using a V-Y...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1603-1
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To investigate copeptin levels in women with GDM and women with uncomplicated pregnancies. METHODS:This case-control study was conducted on 45 women with GDM and 40 women with uncomplicated pregnancies. The maternal serum levels of copeptin were measured with enzyme-linked immunosorbent assay. RESULTS:Copepti...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2887-8
更新日期:2013-11-01 00:00:00